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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-02-2021 | Evoked Potential | Trauma

Isolated-check visual evoked potential: a more sensitive tool to detect traumatic optic neuropathy after orbital fracture

Authors: Yanjie Tian, Yinhao Wang, Ziyuan Liu, Xuemin Li

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2021

Abstract

Purpose

To establish a more sensitive diagnostic tool for traumatic optic neuropathy (TON), we explored the diagnostic efficacy of isolated-check visual evoked potential (ic-VEP) for TON in orbital fracture and compared ic-VEP with pattern-reversal visual evoked potential (P-VEP) testing.

Methods

This was a prospective single-center study. A total of 137 eyes from 131 patients diagnosed between December 2016 and October 2019 with orbital fractures were included in the study. Injury history, best-corrected visual acuity (BCVA), visual field, computed tomography (CT), P-VEP, and ic-VEP data were collected. Parameters of ic-VEP (signal-to-noise ratio [SNR]) and P-VEP (peak latency and amplitude of P100) were compared and diagnostic accuracy was analyzed.

Results

TON was associated with worse BCVA than non-TON (median 0.52 versus 0.10 logMAR, P < 0.001). SNRs were negatively associated with the P100 peak latency while positively associated with the P100 amplitude. The sensitivity of ic-VEP for TON (79.6%) was higher than that of P-VEP (61.2%, P = 0.049), although this difference was not statistically significant after Bonferroni correction. Using ic-VEP and P-VEP together could increase sensitivity (87.8%). Maximum areas under curve were obtained using the SNR criteria of 1.3, 1.47, and 1.54 at 8%, 16%, and 32% depth of modulation, respectively.

Conclusion

ic-VEP was more sensitive than P-VEP in diagnosing TON, and a combination of the two examination tests was recommended. The use of ic-VEP as the new diagnostic standard technique for TON should be considered.

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Title: Isolated-check visual evoked potential: a more sensitive tool to detect traumatic optic neuropathy after orbital fracture
Authors: Yanjie Tian
Yinhao Wang
Ziyuan Liu
Xuemin Li
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Evoked Potential
Evoked Potential
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2021
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04895-2

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Isolated-check visual evoked potential: a more sensitive tool to detect traumatic optic neuropathy after orbital fracture

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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