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European Archives of Oto-Rhino-Laryngology

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01-10-2018 | Rhinology

The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model

Authors: Muhammed Sedat Sakat, Korhan Kilic, Fatih Mehmet Kandemir, Serkan Yildirim, Abdulkadir Sahin, Sefa Kucukler, Yavuz Selim Saglam

Published in: European Archives of Oto-Rhino-Laryngology | Issue 10/2018

Abstract

Purpose

Berberine and coenzyme Q10 (CoQ10) are agents with anti-inflammatory and antioxidant characteristics. The purpose of this study was to investigate the effectiveness of berberine and CoQ10 on allergic rhinitis.

Methods

This study involved 30 Sprague–Dawley rats, and allergic rhinitis model was established with induction of ovalbumin. Rats were randomized into five groups. The first represented the control group, in which no allergy was established. The second represented the allergy group, in which allergy was induced but no treatment was given. In the remaining three groups, following induction of allergy, desloratadine at a dose of 10 mg/kg was given to Group 3, 100 mg/kg dose of berberine to Group 4, and 20 mg/kg dose of CoQ10 to Group 5. Nasal symptom scores, and plasma immunoglobulin-E, interleukin (IL)-4, IL-13, malondialdehyde (MDA) and nitric oxide (NO) levels were examined at the end of the study. Rats’ nasal tissues were also subjected to histopathological immunohistochemical examination.

Results

Nasal symptom scores, and plasma immunoglobulin-E, IL-4, IL-13, MDA and NO levels increased significantly in rats with induced allergic rhinitis. Berberine and CoQ10 significantly reduced these elevated levels. CoQ10 was also found as effective as desloratadin in terms of nasal symptom scores and biochemical parameters. At histopathological examination, severe allergic inflammation was observed in rats from allergic rhinitis group. At all treatment groups, the histopathological changes were significantly improved and only a mild inflammation was determined. Also, immunochemistry showed a significant improvement in all three treatment groups. Coenzyme Q10 and berberine were both effective in suppressing allergy symptoms.

Conclusion

We think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model.

Brożek JL, Bousquet J, Baena-Cagnani CE et al (2010) Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 126:466–476CrossRefPubMed

Kakli HA, Riley TD (2016) Allergic rhinitis. Prim Care 43:465–475CrossRefPubMed

Wang Z, Chen Z, Chen T el al (2017) Berberine attenuates inflammation associated with delayed-type hypersensitivity via suppressing Th1 response and inhibiting apoptosis. Inflammation 40:221–231CrossRefPubMed

Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P (2018) Coenzyme Q(10) supplementation in aging and disease. Front Physiol 9:44CrossRefPubMedPubMedCentral

Tatar A, Yayla M, Kose D et al (2016) The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model. Rhinology 54:266–272CrossRefPubMed

Senturk E, Yildirim YS, Dogan R et al (2018) Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis. Eur Arch Otorhinolaryngol 275:117–124CrossRefPubMed

Placer ZA, Cushman L, Johnson BC (1966) Estimation of products of lipid peroxidation (malonyl dialdehyde) in biological fluids. Anal Biochem 16:359–364CrossRefPubMed

Ridolo E, Martignago I, Masieri S (2018) Mechanisms of allergic diseases in Otorhinolaryngology. J Biol Regul Homeost Agents 32:9–12PubMed

Sagit M, Polat H, Gurgen SG et al (2017) Effectiveness of quercetin in an experimental rat model of allergic rhinitis. Eur Arch Otorhinolaryngol 274:3087–3095CrossRefPubMed

10.

Yu S, Zhao C, Che N et al (2017) Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress. J Inflamm (Lond) 14:1–12CrossRef

11.

Yman L (2001) Standardization of in vitro methods. Allergy 67:70–74CrossRef

12.

Winther L, Moseholm L, Reimert CM et al (1999) Basophil histamine release, IgE, eosinophil counts, ECP, and EPX are related to the severity of symptoms in seasonal allergic rhinitis. Allergy 54:436–445CrossRefPubMed

13.

