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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2018 | Oncology

Features of choroidal naevi on swept source optical coherence tomography angiography and structural reverse flow optical coherence tomography

Authors: Zaria C. Ali, Jane Gray, Konstantinos Balaskas

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2018

Abstract

Purpose

The purpose of our study was to describe features of choroidal naevi as seen on swept source optical coherence tomography angiography (OCTA) and also on en face images derived from structural data from OCTA.

Methods

A prospective observational cohort study was carried out. Patients attending a specialised choroidal naevomelanocytic with known naevi were imaged with swept source OCTA.

Results

Seventy-one eyes of 70 patients were imaged. Forty-three patients and 44 eyes were included. Mean age was 57.7 years (SD 14.9), range 29–81 years. Male to female ratio was 20:23. On OCTA after manual segmentation, naevi could be seen in 47.6% of cases, whereas in the en face images, naevi could be clearly visualised in 79.5% of cases. In OCTA, the superficial and deep capillary plexuses appeared undisturbed as did the outer retinal layer appeared in all cases of flat naevi. In choroidal naevi with mild elevation, the outer retinal layer appeared more susceptible to projection artefacts from overlying retinal vasculature. The choriocapillaris layer showed a fading of the normal homogenous vascular mosaic corresponding to the area of the naevus. In the en face images, even the faintest and thinnest naevi could be visualised in striking detail, and naevi greater than 120 μm thickness appeared darker (p = 0.0034).

Conclusions

OCTA presents characteristic changes in the choriocapillaris layers in cases of choroidal naevi. The association of naevus substance appearing darker with increasing thickness may offer a novel prognostic clue. En face structural OCT may allow accurate, detailed measurement of lateral dimensions which could be of value in the monitoring of suspicious naevi.

Moult E, Choi W, Waheed NK, Adhi M, Lee B, Lu CD, Jayaraman V, Potsaid B, Rosenfeld PJ, Duker JS, Fujimoto JG (2014) Ultrahigh-speed swept-source OCT angiography in exudative AMD. Ophthalmic Surg Lasers Imaging Retina 45(6):496–505. https://doi.org/10.3928/23258160-20141118-03 CrossRefPubMedPubMedCentral

Moult EM, Waheed NK, Novais EA, Choi W, Lee B, Ploner SB, Cole ED, Louzada RN, Lu CD, Rosenfeld PJ, Duker JS, Fujimoto JG (2016) Swept-source optical coherence tomography angiography reveals choriocapillaris alterations in eyes with nascent geographic atrophy and drusen-associated geographic atrophy. Retina 36:S2–S11. https://doi.org/10.1097/iae.0000000000001287 CrossRefPubMedPubMedCentral

Yu S, Lu J, Cao D, Liu R, Liu B, Li T, Luo Y, Lu L (2016) The role of optical coherence tomography angiography in fundus vascular abnormalities. BMC Ophthalmol 16. https://doi.org/10.1186/s12886-016-0277-2

Pierro L, Battaglia Parodi M, Rabiolo A, Introini U, Querques G, Bandello F (2016) Optical coherence tomography angiography of miscellaneous retinal disease. Dev Ophthalmol 56:174–180. https://doi.org/10.1159/000442810 CrossRefPubMed

Feucht N, Maier M, Lohmann CP, Reznicek L (2016) OCT angiography findings in acute central serous chorioretinopathy. Ophthalmic Surg Lasers Imaging Retina 47(4):322–327. https://doi.org/10.3928/23258160-20160324-03 CrossRefPubMed

Gong J, Yu S, Gong Y, Wang F, Sun X (2016) The diagnostic accuracy of optical coherence tomography angiography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography. J Ophthalmol 2016:7521478. https://doi.org/10.1155/2016/7521478 CrossRefPubMedPubMedCentral

Valverde-Megias A, Say EA, Ferenczy SR, Shields CL (2017) Differential macular features on optical coherence tomography angiography in eyes with choroidal nevus and melanoma. Retina 37(4):731–740. https://doi.org/10.1097/iae.0000000000001233 CrossRefPubMed

Cennamo G, Romano MR, Breve MA, Velotti N, Reibaldi M, de Crecchio G, Cennamo G (2017) Evaluation of choroidal tumors with optical coherence tomography: enhanced depth imaging and OCT-angiography features. Eye (Lond). https://doi.org/10.1038/eye.2017.14

Glittenberg C(2017) Extracting and segmenting 3D choroidal vasculography information from swept source OCT A data In: Association for research and vision in Ophthalmology, Imaging in the eye Conference, Baltimore, 2017

10.

Michalewska Z, Michalewski J, Nawrocki J (2016) Swept source optical coherence tomography of choroidal nevi. Can J Ophthalmol 51(4):271–276. https://doi.org/10.1016/j.jcjo.2016.02.009 CrossRefPubMed

11.

Sumich P, Mitchell P, Wang J (1998) Choroidal nevi in a white population: the blue mountains eye study. Arch Ophthalmol 116(5):645–650. https://doi.org/10.1001/archopht.116.5.645 CrossRefPubMed

12.

Singh AD, Kalyani P, Topham A (2005) Estimating the risk of malignant transformation of a choroidal nevus. Ophthalmology 112(10):1784–1789. https://doi.org/10.1016/j.ophtha.2005.06.011 CrossRefPubMed

13.

Shields CL, Furuta M, Berman EL, Zahler JD, Hoberman DM, Dinh DH, Mashayekhi A, Shields JA (2009) Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases. Arch Ophthalmol 127(8):981–987. https://doi.org/10.1001/archophthalmol.2009.151 CrossRefPubMed

14.

Say EA, Ferenczy S, Magrath GN, Samara WA, Khoo CT, Shields CL (2016) Image quality and artifacts on optical coherence tomography angiography: comparison of pathologic and paired fellow eyes in 65 patients with unilateral choroidal melanoma treated with plaque radiotherapy. Retina. https://doi.org/10.1097/iae.0000000000001414

Title: Features of choroidal naevi on swept source optical coherence tomography angiography and structural reverse flow optical coherence tomography
Authors: Zaria C. Ali
Jane Gray
Konstantinos Balaskas
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-3924-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Features of choroidal naevi on swept source optical coherence tomography angiography and structural reverse flow optical coherence tomography

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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