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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-09-2020 | Angiography | Retinal Disorders

Choroidal vascular densities of macular disease on ultra-widefield indocyanine green angiography

Authors: Anna Lee, Ho Ra, Jiwon Baek

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2020

Abstract

Purpose

We sought to compare choroidal vascular characteristics of central serous chorioretinopathy (CSC), polypoidal choroidal vasculopathy (PCV), and age-related macular degeneration (AMD) using quantitative analyses of ultra-widefield indocyanine green (UWF ICGA) images.

Methods

Eyes with CSC (n = 57), thick-choroid PCV (n = 29), thin-choroid PCV (n = 25), neovascular AMD (n = 45), and pachychoroid neovasculopathy (PNV) (n = 28) were enrolled. On UWF ICGA images, choroidal vascular density (CVD) was assessed using binarization in the total area, posterior pole, each quadrant, and vortex ampullae. Subfoveal choroidal thickness (SFCT) was measured using optical coherence tomography.

Results

The CVDs of thin-choroid PCV and typical AMD were lower than those of CSC (P = 0.002 and P < 0.001, respectively; P = 0.010 and P = 0.016 when adjusted for age.), whereas the CVDs of CSC, thick-choroid PCV, and PNV did not differ from each other (all P ≥ 0.161; all P ≥ 0.424 when adjusted for age). The CVD of the total area showed a positive correlation with SFCT in each also a whole group (all P ≤ 0.001). Meanwhile, the CVD of each ampullae positively correlated with that of the corresponding quadrant in total eyes and in each group (all P ≤ 0.001).

Conclusions

The mean CVD on UWF ICGA was increased in CSC, thick-choroid PCV, and PNV, whereas it was relatively low in thin-choroid PCV and typical AMD. Congestion at the vortex ampulla might be a cause of increased CVD, therefore increasing the SFCT in pachychoroid eyes.

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Title: Choroidal vascular densities of macular disease on ultra-widefield indocyanine green angiography
Authors: Anna Lee
Ho Ra
Jiwon Baek
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Keyword: Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04772-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Choroidal vascular densities of macular disease on ultra-widefield indocyanine green angiography

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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