Meng Y, Lou H, Wang Y et al (2018) The use of specific immunoglobulin E in nasal secretions for the diagnosis of allergic rhinitis. Laryngoscope. https://doi.org/10.1002/lary.27120 PubMedCrossRef

14.

Tachdjian R, Mathias C, Al Khatib S et al (2009) Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med 206:2191–2204CrossRefPubMedPubMedCentral

15.

Zhao C, Yu S, Li J et al (2017) Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model. Allergol Immunopathol (Madr) 45:350–355CrossRef

16.

Choi SP, Oh HN, Choi CY et al (2018) Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice. J Appl Microbiol 124:821–828CrossRefPubMed

17.

Carson JL, Hernandez M, Jaspers I et al (2018) Interleukin-13 stimulates production of nitric oxide in cultured human nasal epithelium. In Vitro Cell Dev Biol Anim 54:200–204CrossRefPubMed

18.

Hou J, Lou H, Wang Y et al (2018) Nasal ventilation is an important factor in evaluating the diagnostic value of nasal nitric oxide in allergic rhinitis. Int Forum Allergy Rhinol. https://doi.org/10.1002/alr.22087 PubMedCrossRef

19.

Arnal JF, Didier A, Rami J et al (1997) Nasal nitric oxide is increased in allergic rhinitis. Clin Exp Allergy 27:358–362CrossRefPubMed

20.

Suojalehto H, Vehmas T, Lindstrom I et al (2014) Nasal nitric oxide is dependent on sinus obstruction in allergicrhinitis. Laryngoscope 124:E213–E218CrossRefPubMed

21.

Alexanderson C, Olin AC, Dahlman-Hoglund A et al (2012) Nasal nitric oxide in a random sample of adults and its relationship to sensitization, cat allergen, rhinitis, and ambient nitric oxide. Am J Rhinol Allergy 26:e99–e103CrossRefPubMedPubMedCentral

22.

Ulusoy S, Ayan NN, Dinc ME et al (2016) A new oxidative stress marker for thiol-disulphide homeostasis in seasonal allergic rhinitis. Am J Rhinol Allergy 30:53–57CrossRefPubMed

23.

Alam MA, Rahman MM (2014) Mitochondrial dysfunction in obesity: potential benefit and mechanism of co-enzyme Q10 supplementation in metabolic syndrome. J Diabetes Metab Disord 13:60CrossRefPubMedPubMedCentral

24.

Farrag SM, Hamzawy MA, El-Yamany MF et al (2018) Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats. Life Sci 203:129–140CrossRefPubMed

25.

Mustafa HN, Hegazy GA, Awdan SAE, Abdel Baset M (2017) Protective role of CoQ10 or l-carnitine on the integrity of the myocardium in doxorubicin induced toxicity. Tissue Cell 49:410–426CrossRefPubMed

26.

Gvozdjáková A, Kucharská J, Bartkovjaková M et al (2005) Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma. Biofactors 25:235–240CrossRefPubMed

27.

Yakin M, Eksioglu U, Sadic M et al (2017) Coenzyme Q10 for the protection of lacrimal gland against high-dose radioiodine therapy-associated oxidative damage: histopathologic and tissue cytokine level assessments in an animal model. Curr Eye Res 42:1590–1596CrossRefPubMed

28.

Li Z, Zheng J, Zhang N, Li C (2016) Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma. J Asthma 53:999–1005CrossRefPubMed

29.

Kim BY, Park HR, Jeong HG, Kim SW (2015) Berberine reduce allergic inflammation in a house dust mite allergic rhinitis mouse model. Rhinology 53:353–358CrossRefPubMed

30.

Mehrzadi S, Fatemi I, Esmaeilizadeh M et al (2018) Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomed Pharmacother 97:233–239CrossRefPubMed

31.

Xiong C, Wu YZ, Zhang Y et al (2018) Protective effect of berberine on acute cardiomyopathy associated with doxorubicin treatment. Oncol Lett 15:5721–5729PubMedPubMedCentral

Title: The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model
Authors: Muhammed Sedat Sakat
Korhan Kilic
Fatih Mehmet Kandemir
Serkan Yildirim
Abdulkadir Sahin
Sefa Kucukler
Yavuz Selim Saglam
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 10/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5104-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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