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Journal of Neurology

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01-07-2020 | Artificial Intelligence | Original Communication

Spatial metabolic profiles to discriminate dementia with Lewy bodies from Alzheimer disease

Authors: Tomomichi Iizuka, Masashi Kameyama

Published in: Journal of Neurology | Issue 7/2020

Abstract

Background

To differentiate dementia with Lewy bodies (DLB) from Alzheimer disease (AD) using a single imaging modality is challenging, because of their common hypometabolic findings. Scaled subprofile modeling/principal component analysis (SSM/PCA), an unsupervised artificial intelligence, has the potential to offer an alternative to image analysis.

Objective

We aimed to produce spatial metabolic profiles to discriminate DLB from AD and to identify the characteristics of the profiles.

Methods

Fifty individuals each with DLB, AD, and normal cognition (NL) underwent ¹⁸F-FDG-PET and MRI. The spatial metabolic profile to differentiate DLB from AD (DLB-AD discrimination profile) was determined using SSM/PCA with tenfold cross validation. For comparison, we also produced disease-related profiles that can discriminate AD and DLB from NL (AD- and DLB-related profiles, respectively).

Results

The DLB-AD discrimination profile significantly differentiated DLB from AD with comparable accuracy to that of discriminating DLB and AD from NL. The AD- and DLB-related profiles comprised metabolic imaging features typical of each pathology. In contrast, the DLB-AD discrimination profile emphasized preservation in the posterior cingulate cortex (cingulate island sign) and medial temporal lobe, and occipital hypometabolism. Common hypometabolic findings between DLB and AD were less noticeable in the profile. The DLB-related profile significantly correlated with cognitive function and three core features of DLB, whereas the DLB-AD discrimination profile did not.

Conclusions

Spatial metabolic profile that could discriminate DLB from AD emphasized different imaging features and eliminated common findings between DLB and AD. Neither cognitive function nor core features were associated with the profile.

Mosconi L (2005) Brain glucose metabolism in the early and specific diagnosis of Alzheimer’s disease. FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging 32(4):486–510CrossRef

Ishii K, Soma T, Kono AK, Sofue K, Miyamoto N, Yoshikawa T et al (2007) Comparison of regional brain volume and glucose metabolism between patients with mild dementia with Lewy bodies and those with mild Alzheimer’s disease. J Nucl Med 48:704–711CrossRef

Ishii K, Imamura T, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H et al (1998) Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer’s disease. Neurology 51:125–130CrossRef

Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhl DE (2001) Alzheimer’s disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol 50:358–365CrossRef

Albin RL, Minoshima S, D’Amato CJ, Frey KA, Kuhl DA, Sima AA (1996) Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology 47:462–466CrossRef

Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE (1997) Metabolic reduction in the posterior cingulate cortex in very early Alzheimer’s disease. Ann Neurol 42:85–94CrossRef

Lim SM, Katsifis A, Villemagne VL, Best R, Jones G, Saling M et al (2009) The 18F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. J Nucl Med 50:1638–1645CrossRef

Imabayashi E, Yokoyama K, Tsukamoto T, Sone D, Sumida K, Kimura Y et al (2016) The cingulate island sign within early Alzheimer’s disease-specific hypoperfusion volumes of interest is useful for differentiating Alzheimer’s disease from dementia with Lewy bodies. EJNMMI Res 6:67CrossRef

Iizuka T, Fukasawa M, Kameyama M (2019) Deep learning-based imaging classification identified cingulate island sign in dementia with Lewy bodies. Sci Rep 9(1):8944CrossRef

10.

Moeller JR, Strother SC (1991) A regional covariance approach to the analysis of functional patterns in positron emission tomographic data. J Cereb Blood Flow Metab 11:A121–A135CrossRef

11.

Alexander GE, Moeller JR (1994) Application of the scaled subprofile model to functional imaging in neuropsychiatric disorders: a principal component approach to modeling brain function in disease. Hum Brain Mapp 2(1):79–94CrossRef

12.

Eidelberg D (2009) Metabolic brain networks in neurodegenerative disorders: a functional imaging approach. Trends Neurosci 32:548–557CrossRef

13.

