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Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 9/2020

01-09-2020 | Glaucoma | Oculoplastics and Orbit

Relationship between the 24-h variability of blood pressure, ocular perfusion pressure, intraocular pressure, and visual field defect in thyroid associated orbitopathy

Authors: Yunhai Tu, Bangxun Mao, Jiagen Li, Weijie Liu, Mingna Xu, Qi Chen, Wencan Wu

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2020

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Abstract

Purpose

To evaluate the relationship between the 24-h variability of blood pressure (BP), ocular perfusion pressure (OPP), intraocular pressure (IOP), and visual field (VF) defect in thyroid-associated orbitopathy (TAO).

Methods

Thirty patients (60 eyes) with TAO were clinically examined in the Eye Hospital of Wenzhou Medical University. Patients were divided into two groups: one with VF defect (A) and the other without (B). Clinical parameters measured include 24-h IOP, 24-h blood pressure, orbital computed tomography (CT) scan, optical coherence tomography (OCT), and VFs. The pulse pressure (PP), mean arterial pressure (MAP), mean ocular perfusion pressure (MOPP), and 24-h fluctuations were calculated by formula.

Results

The MOPP and MAP fluctuation were greater in group A than B (p < 0.05) and had significant negative correlation to mean deviation (MD) of VF (R = − 0.434 P = 0.001*). There was no statistical difference in the muscle index, medial rectus muscle thickness, and blood pressure between two groups. Although there were no significant differences in the mean IOP and IOP fluctuation between two groups, the incidence of IOP abnormalities has higher trend in group A. Patients with 24-h IOP fluctuation ≥8 mmHg and the mean IOP > 21 mmHg in the group A were more than group B.

Conclusions

Dysthyroid optic neuropathy (DON) might have multiple pathogenic mechanisms. In this study, 24-h MOPP fluctuation and medial rectus maximal diameter were all the risk factors for DON. Higher mean IOP and 24-h IOP fluctuation might be risk factors for DON.
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Metadata
Title
Relationship between the 24-h variability of blood pressure, ocular perfusion pressure, intraocular pressure, and visual field defect in thyroid associated orbitopathy
Authors
Yunhai Tu
Bangxun Mao
Jiagen Li
Weijie Liu
Mingna Xu
Qi Chen
Wencan Wu
Publication date
01-09-2020
Publisher
Springer Berlin Heidelberg
Keyword
Glaucoma
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-020-04733-5

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