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Lung
Published in: Lung 1/2014

01-02-2014

Chronic Cough and OSA: An Underappreciated Relationship

Authors: Krishna M. Sundar, Sarah E. Daly

Published in: Lung | Issue 1/2014

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Abstract

Chronic cough is increasingly being recognized as a process that has multiple initiating and perpetuating triggers. Obstructive sleep apnea has recently emerged as a possible disease that can lead to chronic cough. This review details the available clinical evidence that links these two disparate diseases and explores mechanistic bases of their relationship.
Literature
1.
2.
Irwin RS, Baumann MH, Bolser DC et al (2006) Diagnosis and management of cough executive summary: ACCP evidence-based practice guidelines. Chest 129:1S–23SPubMedCentralCrossRefPubMed
3.
Haque RA, Usmani OS, Barnes PJ (2005) Chronic idiopathic cough: a discrete clinical entity? Chest 127:1710–1713CrossRefPubMed
4.
Faruqi S, Molyneux ID, Fathi H, Wright C, Thompson R, Morice AH (2011) Chronic cough and esomeprazole: a double-blind placebo-controlled parallel study. Respirology 16:1150–1156CrossRefPubMed
5.
Shaheen NJ, Crockett SD, Bright SD et al (2011) Randomised clinical trial: high-dose acid suppression for chronic cough—a double blind, placebo-controlled study. Aliment Pharmacol Ther 33:225–234PubMedCentralCrossRefPubMed
6.
Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL (2006) Efficacy of speech pathology management for chronic cough: a randomized placebo controlled trial of treatment efficacy. Thorax 61:1065–1069PubMedCentralCrossRefPubMed
7.
Blondeau K, Dupont LJ, Mertens V et al (2007) Improved diagnosis of gastroesophageal reflux in patients with unexplained chronic cough. Aliment Pharmacol Ther 25:723–732CrossRefPubMed
8.
9.
Morice AH (2010) The cough hypersensitivity syndrome: a novel paradigm for understanding cough. Lung 188(Suppl 1):S87–S90CrossRefPubMed
10.
Chung KF (2011) Chronic “cough hypersensitivity syndrome”: a more precise label for chronic cough. Pulm Pharmacol Ther 24:267–271CrossRefPubMed
11.
Morice AH, McGarvey LPA, Dicpinigaitis PV (2012) Cough hypersensitivity syndrome is an important clinical concept: a pro/con debate. Lung 190:3–9CrossRefPubMed
12.
Palombini BC, Villanova CA, Araújo E, Gastal OL, Alt DC, Stolz DP, Palombini CO (1999) A pathogenic triad in chronic cough: asthma, postnasal drip syndrome and gastroesophageal reflux disease. Chest 116:279–284CrossRefPubMed
13.
Katle EJ, Hatlebakk JG, Steinsvaq S (2013) Gastroesophageal reflux and rhinosinusitis. Curr Allergy Asthma Rep 13:218–223CrossRefPubMed
14.
15.
Katz PO, Gerson LB, Vela MF (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108:308–328CrossRefPubMed
16.
17.
18.
Brightling CE (2011) Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction. Pulm Pharmacol Ther 24:324–327CrossRefPubMed
19.
Fox AJ, Lalloo UG, Belvisi MG, Bernareggi M, Chung KF, Barnes PJ (1996) Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE inhibitor cough. Nat Med 2:814–817CrossRefPubMed
20.
21.
Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM (2013) Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177:1006–1014
22.
Ojoo J, Everett CF, Mulrennan SA, Faruqi S, Kastelik KA, Morice AH (2013) Management of chronic cough using a clinical protocol: a prospective observational study. Cough 9:2PubMedCentralCrossRefPubMed
23.
Chan KKY, Ing AJ, Laks L, Cossa G, Rogers P, Birring SS (2010) Chronic cough in patients with sleep-disordered breathing. Eur Respir J 35:368–372CrossRefPubMed
24.
25.
Faruqi S, Fahim A, Morice AH (2012) Chronic cough and obstructive sleep apnoea: reflux-associated cough hypersensitivity? Eur Respir J 40:1049–1050CrossRefPubMed
26.
Brzecka A, Pawelec-Winiarz M, Piesiak P, Nowak E, Jankowska R (2011) Suppression of chronic nocturnal cough during continuous positive airway pressure (CPAP) treatment in a patient with asthma and obstructive sleep apnoea syndrome. Pneumonol Alergol Pol 79:121PubMed
27.
Mermigkis C, Bouloukaki I, Antoniou KM et al (2013) CPAP therapy in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea: does it offer a better quality of life and sleep? Sleep Breath 17:1137–1143
28.
Guglielminotti J, Tesniere A, Rackelboom T et al (2007) Cough reflex sensitivity is decreased in female obese patients with obstructive sleep apnea. Respir Physiol Neurobiol 158:83–87CrossRefPubMed
29.
Boyd JH, Petrof BJ, Hamid Q, Fraser R, Kimoff RJ (2004) Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J Respir Crit Care Med 170:541–546CrossRefPubMed
30.
31.
32.
33.
Kahrilas PJ (2010) Obstructive sleep apnea and reflux disease: bedfellows at best. Chest 137:747–748CrossRefPubMed
34.
Kuribiyashi S, Massey BT, Hafeezullah M et al (2010) Upper esophageal sphincter and gastroesophageal junction pressure changes act to prevent gastroesophageal and esophagopharyngeal reflux during apneic episodes with obstructive sleep apnea. Chest 137:769–776CrossRef
35.
Eastwood PR, Katagiri S, Shepherd KL, Hillman D (2007) Modulation of upper and lower esophageal sphincter tone during sleep. Sleep Med 8:135–143CrossRefPubMed
36.
Lee CH, Hong SL, Rhee CS, Kim SW, Kim JW (2009) Analysis of upper airway obstruction by sleep videoflouroscopy in obstructive sleep apnea: a large population-based study. Arch Otolaryngol Head Neck Surg 135:168–172CrossRefPubMed
37.
Nguyen AT, Jobin V, Payne R, Beauregard J, Naor N, Kimoff RJ (2005) Laryngeal and velopharyngeal sensory impairment in obstructive sleep apnea. Sleep 28:585–593PubMed
38.
Carpagnano GE, Spanevello A, Sabato R, Depalo A, Turchiarelli V, Foschino-Barbaro MP (2008) Exhaled pH, exhaled nitric oxide, and induced sputum cellularity in obese patients with obstructive sleep apnea syndrome. Transl Res 151:45–50CrossRefPubMed
39.
Sariman N, Levent E, Cubuk R, Yurdu S, Aksungar FB (2011) Bronchial hyperreactivity and airway wall thickening in obstructive sleep apnea patients. Sleep Breath 15:341–350CrossRefPubMed
40.
Ioachimescu OC, Teodorescu M (2013) Integrating the overlap of obstructive lung disease and obstructive sleep apnoea: OLDOSA syndrome. Respirology 18(3):421–431CrossRefPubMed
41.
Niimi A, Nguyen LT, Usmani O, Mann B, Chung KF (2004) Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax 59:608–612PubMedCentralCrossRefPubMed
42.
Matsumoto H, Niimi A, Tabeuna RP et al (2007) Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. Chest 131:1042–1049CrossRefPubMed
43.
44.
Metadata
Title
Chronic Cough and OSA: An Underappreciated Relationship
Authors
Krishna M. Sundar
Sarah E. Daly
Publication date
01-02-2014
Publisher
Springer US
Published in
Lung / Issue 1/2014
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-013-9534-9

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