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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-11-2012 | Retinal Disorders

Effect of preoperative retinal sensitivity and fixation on long-term prognosis for idiopathic macular holes

Authors: Zhongcui Sun, Dekang Gan, Chunhui Jiang, Min Wang, Alicia Sprecher, Alice C. Jiang, Gezhi Xu

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2012

Abstract

Background

To study the roles of preoperative retinal sensitivity and fixation exams in predicting the long-term prognosis of idiopathic macular hole (IMH) patients after successful vitrectomy.

Methods

A total of 39 IMH patients (39 eyes) were included in this prospective cohort case series study. Twenty-three gauge pars plana vitrectomy was performed on each patient. Results of best-corrected visual acuity (BCVA), macular hole diameter, MP − 1 microperimetry (MP − 1) tests, and continuity of the photoreceptor inner and outer segment (IS/OS) junction were recorded for analysis.

Results

Postoperative BCVA at 12 months was significantly correlated with macular hole diameters (p < 0.05), preoperative BCVA (p = 0.020), mean retinal sensitivity (p < 0.001), and fixation location percentage (p < 0.001). However, merely preoperative mean retinal sensitivity (r = 0.5448, p < 0.001) and fixation location percentage (r = 0.5624, p < 0.001) were suggested to be quantitatively predictive for the visual prognosis by multiple stepwise linear regression analysis. Moreover, patients that had smaller hole sizes (p < 0.01), better mean retinal sensitivity (p = 0.003), higher fixation quality scores, and higher fixation location percentage (p = 0.008) before surgery were prone to get continuous IS/OS junction 12 months after surgery.

Conclusions

MP-1 exams evaluate the dysfunctional hole margin and thus provide more comprehensive information of the preoperative visual function of IMH patients. Both mean retinal sensitivity and fixation behaviors are ideal measurements in predicting the prognosis after successful macular hole surgery.

McDonnell PJ, Fine SL, Hillis AI (1982) Clinical features of idiopathic macular cysts and holes. Am J Ophthalmol 93:777–786PubMed

Gass JD (1988) Idiopathic senile macular hole. Its early stages and pathogenesis. Arch Ophthalmol 106:629–639PubMedCrossRef

Wittich W, Overbury O, Kapusta MA, Faubert J (2005) Visual function assessment and metamorphopsia after macular hole surgery. Ophthalmic Physiol Opt 25:534–542PubMedCrossRef

Grigoropoulos VG, Theodossiadis GP, Theodossiadis PG Association of the preoperative photoreceptor layer defect as assessed by optical coherence tomography with the functional outcome after macular hole closure: a long follow-up study. Ophthalmologica 225:47–54

Kelly NE, Wendel RT (1991) Vitreous surgery for idiopathic macular holes. Results of a pilot study. Arch Ophthalmol 109:654–659PubMedCrossRef

Passemard M, Yakoubi Y, Muselier A, Hubert I, Guillaubey A, Bron AM, Berrod JP, Creuzot-Garcher C Long-term outcome of idiopathic macular hole surgery. Am J Ophthalmol 149:120–126

Haritoglou C, Gass CA, Schaumberger M, Ehrt O, Gandorfer A, Kampik A (2001) Macular changes after peeling of the internal limiting membrane in macular hole surgery. Am J Ophthalmol 132:363–368PubMedCrossRef

Tranos PG, Ghazi-Nouri SM, Rubin GS, Adams ZC, Charteris DG (2004) Visual function and subjective perception of visual ability after macular hole surgery. Am J Ophthalmol 138:995–1002PubMedCrossRef

Ullrich S, Haritoglou C, Gass C, Schaumberger M, Ulbig MW, Kampik A (2002) Macular hole size as a prognostic factor in macular hole surgery. Br J Ophthalmol 86:390–393PubMedCrossRef

10.

Miura G, Mizunoya S, Arai M, Hayashi M, Yamamoto S (2007) Early postoperative macular morphology and functional outcomes after successful macular hole surgery. Retina 27:165–168PubMedCrossRef

11.

Uemoto R, Yamamoto S, Aoki T, Tsukahara I, Yamamoto T, Takeuchi S (2002) Macular configuration determined by optical coherence tomography after idiopathic macular hole surgery with or without internal limiting membrane peeling. Br J Ophthalmol 86:1240–1242PubMedCrossRef

12.

Ryan EH Jr, Gilbert HD (1994) Results of surgical treatment of recent-onset full-thickness idiopathic macular holes. Arch Ophthalmol 112:1545–1553PubMedCrossRef

13.

Tognetto D, Grandin R, Sanguinetti G, Minutola D, Di Nicola M, Di Mascio R, Ravalico G (2006) Internal limiting membrane removal during macular hole surgery: results of a multicenter retrospective study. Ophthalmology 113:1401–1410PubMedCrossRef

14.

