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01-07-2019 | Fertility | Review

Short- and long term outcomes after abdominal radical trachelectomy versus radical hysterectomy for early stage cervical cancer: a systematic review of the literature and meta-analysis

Authors: Anastasia Prodromidou, Christos Iavazzo, Alexandros Fotiou, Victoria Psomiadou, Athanasios Douligeris, Georgios Vorgias, Nikolaos Kalinoglou

Published in: Archives of Gynecology and Obstetrics | Issue 1/2019

Abstract

Purpose

Cervical cancer (CC) ranks 2nd for mortality among women of reproductive age in the United States. Abdominal radical trachelectomy (ART) is a fertility sparing approach that has been proposed in women with early stage CC who wish to preserve their fertility. The aim of the present meta-analysis was to evaluate the short- and long-term outcomes of RH vs ART for early stage CC.

Methods

A total of 5 electronic databases were searched for articles published up to December 2018. Prospective and retrospective trials reporting outcomes for women who underwent ART or RH for the management of early stages CC, were considered eligible for inclusion. Statistical meta-analysis was performed using the RevMan 5.3 software.

Results

A total of 5 studies which included 840 women who underwent ART or radical trachelectomy (RH) were included in the present meta-analysis. Among them, 324 underwent ART whereas the remaining 516 had RH. Despite the fact that ART was associated with significantly prolonged operative time compared to RH (840 patients MD 36.82 min, 95% CI 20.15–53.49, p < 0.001), neither 5-year OS nor 5-year DFS were different among the two groups (714 patients OR 1.39, 95% CI 0.53–3.62, p = 0.51 and 682 patients OR 1.08, 95% CI 0.52–2.25, p = 0.84, respectively).

Conclusions

ART is a more complex and time consuming technique, but equally safe compared to RH in terms of oncological outcomes for selected women with early stage CC and allows for more CC survivors of childbearing age to preserve their fertility.

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Title: Short- and long term outcomes after abdominal radical trachelectomy versus radical hysterectomy for early stage cervical cancer: a systematic review of the literature and meta-analysis
Authors: Anastasia Prodromidou
Christos Iavazzo
Alexandros Fotiou
Victoria Psomiadou
Athanasios Douligeris
Georgios Vorgias
Nikolaos Kalinoglou
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keywords: Fertility
Cervical Cancer
Cervical Cancer
Radical Trachelectomy
Hysterectomy
Published in: Archives of Gynecology and Obstetrics / Issue 1/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05176-y

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Short- and long term outcomes after abdominal radical trachelectomy versus radical hysterectomy for early stage cervical cancer: a systematic review of the literature and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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