Niethammer M, Eidelberg D (2012) Metabolic brain networks in translational neurology: concepts and applications. Ann Neurol 72:635–647CrossRef

14.

Habeck C, Foster NL, Perneczky R, Kurz A, Alexopoulos P, Koeppe RA et al (2008) Multivariate and univariate neuroimaging biomarkers of Alzheimer’s disease. Neuroimage 40:1503–1515CrossRef

15.

Matsuda H, Mizumura S, Nemoto K, Yamashita F, Imabayashi E, Sato N et al (2012) Automatic voxel-based morphometry of structural MRI by SPM8 plus diffeomorphic anatomic registration through exponentiated lie algebra improves the diagnosis of probable Alzheimer disease. Am J Neuroradiol 33:1109–1114CrossRef

16.

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D et al (2017) Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium. Neurology 89:88–100CrossRef

17.

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:263–269CrossRef

18.

Iizuka T, Kameyama M (2016) Cingulate island sign on FDG-PET is associated with medial temporal lobe atrophy in dementia with Lewy bodies. Ann Nucl Med 30:421–429CrossRef

19.

Varrone A, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Booij J et al (2013) European multicentre database of healthy controls for [123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur J Nucl Med Mol Imaging 40:213–227CrossRef

20.

Tossici-Bolt L, Hoffmann SM, Kemp PM, Mehta RL, Fleming JS (2006) Quantification of [123I] FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio. Eur J Nucl Med Mol Imaging 33:1491–1499CrossRef

21.

Kantarci K, Lowe VJ, Boeve BF, Weigand SD, Senjem ML, Przybelski SA et al (2012) Multimodality imaging characteristics of dementia with Lewy bodies. Neurobiol Aging 33:2091–2105CrossRef

22.

O'Brien JT, Firbank MJ, Davison C et al (2014) 18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias. J Nucl Med 55(12):1959–1965CrossRef

23.

Shimizu S, Hirao K, Kanetaka H, Namioka N, Hatanaka H, Hirose D et al (2016) Utility of the combination of DAT SPECT and MIBG myocardial scintigraphy in differentiating dementia with Lewy bodies from Alzheimer’s disease. Eur J Nucl Med Mol Imaging 43(1):184–192CrossRef

24.

Ma Y, Tang C, Spetsieris PG, Dhawan V, Eidelberg D (2007) Abnormal metabolic network activity in Parkinson’s disease: test-retest reproducibility. J Cereb Blood Flow Metab 27:597–605CrossRef

25.

Mure H, Hirano S, Tang CC, Isaias IU, Antonini A, Ma Y et al (2011) Parkinson’s disease tremor-related metabolic network: characterization, progression, and treatment effects. Neuroimage 54(2):1244–1253CrossRef

26.

Huang C, Mattis P, Tang C, Perrine K, Carbon M, Eidelberg D (2007) Metabolic brain networks associated with cognitive function in Parkinson’s disease. Neuroimage 34:714–723CrossRef

27.

Kantarci K, Ferman TJ, Boeve BF, Weigand SD, Przybelski S, Vemuri P et al (2012) Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies. Neurology 79:553–560CrossRef

28.

Murray ME, Ferman TJ, Boeve BF, Przybelski SA, Lesnick TG, Liesinger AM et al (2013) MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. Neurology 81:1681–1689CrossRef

29.

Graff-Radford J, Murray ME, Lowe VJ, Boeve BF, Ferman TJ, Przybelski SA et al (2014) Dementia with Lewy bodies: basis of cingulate island sign. Neurology 83:801–809CrossRef

30.

Iizuka T, Iizuka R, Kameyama M (2017) Cingulate island sign temporally changes in dementia with Lewy bodies. Sci Rep 7:14745CrossRef

Title: Spatial metabolic profiles to discriminate dementia with Lewy bodies from Alzheimer disease
Authors: Tomomichi Iizuka
Masashi Kameyama
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Keywords: Artificial Intelligence
Dementia
Dementia
Published in: Journal of Neurology / Issue 7/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-09790-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Spatial metabolic profiles to discriminate dementia with Lewy bodies from Alzheimer disease

Abstract

Background

Objective

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusions

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