Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 2/2018

01-02-2018 | Head and Neck

Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer

Authors: Yize Mao, Yan Fu, Yunfei Gao, Ankui Yang, Quan Zhang

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2018

Login to get access

Abstract

Objectives

Although the survival rate of laryngeal cancer is relatively high, some patients with laryngeal squamous cell carcinoma (LSCC) show the least benefit from laryngectomy, owing to few determining diagnostic tools. We aimed to identify high-risk patients according to a preoperatively determined signature of the platelet-to-lymphocyte ratio (PLR) of > 193.55, as an indicator of poor treatment outcome in LSCC patients.

Methods

We retrospectively evaluated 899 patients who underwent laryngectomy for LSCC. The patients were stratified by PLR into three subgroups: low (≤ 119.55), moderate (> 119.55 and ≤ 193.55), and high (> 193.55). Kaplan–Meier curves were plotted to compare the intergroup cancer-specific survival (CSS).

Results

Patients with high PLR had significantly worse survival outcomes (5-year CSS, low vs. moderate vs. high: 75.3 vs. 68.4 vs. 53.9%; 10-year CSS, low vs. moderate vs. high: 65.0 vs. 56.0 vs. 38.6%, P < 0.001). Patients with PLR > 193.55 represented malnutrition and more advanced cancer stage..

Conclusion

Patients with PLR > 193.55 experience poor outcomes and represent malnutrition, more advanced cancer stage.
Appendix
Available only for authorised users
Literature
1.
2.
Carvalho AL, Nishimoto IN, Califano JA, Kowalski LP(2005) Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer 114:806–816CrossRefPubMed
3.
Connor KL, Pattle S, Kerr GR, Junor E (2015) Treatment, comorbidity and survival in stage III laryngeal cancer. Head Neck 37:698–706CrossRefPubMed
4.
Hoffman HT, Porter K, Karnell LH et al (2006) Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 116:1–13CrossRefPubMed
5.
6.
van Oijen MG, Slootweg PJ (2000) Gain-of-function mutations in the tumor suppressor gene p53. Clin Cancer Res 6:2138–2145PubMed
7.
Trask DK, Wolf GT, Bradford CR et al. (2002) Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation. Laryngoscope 112:638–644CrossRefPubMed
8.
Maurizi M, Almadori G, Ferrandina G et al (1996) Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. Br J Cancer 74:1253–1257CrossRefPubMedPubMedCentral
9.
Chen J, Zhou J, Lu J, Xiong H, Shi X, Gong L (2014) Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis. BMC Cancer 14:15CrossRefPubMedPubMedCentral
10.
11.
Gomez D, Farid S, Malik HZ et al (2008) Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 32:1757–1762CrossRefPubMed
12.
McMillan DC, Canna K, McArdle CS (2003) Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 90:215–219CrossRefPubMed
13.
Izano M, Wei EK, Tai C et al (2016) Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study. Int J Cancer 138:1118–1128CrossRefPubMed
14.
Klinger MH, Jelkmann W.(2002) Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 22:913–922CrossRefPubMed
15.
Salazar-Onfray F, Lopez MN, Mendoza-Naranjo A.(2007) Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Fact Rev 18:171–182CrossRef
16.
Clarke SJ, Chua W, Moore M et al (2011) Use of inflammatory markers to guide cancer treatment. Clin Pharmacol Ther 90:475–478CrossRefPubMed
17.
Templeton AJ, Ace O, McNamara MG et al (2014) Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomark Preven Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 23:1204–1212CrossRef
18.
Krenn-Pilko S, Langsenlehner U, Thurner EM et al (2014) The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients. Br J Cancer 110:2524–2530CrossRefPubMedPubMedCentral
19.
Ozawa T, Ishihara S, Nishikawa T et al (2015) The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer. Int J Colorectal Dis 30:1165–1171CrossRefPubMed
20.
Kara M, Uysal S, Altinisik U, Cevizci S, Guclu O, Derekoy FS.(2017) The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 274:535–542CrossRefPubMed
21.
Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471–1474CrossRefPubMed
22.
Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10:7252–7259CrossRefPubMed
23.
Fu Y, Liu W, OuYang D, Yang A, Zhang Q (2016) Preoperative neutrophil-to-lymphocyte ratio predicts long-term survival in patients undergoing total laryngectomy with advanced laryngeal squamous cell carcinoma: a single-center retrospective study. Medicine 95:e2689CrossRefPubMedPubMedCentral
24.
Fu Y, Mao Y, Chen S, Yang A, Zhang Q (2016) A novel inflammation- and nutrition-based prognostic system for patients with laryngeal squamous cell carcinoma: combination of red blood cell distribution width and body mass index (COR-BMI). PLoS One 11:e0163282CrossRefPubMedPubMedCentral
25.
26.
27.
Silvis SE, Turkbas N, Doscherholmen A (1970) Thrombocytosis in patients with lung cancer. JAMA 211:1852–1853CrossRefPubMed
28.
Takahashi Y, Bucana CD, Akagi Y et al. (1998) Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin Cancer Res 4:429–434PubMed
29.
Gislason T, Nou E (1985) Sedimentation rate, leucocytes, platelet count and haemoglobin in bronchial carcinoma: an epidemiological study. Eur J Respirat Di 66:141–146
30.
el-Hag A, Clark RA (1987) Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J Immunol 139:2406–2413PubMed
31.
Wu G, Yao Y, Bai C et al. (2015) Combination of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio is a useful prognostic factor in advanced non-small cell lung cancer patients. Thoracic cancer 6:275–287CrossRefPubMedPubMedCentral
32.
Feng JF, Huang Y, Liu JS (2013) Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. OncoTargets Ther 6:1605–1612
33.
Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A (2013) The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma. J Surg Oncol 108:481–485CrossRefPubMed
34.
Nagaoka S, Yoshida T, Akiyoshi J et al (2007) Serum C-reactive protein levels predict survival in hepatocellular carcinoma. Liver Int 27:1091–1097CrossRefPubMed
35.
Yalcinkaya E, Bugan B, Celik M, Yasar S, Gursoy E (2013) Neutrophil lymphocyte ratio should be assessed together with other inflammatory markers and confounding factors. Eur Rev Med Pharmacol Sci 17:2410PubMed
Metadata
Title
Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer
Authors
Yize Mao
Yan Fu
Yunfei Gao
Ankui Yang
Quan Zhang
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 2/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-017-4849-4

Other articles of this Issue 2/2018

European Archives of Oto-Rhino-Laryngology 2/2018 Go to the issue

Laryngology

Continuum theory: presbyphagia to dysphagia? Functional assessment of swallowing in the elderly

Miscellaneous

Early prelingual auditory development in Italian infants and toddlers analysed through the Italian version of the Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS)

Letter to the Editor

Nasal packing and trans-septal suturing after septoplasty

Head and Neck

Nasopharyngeal carcinoma: relationship between invasion of the prevertebral space and distant metastases

Otology

3D endoscopic ear surgery: a clinical pilot study

Rhinology

The role of YKL40 in the pathogenesis of CRS with nasal polyps