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European Archives of Oto-Rhino-Laryngology

Published in:

01-07-2018 | Review Article

Polymorphous adenocarcinoma of the salivary glands: reappraisal and update

Authors: Vincent Vander Poorten, Asterios Triantafyllou, Alena Skálová, Göran Stenman, Justin A. Bishop, Esther Hauben, Jennifer L. Hunt, Henrik Hellquist, Simon Feys, Remco De Bree, Antti A. Mäkitie, Miquel Quer, Primož Strojan, Orlando Guntinas-Lichius, Alessandra Rinaldo, Alfio Ferlito

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2018

Abstract

Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.

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Title: Polymorphous adenocarcinoma of the salivary glands: reappraisal and update
Authors: Vincent Vander Poorten
Asterios Triantafyllou
Alena Skálová
Göran Stenman
Justin A. Bishop
Esther Hauben
Jennifer L. Hunt
Henrik Hellquist
Simon Feys
Remco De Bree
Antti A. Mäkitie
Miquel Quer
Primož Strojan
Orlando Guntinas-Lichius
Alessandra Rinaldo
Alfio Ferlito
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 7/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-4985-5

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Polymorphous adenocarcinoma of the salivary glands: reappraisal and update

Abstract

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Abstract

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