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European Archives of Psychiatry and Clinical Neuroscience

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01-06-2020 | Schizophrenia | Original Paper

Analysis of KCNH2 and CACNA1C schizophrenia risk genes on EEG functional network modulation during an auditory odd-ball task

Authors: Alba Lubeiro, Mar Fatjó-Vilas, Maria Guardiola, Carmen Almodóvar, Javier Gomez-Pilar, Benjamin Cea-Cañas, Jesús Poza, Aitor Palomino, Marta Gómez-García, Jone Zugasti, Vicente Molina

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 4/2020

Abstract

A deficit in task-related functional connectivity modulation from electroencephalogram (EEG) has been described in schizophrenia. The use of measures of neuronal connectivity as an intermediate phenotype may allow identifying genetic factors involved in these deficits, and therefore, establishing underlying pathophysiological mechanisms. Genes involved in neuronal excitability and previously associated with the risk for schizophrenia may be adequate candidates in relation to functional connectivity alterations in schizophrenia. The objective was to study the association of two genes of voltage-gated ion channels (CACNA1C and KCNH2) with the functional modulation of the cortical networks measured with EEG and graph-theory parameter during a cognitive task, both in individuals with schizophrenia and healthy controls. Both CACNA1C (rs1006737) and KCNH2 (rs3800779) were genotyped in 101 controls and 50 schizophrenia patients. Small-world index (SW) was calculated from EEG recorded during an odd-ball task in two different temporal windows (pre-stimulus and response). Modulation was defined as the difference in SW between both windows. Genetic, group and their interaction effects on SW in the pre-stimulus window and in modulation were evaluated using ANOVA. The CACNA1C genotype was not associated with SW properties. KCNH2 was significantly associated with SW modulation. Healthy subjects showed a positive SW modulation irrespective of the KCNH2 genotype, whereas within patients allele-related differences were observed. Patients carrying the KCNH2 risk allele (A) presented a negative SW modulation and non-carriers showed SW modulation similar to the healthy subjects. Our data suggest that KCNH2 genotype contributes to the efficient modulation of brain electrophysiological activity during a cognitive task in schizophrenia patients.

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Title: Analysis of KCNH2 and CACNA1C schizophrenia risk genes on EEG functional network modulation during an auditory odd-ball task
Authors: Alba Lubeiro
Mar Fatjó-Vilas
Maria Guardiola
Carmen Almodóvar
Javier Gomez-Pilar
Benjamin Cea-Cañas
Jesús Poza
Aitor Palomino
Marta Gómez-García
Jone Zugasti
Vicente Molina
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keyword: Schizophrenia
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 4/2020
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-018-0977-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Analysis of KCNH2 and CACNA1C schizophrenia risk genes on EEG functional network modulation during an auditory odd-ball task

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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