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01-01-2012 | Original Article

The relationship between reaction time and response variability and somatosensory No-go potentials

Authors: Hiroki Nakata, Kiwako Sakamoto, Ryusuke Kakigi

Published in: European Journal of Applied Physiology | Issue 1/2012

Abstract

We investigated the relationship between reaction time (RT) and response variability and somatosensory Go/No-go potentials. Event-related potentials following electrical stimulation of the second (Go stimulus) or fifth (No-go stimulus) digit of the left hand were recorded from 16 subjects, and Go and No-go stimuli were presented at an even probability. The subjects were instructed to respond to the Go stimuli by pushing a button with their right thumb. We analyzed the correlation between RT and the N140 and P300 components, and between the standard deviation (SD) of RT and the N140 and P300. Neither the amplitude nor latency of the No-go-N140 (N140 evoked by No-go stimuli) or the Go-N140 (N140 evoked by Go stimuli) related significantly with RT and the SD of RT. There was a significant negative correlation between RT and the amplitude of the No-go-P300 (P300 evoked by No-go stimuli) at Fz and C3, indicating that subjects with a shorter RT had a No-go-P300 of larger amplitude. The latency of the Go-P300 (P300 evoked by Go stimuli) at Pz and C3 showed a significant correlation with RT. The SD of RT was significantly correlated with the amplitudes of the No-go-P300 at C3 and Go-P300 at Pz and C4, and the latency of the No-go-P300 at Cz and Go-P300 at Fz, Cz, Pz, C3, and C4. Our results suggest that response speed and variability for the Go stimulus in Go/No-go paradigms affect No-go-related neural activity for the No-go stimulus.

Band GP, Ridderinkhof KR, van der Molen MW (2003) Speed-accuracy modulation in case of conflict: the roles of activation and inhibition. Psychol Res 67:266–279PubMedCrossRef

Bellgrove MA, Hester R, Garavan H (2004) The functional neuroanatomical correlates of response variability: evidence from a response inhibition task. Neuropsychologia 42:1910–1916PubMedCrossRef

Bledowski C, Prvulovic D, Hoechstetter K, Scherg M, Wibral M, Goebel R, Linden DE (2004) Localizing P300 generators in visual target and distractor processing: a combined event-related potential and functional magnetic resonance imaging study. J Neurosci 24:9353–9360PubMedCrossRef

Bokura H, Yamaguchi S, Kobayashi S (2001) Electrophysiological correlates for response inhibition in a Go/NoGo task. Clin Neurophysiol 112:2224–2232PubMedCrossRef

Braver TS, Barch DM, Gray JR, Molfese DL, Snyder A (2001) Anterior cingulate cortex and response conflict: effects of frequency, inhibition and errors. Cereb Cortex 11:825–836PubMedCrossRef

Bruin KJ, Wijers AA (2002) Inhibition, response mode, and stimulus probability: a comparative event-related potential study. Clin Neurophysiol 113:1172–1182PubMedCrossRef

Donchin E, Coles MG (1988) Is the P300 component a manifestation of context updating? Behav Brain Sci 11:357–374CrossRef

Donkers FC, van Boxtel GJ (2004) The N2 in go/no-go tasks reflects conflict monitoring not response inhibition. Brain Cogn 56:165–176PubMedCrossRef

Doucet C, Stelmack MR (1999) The effect of response execution on P3 latency, reaction time, and movement time. Psychophysiology 36:351–363PubMedCrossRef

Falkenstein M, Koshlykova NA, Kiroi VN, Hoormann J, Hohnsbein J (1995) Late ERP components in visual and auditory Go/Nogo tasks. Electroencephalogr Clin Neurophysiol 96:36–43PubMedCrossRef

Falkenstein M, Hoormann J, Hohnsbein J (1999) ERP components in Go/Nogo tasks and their relation to inhibition. Acta Psychol 101:267–291CrossRef

Falkenstein M, Hoormann J, Hohnsbein J (2002) Inhibition-related ERP components: variation with modality, age, and time-on-task. J Psychophysiol 16:167–175CrossRef

Fallgatter AJ, Strik WK (1999) The NoGo-anteriorization as a neurophysiological standard-index for cognitive response control. Int J Psychophysiol 32:233–238PubMedCrossRef

Ford JM, Pfefferbaum A, Tinklenberg JR, Kopell BS (1982) Effects of perceptual and cognitive difficulty on P3 and RT in young and old adults. Electroencephalogr Clin Neurophysiol 54:311–321PubMedCrossRef

