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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 6/2022

Open Access 30-09-2021 | Schizophrenia | Invited Review

The role of microglia in neuropsychiatric disorders and suicide

Authors: Ralf Brisch, Szymon Wojtylak, Arthur Saniotis, Johann Steiner, Tomasz Gos, Jaliya Kumaratilake, Maciej Henneberg, Rainer Wolf

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 6/2022

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Abstract

This narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychiatric disorders is presented. This review focuses on results from postmortem, positron emission tomography (PET) imaging studies, and animal models of schizophrenia and depression. Third, the effects of antipsychotic and antidepressant drug therapy, and of electroconvulsive therapy on microglial cells are explored and the upcoming development of therapeutic drugs targeting microglia is described. Finally, there is a discussion on the role of microglia in the evolutionary progression of human lineage. This view may contribute to a new understanding of neuropsychiatric disorders.
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Metadata
Title
The role of microglia in neuropsychiatric disorders and suicide
Authors
Ralf Brisch
Szymon Wojtylak
Arthur Saniotis
Johann Steiner
Tomasz Gos
Jaliya Kumaratilake
Maciej Henneberg
Rainer Wolf
Publication date
30-09-2021
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 6/2022
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-021-01334-z

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