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Journal of Neurology
Published in: Journal of Neurology 6/2019

01-06-2019 | Seminoma | Original Communication

Granulomatous CNS inflammation associated with seminoma

Authors: Jennifer Massey, Susan Walker, Malcolm Galloway, Suran Fernando, John Parratt, Ann-Marie Quigley, Desmond P. Kidd

Published in: Journal of Neurology | Issue 6/2019

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Abstract

Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment.
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Fritz D, van de Beek D, Brouwer MC (2016) Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis. BMC Neurol 16(1):220CrossRefPubMedPubMedCentral
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Paparel P, Devonec M, Perrin P, Ruffion A, Decaussin-Petrucci M, Akin O et al (2007) Association between sarcoidosis and testicular carcinoma: a diagnostic pitfall. Sarcoidosis Vasc Diffuse Lung Dis 24(2):95–101PubMed
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Blacher EJ, Maynard JF (1985) Seminoma and sarcoidosis: an unusual association. Urology 26(3):288–289CrossRefPubMed
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Claus F, De Wever L, Moerman P (2012) Coincidence of seminoma and sarcoidosis in two patients presenting with peritoneal surface disease. Int J Urol 19(12):1126CrossRefPubMed
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Nonomura N, Nagahara A, Oka D, Mukai M, Nakai Y, Nakayama M et al (2009) Brain metastases from testicular germ cell tumors: a retrospective analysis. Int J Urol 16(11):887–893CrossRefPubMed
Metadata
Title
Granulomatous CNS inflammation associated with seminoma
Authors
Jennifer Massey
Susan Walker
Malcolm Galloway
Suran Fernando
John Parratt
Ann-Marie Quigley
Desmond P. Kidd
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 6/2019
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-019-09270-8

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