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01-05-2019 | Premature Birth | Maternal-Fetal Medicine

Prevention of spontaneous preterm birth

Authors: George Daskalakis, Maria Goya, Vasilios Pergialiotis, Luis Cabero, Ioannis Kyvernitakis, Aris Antsaklis, Birgit Arabin

Published in: Archives of Gynecology and Obstetrics | Issue 5/2019

Abstract

Background

It is estimated that globally, approximately 13 million preterm infants are born annually and a much higher number of pregnancies are characterized by threatening preterm birth.

Findings

A proportional inverse correlation between gestational age at delivery and neonatal mortality has been observed which is more prevalent in countries without high standard neonatal care. The socioeconomic burden of preterm birth is enormous, as preterm neonates are particularly prone to severe morbidity that may expand up to adulthood. Several strategies have been proposed for the prevention of preterm birth which can be sub-stratified as primary (when these apply to the general population), secondary (when they target women at risk), and tertiary (optimizing neonatal outcomes when preterm birth cannot any longer be prevented). The aim of this review is to summarize the most important strategies.

Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH et al (2010) The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 88(1):31–38CrossRefPubMed

Steer P (2005) The epidemiology of preterm labour. BJOG Int J Obstet Gynaecol 112(Suppl 1):1–3

Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379(9832):2162–2172CrossRefPubMed

Zeitlin J, Szamotulska K, Drewniak N, Mohangoo AD, Chalmers J, Sakkeus L et al (2013) Preterm birth time trends in Europe: a study of 19 countries. BJOG Int J Obstet Gynaecol 120(11):1356–1365CrossRef

Diez-Izquierdo A, Balaguer A, Lidon-Moyano C, Martin-Sanchez JC, Galan I, Fernandez E et al (2018) Correlation between tobacco control policies and preterm births and low birth weight in Europe. Environ Res 160:547–553CrossRefPubMed

Lawn JE, Cousens S, Zupan J (2005) 4 million neonatal deaths: when? Where? Why? Lancet (London, England) 365(9462):891–900CrossRef

Saigal S, Doyle LW (2008) An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet (London, England) 371(9608):261–269CrossRef

Goldenberg RL, Culhane JF, Iams JD, Romero R (2008) Epidemiology and causes of preterm birth. Lancet (London, England) 371(9606):75–84CrossRef

Fuchs F, Monet B, Ducruet T, Chaillet N, Audibert F (2018) Effect of maternal age on the risk of preterm birth: a large cohort study. PLoS One. 13(1):e0191002-eCrossRef

10.

Goisis A, Remes H, Barclay K, Martikainen P, Myrskyla M (2017) Advanced maternal age and the risk of low birth weight and preterm delivery: a within-family analysis using finnish population registers. Am J Epidemiol 186(11):1219–1226CrossRefPubMedPubMedCentral

11.

Lucovnik M, Bregar AT, Steblovnik L, Verdenik I, Gersak K, Blickstein I et al (2016) Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study. J Perinat Med 44(5):505–509CrossRefPubMed

12.

Lisonkova S, Hutcheon JA, Joseph KS (2011) Temporal trends in neonatal outcomes following iatrogenic preterm delivery. BMC Pregnancy Childbirth 11:39CrossRefPubMedPubMedCentral

13.

Getahun D, Demissie K, Marcella SW, Rhoads GG (2014) The impact of changes in preterm birth among twins on stillbirth and infant mortality in the United States. J Perinatol Off J Calif Perinat Assoc 34(11):823–829

14.

Romero R, Dey SK, Fisher SJ (2014) Preterm labor: one syndrome, many causes. Science 345(6198):760–765CrossRefPubMedPubMedCentral

15.

Shiono PH, Klebanoff MA, Rhoads GG (1986) Smoking and drinking during pregnancy. Their effects on preterm birth. JAMA 255(1):82–84CrossRefPubMed

16.

Cnattingius S, Forman MR, Berendes HW, Graubard BI, Isotalo L (1993) Effect of age, parity, and smoking on pregnancy outcome: a population-based study. Am J Obstet Gynecol 168(1 Pt 1):16–21CrossRefPubMed

17.

Harlow BL, Frigoletto FD, Cramer DW, Evans JK, LeFevre ML, Bain RP et al (1996) Determinants of preterm delivery in low-risk pregnancies. The RADIUS Study Group. J Clin Epidemiol 49(4):441–448CrossRefPubMed

18.

Kyrklund-Blomberg NB, Cnattingius S (1998) Preterm birth and maternal smoking: risks related to gestational age and onset of delivery. Am J Obstet Gynecol 179(4):1051–1055CrossRefPubMed

19.

Been JV, Nurmatov UB, Cox B, Nawrot TS, van Schayck CP, Sheikh A (2015) Effect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis. Eur J Paediatr Dent Off J Eur Acad Paediatr Dent 16(3):210–211

20.

Been JV, Nurmatov UB, Cox B, Nawrot TS, van Schayck CP, Sheikh A (2014) Effect of smoke-free legislation on perinatal and child health: a systematic review and meta-analysis. Lancet 383(9928):1549–1560CrossRefPubMed

21.

