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Open Access 01-12-2021 | Portal Vein Thrombosis | Letter to the Editors

Immediate high-dose intravenous immunoglobulins followed by direct thrombin-inhibitor treatment is crucial for survival in Sars-Covid-19-adenoviral vector vaccine-induced immune thrombotic thrombocytopenia VITT with cerebral sinus venous and portal vein thrombosis

Authors: Tilmann Graf, Thomas Thiele, Randolf Klingebiel, Andreas Greinacher, Wolf-Rüdiger Schäbitz, Isabell Greeve

Excerpt

Dear Sirs, …

Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S (2021) Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med. https://doi.org/10.1056/NEJMoa2104840 (Epub 2021 Apr 9 PMID: 33835769)CrossRefPubMedPubMedCentral

Schultz NH, Sørvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, Wiedmann M, Aamodt AH, Skattør TH, Tjønnfjord GE, Holme PA (2021) Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination. N Engl J Med. https://doi.org/10.1056/NEJMoa2104882 (Epub 2021 Apr 9 PMID: 33835768)CrossRefPubMedPubMedCentral

Greinacher A, Selleng K, Warkentin TE (2017) Autoimmune heparin-induced thrombocytopenia. J Thromb Haemost 15(11):2099–2114. https://doi.org/10.1111/jth.13813 (Epub 2017 Sep 28 PMID: 28846826)CrossRefPubMed

Warkentin TE (2019) High-dose intravenous immunoglobulin for the treatment and prevention of heparin-induced thrombocytopenia: a review. Expert Rev Hematol 12(8):685–698. https://doi.org/10.1080/17474086.2019.1636645 (Epub 2019 Jul 5 PMID: 31274032)CrossRefPubMed

Gray A, Wallis DE, Hursting MJ, Katz E, Lewis BE (2007) Argatroban therapy for heparin-induced thrombocytopenia in acutely ill patients. Clin Appl Thromb Hemost 13(4):353–361. https://doi.org/10.1177/1076029607303617 (PMID: 17911186)CrossRefPubMed

Title: Immediate high-dose intravenous immunoglobulins followed by direct thrombin-inhibitor treatment is crucial for survival in Sars-Covid-19-adenoviral vector vaccine-induced immune thrombotic thrombocytopenia VITT with cerebral sinus venous and portal vein thrombosis
Authors: Tilmann Graf
Thomas Thiele
Randolf Klingebiel
Andreas Greinacher
Wolf-Rüdiger Schäbitz
Isabell Greeve
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Portal Vein Thrombosis
Thrombocytopenia
Portal Vein Thrombosis
Thrombosis
Heparin
Published in: Journal of Neurology / Issue 12/2021
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-021-10599-2