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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-03-2020 | Glaucoma | Glaucoma

Association between optic nerve head morphology in open-angle glaucoma and corneal biomechanical parameters measured with Corvis ST

Authors: Shuichiro Aoki, Yoshiaki Kiuchi, Kana Tokumo, Yuri Fujino, Masato Matsuura, Hiroshi Murata, Shunsuke Nakakura, Ryo Asaoka

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2020

Abstract

Purposes

To investigate associations between Corvis ST-measured corneal biomechanical parameters and glaucomatous optic nerve head (ONH) morphology.

Methods

In total, 118 eyes of 70 patients with open-angle glaucoma were examined in this retrospective cross-sectional study. We measured Heidelberg retina tomograph and Corvis ST values in all eyes. We used the linear mixed model in four sectors (temporal superior, TS; temporal inferior, TI; nasal superior, NS; and nasal inferior, NI) to detect associations between six ONH-related parameters and 14 Corvis ST–related parameters, controlling for age, intraocular pressure, axial length, and central corneal thickness. We calculated the ONH temporal and nasal sector vertical asymmetries (TS-TI and NS-NI asymmetries) and identified the optimal linear mixed models to describe them using model selection with the second-order bias corrected Akaike Information Criterion.

Results

The Corvis ST A2 velocity was negatively associated with the rim volume in the NS sector (p < 0.05). The optimal model for TS-TI asymmetry was TS-TI asymmetry = − 3.22 + 0.15 × HC time + 0.88 × HC deflection amplitude, whereas that for NS-NI asymmetry was 0.49–0.048 × axial length − 2.45 × A2 velocity.

Conclusion

Glaucomatous ONH superior-inferior asymmetries were associated with biomechanical properties measured with Corvis ST. Eyes with superior-dominant rim volume reduction of ONH were associated with small deformations and slow recovery of the cornea.

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Title: Association between optic nerve head morphology in open-angle glaucoma and corneal biomechanical parameters measured with Corvis ST
Authors: Shuichiro Aoki
Yoshiaki Kiuchi
Kana Tokumo
Yuri Fujino
Masato Matsuura
Hiroshi Murata
Shunsuke Nakakura
Ryo Asaoka
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keyword: Glaucoma
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04572-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Association between optic nerve head morphology in open-angle glaucoma and corneal biomechanical parameters measured with Corvis ST

Abstract

Purposes

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purposes

Methods

Results

Conclusion

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