Corneal endothelial loss after crosslinking with riboflavin and ultraviolet-A

Excerpt

Keratoconus is a progressive, non-inflammatory degenerative ectasia of the cornea characterized by paraxial stromal thinning, irregular astigmatism and progressive loss of visual acuity. Current treatment options focus on the correction of the associated refractive error by means of glasses for mild keratoconus, or rigid contact lenses for moderate keratoconus. As the corneal ectasia progresses, contact lenses can no longer be fitted, and 20 % of patients require corneal transplantation [1]. Corneal collagen crosslinking by a combined topical riboflavin and UVA treatment has been proposed to stabilize and prevent progression of corneal ectasia in keratoconus [2]. This technique is still undergoing both clinical evaluation and risk assessment worldwide. In this case report, we present a patient with irreversible corneal endothelial damage and significant visual deterioration following corneal crosslinking. …