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European Archives of Oto-Rhino-Laryngology

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01-01-2018 | Rhinology

Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis

Authors: Erol Senturk, Yavuz Selim Yildirim, Remzi Dogan, Orhan Ozturan, Eray Metin Guler, Mehmet Serif Aydin, Abdurrahim Kocyigit, Mukaddes Esrefoglu, Ilker Kocak

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2018

Abstract

The aim of this study is to show if cyclosporine has an antiallergic role in a rat model of ovalbumin-induced allergic rhinitis. The 54 rats were divided into six equal groups. The first group was a negative control group without induced allergic rhinitis; the second group a positive control with induced allergic rhinitis not receiving treatment. The remaining four groups, after induction of allergic rhinitis, received intranasal cyclosporine treatment in doses of 0.05, 0.1, or 0.2% or nasal steroid treatment. In the biochemical examination, on the surface of the tissue tumor necrosis factor (TNF) interferon (IFN), interleukin (IL)-5, IL-13, as well as IL-2, IL-4, IL-17A, and IgE were studied. Histologically, ciliary loss, increase of goblet cells, vascular congestion, and the degree of eosinophil infiltration were rated. In all treatment groups, on average, a significant reduction in all histological and biochemical values was found compared to the positive control group. Comparing each of the three cyclosporine-using groups with the group of nasal corticosteroid did not show any significant difference in the average scores. Cyclosporine nasal drops are effective to be used in an animal model of experimental allergic rhinitis without systemic effects.

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Title: Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis
Authors: Erol Senturk
Yavuz Selim Yildirim
Remzi Dogan
Orhan Ozturan
Eray Metin Guler
Mehmet Serif Aydin
Abdurrahim Kocyigit
Mukaddes Esrefoglu
Ilker Kocak
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-017-4786-2

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Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis

Abstract

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Abstract

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