Hiersch L, Rosen H, Okby R, Freeman H, Barrett J, Melamed N (2016) The greater risk of preterm birth in triplets is mirrored by a more rapid cervical shortening along gestation. Am J Obstet Gynecol 215(3):357.e1–357.e6CrossRef

22.

Bebbington M (2014) Selective reduction in multiple gestations. Best Pract Res Clin Obstet Gynaecol 28(2):239–247CrossRefPubMed

23.

Harbottle S, Hughes C, Cutting R, Roberts S, Brison D (2015) Elective single embryo transfer: an update to UK best practice guidelines. Hum Fertil (Cambridge, England) 18(3):165–183CrossRef

24.

Joint SOGC-CFAS (2008) Guidelines for the number of embryos to transfer following in vitro fertilization No. 182 September 2006. Int J Gynaecol Obstet 102(2):203–216CrossRef

25.

Cavoretto P, Candiani M, Giorgione V, Inversetti A, Abu-Saba MM, Tiberio F et al (2018) Risk of spontaneous preterm birth in singleton pregnancies conceived after IVF/ICSI treatment: meta-analysis of cohort studies. Ultrasound Obstet Gynecol 51(1):43–53CrossRefPubMed

26.

Halliday-Bell JA, Quansah R, Gissler M, Jaakkola JJ (2010) Laboratory work and adverse pregnancy outcomes. Occup Med (Oxford, England) 60(4):310–313CrossRef

27.

Palmer KT, Bonzini M, Harris EC, Linaker C, Bonde JP (2013) Work activities and risk of prematurity, low birthweight and pre-eclampsia: an updated review with meta-analysis. Occup Environ Med 70(4):213–222CrossRefPubMed

28.

Christiaens I, Hegadoren K, Olson DM (2015) Adverse childhood experiences are associated with spontaneous preterm birth: a case–control study. BMC Med 13:124CrossRefPubMedPubMedCentral

29.

Faraji J, Soltanpour N, Lotfi H, Moeeini R, Moharreri AR, Roudaki S et al (2017) Lack of social support raises stress vulnerability in rats with a history of ancestral stress. Sci Rep 7(1):5277CrossRefPubMedPubMedCentral

30.

Olson DM, Severson EM, Verstraeten BS, Ng JW, McCreary JK, Metz GA (2015) Allostatic load and preterm birth. Int J Mol Sci 16(12):29856–29874CrossRefPubMedPubMedCentral

31.

Mikkelsen TB, Osterdal ML, Knudsen VK, Haugen M, Meltzer HM, Bakketeig L et al (2008) Association between a Mediterranean-type diet and risk of preterm birth among Danish women: a prospective cohort study. Acta obstetricia et gynecologica Scandinavica 87(3):325–330CrossRefPubMed

32.

Parlapani E, Agakidis C, Karagiozoglou-Lampoudi T, Sarafidis K, Agakidou E, Athanasiadis A et al (2017) The Mediterranean diet adherence by pregnant women delivering prematurely: association with size at birth and complications of prematurity. J Maternal Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 32:1–8

33.

Hegelund ER, Urhoj SK, Andersen AN, Mortensen LH (2018) Interpregnancy interval and risk of adverse pregnancy outcomes: a register-based study of 328,577 pregnancies in Denmark 1994–2010. Maternal Child Health J 22(7):1008–1015CrossRef

34.

Kuwahara M, Yamasato K, Tschann M, Kaneshiro B (2018) Interpregnancy interval and subsequent pregnancy outcomes after dilation and evacuation. J Obstet Gynaecol J Inst Obstet Gynaeco 38(4):516–520CrossRef

35.

Mannisto J, Bloigu A, Mentula M, Gissler M, Heikinheimo O, Niinimaki M (2017) Interpregnancy Interval after termination of pregnancy and the risks of adverse outcomes in subsequent birth. Obstet Gynecol 129(2):347–354CrossRefPubMed

36.

Medley N, Vogel JP, Care A, Alfirevic Z (2018) Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 11:CD012505PubMed

37.

Sotiriadis A, Papatheodorou S, Kavvadias A, Makrydimas G (2010) Transvaginal cervical length measurement for prediction of preterm birth in women with threatened preterm labor: a meta-analysis. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 35(1):54–64CrossRef

38.

Lim AC, Hegeman MA, HuisIn ‘T Veld MA, Opmeer BC, Bruinse HW, Mol BWJ (2011) Cervical length measurement for the prediction of preterm birth in multiple pregnancies: a systematic review and bivariate meta-analysis. Ultrasound Obstet Gynecol 38(1):10–17CrossRefPubMed

39.

Kyvernitakis I, Maul H, Bahlmann F (2018) Controversies about the secondary prevention of spontaneous preterm birth. Geburtshilfe und Frauenheilkunde 78(6):585–595CrossRefPubMedPubMedCentral

40.

Kyvernitakis I, Arabin B (2017) Re: Prevention of preterm birth with pessary in twins (PoPPT): a randomized controlled trial. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 50(3):408–409CrossRef

41.