Garavan H, Ross TJ, Stein EA (1999) Right hemispheric dominance of inhibitory control: an event-related functional MRI study. Proc Natl Acad Sci USA 96:8301–8306PubMedCrossRef

Gemba H, Sasaki K (1989) Potential related to no-go reaction in go/no-nogo hand movement task with color discrimination in human. Neurosci Lett 101:263–268PubMedCrossRef

Gemba H, Sasaki K (1990) Potential related to no-go reaction in go/no-nogo hand movement with discrimination between tone stimuli of different frequencies in the monkey. Brain Res 537:340–344PubMedCrossRef

Jasper HH (1958) The ten-twenty electrode system of the International Federation. Electroencephalogr Clin Neurophysiol 10:371–375

Jodo E, Kayama Y (1992) Relation of a negative ERP component to response inhibition in a Go/No-go task. Electroencephalogr Clin Neurophysiol 82:477–482PubMedCrossRef

Johnson R Jr, Barnhardt J, Zhu J (2005) Differential effects of practice on the executive processes used for truthful and deceptive responses: an event-related brain potential study. Brain Res Cogn Brain Res 24:386–404PubMedCrossRef

Kamijo K, Nishihira Y, Hatta A, Kaneda T, Wasaka T, Kida T, Kuroiwa K (2004) Differential influences of exercise intensity on information processing in the central nervous system. Eur J Appl Physiol 92:305–311PubMedCrossRef

Kekoni J, Hämäläinen H, McCloud V, Reinikainen K, Näätänen R (1996) Is the somatosensory N250 related to deviance discrimination or conscious target detection? Electroencephalogr Clin Neurophysiol 100:115–125PubMedCrossRef

Kida T, Nishihira Y, Hatta A, Wasaka T (2003) Somatosensory N250 and P300 during discrimination tasks. Int J Psychophysiol 48:275–283PubMedCrossRef

Kida T, Nishihira Y, Wasaka T, Nakata H, Sakamoto M (2004) Differential modulation of temporal and frontal components of the somatosensory N140 and the effect of interstimulus interval in a selective attention task. Brain Res Cog Brain Res 19:33–39CrossRef

Kiefer M, Marzinzik F, Wetsbrod M, Scherg M, Spitzer M (1998) The time course of brain activations during response inhibition: evidence from event-related potentials in a go/no go task. NeuroReport 9:765–770PubMedCrossRef

Kok A (1986) Effects of degradation of visual stimulation on components of the event-related potential (ERP) in go/nogo reaction tasks. Biol Psychol 23:21–38PubMedCrossRef

Konishi S, Nakajima K, Uchida I, Kikyo H, Kameyama M, Miyashita Y (1999) Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI. Brain 122:981–991PubMedCrossRef

Kopp B, Mattler U, Goertz R, Rist F (1996) N2, P3 and the lateralized readiness potential in a nogo task involving selective response priming. Electroencephalogr Clin Neurophysiol 99:19–27PubMed

Kutas M, McCarthy G, Donchin E (1977) Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. Science 197:792–795PubMedCrossRef

McCarthy G, Donchin E (1981) A metric for thought: a comparison of P300 latency and reaction time. Science 211:77–80PubMedCrossRef

Nakamoto H, Mori S (2008) Effects of stimulus-response compatibility in mediating expert performance in baseball players. Brain Res 1189:179–188PubMedCrossRef

Nakata H, Inui K, Nishihira Y, Hatta A, Sakamoto M, Kida T, Wasaka T, Kakigi R (2004) Effects of a go/nogo task on event-related potentials following somatosensory stimulation. Clin Neurophysiol 115:361–368PubMedCrossRef

Nakata H, Inui K, Wasaka T, Tamura Y, Kida T, Kakigi R (2005a) Effects of ISI and stimulus probability on event-related go/nogo potentials after somatosensory stimulation. Exp Brain Res 162:293–299PubMedCrossRef

Nakata H, Inui K, Wasaka T, Akatsuka K, Kakigi R (2005b) Somato-motor inhibitory processing in humans: a study with MEG and ERP. Eur J Neurosci 22:1784–1792PubMedCrossRef

Nakata H, Inui K, Wasaka T, Tamura Y, Akatsuka K, Kida T, Kakigi R (2006a) Higher anticipated force required a stronger inhibitory process in go/nogo tasks. Clin Neurophysiol 117:1669–1676PubMedCrossRef