Willis AW, Garcia-Cosio JF (1996) Macular hole surgery. Comparison of longstanding versus recent macular holes. Ophthalmology 103:1811–1814PubMed

15.

Freeman WR, Azen SP, Kim JW, El-Haig W, Mishell DR 3rd, Bailey I (1997) Vitrectomy for the treatment of full-thickness stage 3 or 4 macular holes. Results of a multicentered randomized clinical trial. The Vitrectomy for Treatment of Macular Hole Study Group. Arch Ophthalmol 115:11–21PubMedCrossRef

16.

Roth DB, Smiddy WE, Feuer W (1997) Vitreous surgery for chronic macular holes. Ophthalmology 104:2047–2052PubMed

17.

Bainbridge J, Herbert E, Gregor Z (2008) Macular holes: vitreoretinal relationships and surgical approaches. Eye (Lond) 22:1301–1309CrossRef

18.

Richter-Mueksch S, Vecsei-Marlovits PV, Sacu SG, Kiss CG, Weingessel B, Schmidt-Erfurth U (2007) Functional macular mapping in patients with vitreomacular pathologic features before and after surgery. Am J Ophthalmol 144:23–31PubMedCrossRef

19.

Vujosevic S, Midena E, Pilotto E, Radin PP, Chiesa L, Cavarzeran F (2006) Diabetic macular edema: correlation between microperimetry and optical coherence tomography findings. Invest Ophthalmol Vis Sci 47:3044–3051PubMedCrossRef

20.

Weingessel B, Sacu S, Vecsei-Marlovits PV, Weingessel A, Richter-Mueksch S, Schmidt-Erfurth U (2009) Interexaminer and intraexaminer reliability of the microperimeter MP-1. Eye (Lond) 23:1052–1058CrossRef

21.

Zou H, Zhang X, Xu X, Yu S (2006) Quantitative in vivo retinal thickness measurement in Chinese healthy subjects with retinal thickness analyzer. Invest Ophthalmol Vis Sci 47:341–347PubMedCrossRef

22.

Ozdemir H, Karacorlu M, Senturk F, Karacorlu SA, Uysal O (2010) Retinal sensitivity and fixation changes 1 year after triamcinolone acetonide assisted internal limiting membrane peeling for macular hole surgery—a MP-1 microperimetric study. Acta Ophthalmol 88:e222–227

23.

Tarita-Nistor L, Gonzalez EG, Mandelcorn MS, Lillakas L, Steinbach MJ (2009) Fixation stability, fixation location, and visual acuity after successful macular hole surgery. Invest Ophthalmol Vis Sci 50:84–89PubMedCrossRef

24.

Sano M, Shimoda Y, Hashimoto H, Kishi S (2009) Restored photoreceptor outer segment and visual recovery after macular hole closure. Am J Ophthalmol 147(313–318):e311

25.

Fujii GY, de Juan E Jr, Sunness J, Humayun MS, Pieramici DJ, Chang TS (2002) Patient selection for macular translocation surgery using the scanning laser ophthalmoscope. Ophthalmology 109:1737–1744PubMedCrossRef

26.

Gass JD (1995) Reappraisal of biomicroscopic classification of stages of development of a macular hole. Am J Ophthalmol 119:752–759PubMed

27.

Gass JD (1999) Müller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis. Arch Ophthalmol 117:821–823PubMedCrossRef

28.

Tanner V, Williamson TH (2000) Watzke-Allen slit beam test in macular holes confirmed by optical coherence tomography. Arch Ophthalmol 118:1059–1063PubMed

29.

Nakabayashi M, Fujikado T, Ohji M, Saito Y, Tano Y (2000) Fixation patterns of idiopathic macular holes after vitreous surgery. Retina 20:170–175PubMedCrossRef

30.

White JM, Bedell HE (1990) The oculomotor reference in humans with bilateral macular disease. Invest Ophthalmol Vis Sci 31:1149–1161PubMed

31.

Fletcher DC, Schuchard RA (1997) Preferred retinal loci relationship to macular scotomas in a low-vision population. Ophthalmology 104:632–638PubMed

32.

Ko TH, Witkin AJ, Fujimoto JG, Chan A, Rogers AH, Baumal CR, Schuman JS, Drexler W, Reichel E, Duker JS (2006) Ultrahigh-resolution optical coherence tomography of surgically closed macular holes. Arch Ophthalmol 124:827–836PubMedCrossRef

33.

Frangieh GT, Green WR, Engel HM (1981) A histopathologic study of macular cysts and holes. Retina 1:311–336PubMedCrossRef

Title: Effect of preoperative retinal sensitivity and fixation on long-term prognosis for idiopathic macular holes
Authors: Zhongcui Sun
Dekang Gan
Chunhui Jiang
Min Wang
Alicia Sprecher
Alice C. Jiang
Gezhi Xu
Publication date: 01-11-2012
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2012
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-012-1997-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of preoperative retinal sensitivity and fixation on long-term prognosis for idiopathic macular holes

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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