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01-09-2005 | Original Article

Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow

Authors: Haruhito Takano, Toshihiro Morita, Haruko Iida, Ken-ichi Asada, Masayoshi Kato, Kansei Uno, Ken Hirose, Akihiro Matsumoto, Katsu Takenaka, Yasunobu Hirata, Fumio Eto, Ryozo Nagai, Yoshiaki Sato, Toshiaki Nakajima

Published in: European Journal of Applied Physiology | Issue 1/2005

Abstract

We investigated the hemodynamic and hormonal responses to a short-term low-intensity resistance exercise (STLIRE) with the reduction of muscle blood flow. Eleven untrained men performed bilateral leg extension exercise under the reduction of muscle blood flow of the proximal end of both legs pressure-applied by a specially designed belt (a banding pressure of 1.3 times higher than resting systolic blood pressure, 160–180 mmHg), named as Kaatsu. The intensity of STLIRE was 20% of one repetition maximum. The subjects performed 30 repetitions, and after a 20-seconds rest, they performed three sets again until exhaustion. The superficial femoral arterial blood flow and hemodynamic parameters were measured by using the ultrasound and impedance cardiography. Serum concentrations of growth hormone (GH), vascular endothelial growth factor (VEGF), noradrenaline (NE), insulin-like growth factor (IGF)-1, ghrelin, and lactate were also measured. Under the conditions with Kaatsu, the arterial flow was reduced to about 30% of the control. STLIRE with Kaatsu significantly increased GH (0.11±0.03 to 8.6±1.1 ng/ml, P < 0.01), IGF-1 (210±40 to 236±56 ng/ml, P < 0.01), and VEGF (41±13 to 103±38 pg/ml, P < 0.05). The increase in GH was related to neither NE nor lactate, but the increase in VEGF was related to that in lactate (r = 0.57, P < 0.05). Ghrelin did not change during the exercise. The maximal heart rate (HR) and blood pressure (BP) in STLIRE with Kaatsu were higher than that without Kaatsu. Stroke volume (SV) was lower due to the decrease of the venous return by Kaatsu, but, total peripheral resistance (TPR) did not change significantly. These results suggest that STLIRE with Kaatsu significantly stimulates the exercise-induced GH, IGF, and VEGF responses with the reduction of cardiac preload during exercise, which may become a unique method for rehabilitation in patients with cardiovascular diseases.

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Title: Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow
Authors: Haruhito Takano
Toshihiro Morita
Haruko Iida
Ken-ichi Asada
Masayoshi Kato
Kansei Uno
Ken Hirose
Akihiro Matsumoto
Katsu Takenaka
Yasunobu Hirata
Fumio Eto
Ryozo Nagai
Yoshiaki Sato
Toshiaki Nakajima
Publication date: 01-09-2005
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 1/2005
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-005-1389-1

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Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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