Nakata H, Inui K, Wasaka T, Tamura Y, Kida T, Kakigi R (2006b) The characteristics of the nogo-N140 component in somatosensory go/nogo tasks. Neurosci Lett 397:318–322PubMedCrossRef

Nakata H, Sakamoto K, Ferretti A, Gianni Perrucci M, Del Gratta C, Kakigi R, Luca Romani G (2008) Somato-motor inhibitory processing in humans: an event-related functional MRI study. NeuroImage 39:1858–1866PubMedCrossRef

Nakata H, Sakamoto K, Inui K, Hoshiyama M, Kakigi R (2009) The characteristics of no-go potentials with intraepidermal stimulation. NeuroReport 20:1149–1154PubMedCrossRef

Nakata H, Sakamoto K, Kakigi R (2010a) Effects of inter-stimulus interval on somatosensory Go/No-go ERPs. NeuroReport 21:1040–1044PubMedCrossRef

Nakata H, Sakamoto K, Kakigi R (2010b) Characteristics of No-go P300 component during somatosensory Go/No-go paradigms. Neurosci Lett 478:124–127PubMedCrossRef

Nieuwenhuis S, Yeung N, van den Wildenberg W, Ridderinkhof KR (2003) Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency. Cogn Affect Behav Neurosci 3:17–26PubMedCrossRef

Pfefferbaum A, Ford J, Johnson R Jr, Wenegrat B, Kopell BS (1983) Manipulation of P3 latency: speed vs. accuracy instructions. Electroencephalogr Clin Neurophysiol 55:188–197PubMedCrossRef

Pfefferbaum A, Ford JM, Weller BJ, Kopell BS (1985) ERPs to response production and inhibition. Electroencephalogr Clin Neurophysiol 60:423–434PubMedCrossRef

Ritter W, Simson R, Vaughan HG Jr, Friedman D (1979) A brain event related to the making of a sensory discrimination. Science 203:1358–1361PubMedCrossRef

Roche RA, Garavan H, Foxe JJ, O’mara SM (2005) Individual differences discriminate event-related potentials but not performance during response inhibition. Exp Brain Res 160:60–70PubMedCrossRef

Roth WT, Ford JM, Kopell BS (1978) Long-latency evoked potentials and reaction time. Psychophysiology 15:17–23PubMedCrossRef

Segalowitz SJ, Dywan J, Unsal A (1997) Attentional factors in response time variability after traumatic brain injury: an ERP study. J Int Neuropsychol Soc 3:95–107PubMed

Simmonds DJ, Fotedar SG, Suskauer SJ, Pekar JJ, Denckla MB, Mostofsky SH (2007) Functional brain correlates of response time variability in children. Neuropsychologia 45:2147–2157PubMedCrossRef

Smith JL, Johnstone SJ, Barry RJ (2006) Effects of pre-stimulus processing on subsequent events in a warned Go/NoGo paradigm: response preparation, execution and inhibition. Int J Psychophysiol 61:121–133PubMedCrossRef

Smith JL, Johnstone SJ, Barry RJ (2007) Response priming in the Go/NoGo task: the N2 reflects neither inhibition nor conflict. Clin Neurophysiol 118:343–355PubMedCrossRef

Strik WK, Fallgatter AJ, Brandeis D, Pascual-Marqui RD (1998) Three-dimensional tomography of event-related potentials during response inhibition: evidence for phasic frontal lobe activation. Electroencephalogr Clin Neurophysiol 108:406–413PubMedCrossRef

Tian Y, Yao D (2008) A study on the neural mechanism of inhibition of return by the event-related potential in the Go/NoGo task. Biol Psychol 79:171–178PubMedCrossRef

Vallesi A, Stuss DT, McIntosh AR, Picton TW (2009) Age-related differences in processing irrelevant information: evidence from event-related potentials. Neuropsychologia 47:577–586PubMedCrossRef

van Gaal S, Ridderinkhof KR, Fahrenfort JJ, Scholte HS, Lamme VA (2008) Frontal cortex mediates unconsciously triggered inhibitory control. J Neurosci 28:8053–8062PubMedCrossRef

Title: The relationship between reaction time and response variability and somatosensory No-go potentials
Authors: Hiroki Nakata
Kiwako Sakamoto
Ryusuke Kakigi
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 1/2012
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-011-1973-5

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The relationship between reaction time and response variability and somatosensory No-go potentials

Abstract

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