Skip to main content
Top
Published in: Journal of Neurology 7/2009

01-07-2009 | Letter to the Editors

Gene–gene interaction between CARD8 and interleukin-6 reduces Alzheimer’s disease risk

Authors: Ana Fontalba, Olga Gutiérrez, Javier Llorca, Ignacio Mateo, José Luis Vázquez-Higuera, José Berciano, José Luis Fernández-Luna, Onofre Combarros

Published in: Journal of Neurology | Issue 7/2009

Login to get access

Excerpt

Sirs, …
Literature
1.
go back to reference Combarros O, Infante J, Llorca J, Peña N, Fernández-Viadero C, Berciano J (2005) Interaction between interleukin-6 and intercellular adhesión molecule-1 genes and Alzheimer’s disease risk. J Neurol 252:485–487PubMedCrossRef Combarros O, Infante J, Llorca J, Peña N, Fernández-Viadero C, Berciano J (2005) Interaction between interleukin-6 and intercellular adhesión molecule-1 genes and Alzheimer’s disease risk. J Neurol 252:485–487PubMedCrossRef
2.
go back to reference Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369–1376PubMedCrossRef Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369–1376PubMedCrossRef
3.
go back to reference Fontalba A, Martinez-Taboada V, Gutierrez O, Pipaon C, Benito N, Balsa A, Blanco R, Fernandez-Luna JL (2007) Deficiency of the NF-κB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. J Immunol 179:4867–4873PubMed Fontalba A, Martinez-Taboada V, Gutierrez O, Pipaon C, Benito N, Balsa A, Blanco R, Fernandez-Luna JL (2007) Deficiency of the NF-κB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. J Immunol 179:4867–4873PubMed
4.
5.
go back to reference Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997) Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 94:2642–2647PubMedCrossRef Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997) Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 94:2642–2647PubMedCrossRef
6.
go back to reference McGovern DP, Butler H, Ahmad T, Paolucci M, van Heel DA, Negoro K, Hysi P, Ragoussis J, Travis SP, Cardon LR, Jewell DP (2006) TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology 131:1190–1196PubMedCrossRef McGovern DP, Butler H, Ahmad T, Paolucci M, van Heel DA, Negoro K, Hysi P, Ragoussis J, Travis SP, Cardon LR, Jewell DP (2006) TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology 131:1190–1196PubMedCrossRef
7.
go back to reference Pola R, Flex A, Gaetani E, Lago AD, Gerardino L, Pola P, Bernabei R (2002) The −174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer’s disease in an Italian population. Neuroreport 13:1645–1647PubMedCrossRef Pola R, Flex A, Gaetani E, Lago AD, Gerardino L, Pola P, Bernabei R (2002) The −174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer’s disease in an Italian population. Neuroreport 13:1645–1647PubMedCrossRef
8.
go back to reference Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Berting J, Alnemri ES (2002) CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem 277:13952–13958PubMedCrossRef Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Berting J, Alnemri ES (2002) CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem 277:13952–13958PubMedCrossRef
9.
go back to reference Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease: a double-edged sword. Neuron 35:419–432PubMedCrossRef Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease: a double-edged sword. Neuron 35:419–432PubMedCrossRef
Metadata
Title
Gene–gene interaction between CARD8 and interleukin-6 reduces Alzheimer’s disease risk
Authors
Ana Fontalba
Olga Gutiérrez
Javier Llorca
Ignacio Mateo
José Luis Vázquez-Higuera
José Berciano
José Luis Fernández-Luna
Onofre Combarros
Publication date
01-07-2009
Publisher
D. Steinkopff-Verlag
Published in
Journal of Neurology / Issue 7/2009
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-009-5080-z

Other articles of this Issue 7/2009

Journal of Neurology 7/2009 Go to the issue

Pioneers in Neurology

Costanzo Varolio (1543–1575)