Fanca MS HT, Hatanaka AR, Mattar R, Moron AF (2015) The importance of learning curve in practice of cervical pessary. In: 14th World Congress in Fetal Medicine; Crete, Greece

42.

Cannie MM, Dobrescu O, Gucciardo L, Strizek B, Ziane S, Sakkas E et al (2013) Arabin cervical pessary in women at high risk of preterm birth: a magnetic resonance imaging observational follow-up study. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 42(4):426–433

43.

Mendoza M, Goya M, Gascon A, Pratcorona L, Merced C, Rodo C et al (2017) Modification of cervical length after cervical pessary insertion: correlation weeks of gestation. J Matern Fetal Neonat Med 30(13):1596–1601CrossRef

44.

Arabin B, Halbesma JR, Vork F, Hubener M, van Eyck J (2003) Is treatment with vaginal pessaries an option in patients with a sonographically detected short cervix? J Perinat Med 31(2):122–133CrossRefPubMed

45.

Nicolaides KH, Syngelaki A, Poon LC, Picciarelli G, Tul N, Zamprakou A et al (2016) A randomized trial of a cervical pessary to prevent preterm singleton birth. N Engl J Med 374(11):1044–1052CrossRefPubMed

46.

Goya M, Pratcorona L, Higueras T, Perez-Hoyos S, Carreras E, Cabero L (2011) Sonographic cervical length measurement in pregnant women with a cervical pessary. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 38(2):205–209CrossRef

47.

Saccone G, Maruotti GM, Giudicepietro A, Martinelli P, Italian Preterm Birth Prevention Working G (2017) Effect of cervical pessary on spontaneous preterm birth in women with singleton pregnancies and short cervical length: a randomized clinical trial. JAMA J Am Med Assoc 318(23):2317–2324CrossRef

48.

Hui SY, Chor CM, Lau TK, Lao TT, Leung TY (2012) Cerclage pessary for preventing preterm birth in women with a singleton pregnancy and a short cervix at 20 to 24 weeks: a randomized controlled trial. Am J Perinatol 30:283–288CrossRefPubMed

49.

Karbasian N, Sheikh M, Pirjani R, Hazrati S, Tara F, Hantoushzadeh S (2016) Combined treatment with cervical pessary and vaginal progesterone for the prevention of preterm birth: a randomized clinical trial. J Obstet Gynaecol Res 42(12):1673–1679CrossRefPubMed

50.

Dugoff L, Berghella V, Sehdev H, Mackeen AD, Goetzl L, Ludmir J (2018) Prevention of preterm birth with pessary in singletons (PoPPS): randomized controlled trial. Ultrasound Obstet Gynecol 51(5):573–579CrossRefPubMed

51.

Melcer Y, Kovo M, Maymon R, Bar J, Wiener I, Neeman O et al (2019) Arabin cervical pessary with vaginal progesterone versus vaginal progesterone for preventing preterm delivery. J Matern Fetal Neonat Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 2019:1–131

52.

Pratcorona L, Goya M, Merced C, Rodo C, Llurba E, Higueras T et al (2018) Cervical pessary to reduce preterm birth <34 weeks of gestation after an episode of preterm labor and a short cervix: a randomized controlled trial. Am J Obstet Gynecol 219(1):99e1–99e16CrossRef

53.

Hermans FJR, Schuit E, Bekker MN, Woiski M, de Boer MA, Sueters M et al (2018) Cervical pessary after arrested preterm labor: a randomized controlled trial. Obstet Gynecol 132(3):741–749CrossRefPubMed

54.

Care A, Muller-Myhsok B, Olearo E, Todros T, Caradeux J, Goya M et al (2018) Can previous preterm birth classification influence treatment of short cervix in a subsequent pregnancy? Comparison of vaginal progesterone and Arabin pessary. Ultrasound Obstet Gynecol. https://doi.org/10.1002/uog.19118 CrossRef

55.

Liem S, Schuit E, Hegeman M, Bais J, de Boer K, Bloemenkamp K et al (2013) Cervical pessaries for prevention of preterm birth in women with a multiple pregnancy (ProTWIN): a multicentre, open-label randomised controlled trial. Lancet (London, England) 382(9901):1341–1349CrossRef

56.

Goya M, de la Calle M, Pratcorona L, Merced C, Rodo C, Munoz B et al (2016) Cervical pessary to prevent preterm birth in women with twin gestation and sonographic short cervix: a multicenter randomized controlled trial (PECEP-Twins). Am J Obstet Gynecol 214(2):145–152CrossRefPubMed

57.

Fox NS, Gupta S, Lam-Rachlin J, Rebarber A, Klauser CK, Saltzman DH (2016) Cervical pessary and vaginal progesterone in twin pregnancies with a short cervix. Obstet Gynecol 127(4):625–630CrossRefPubMed

58.

Nicolaides KH, Syngelaki A, Poon LC, de Paco Matallana C, Plasencia W, Molina FS et al (2016) Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial. Am J Obstet Gynecol 214(1):3.e1–3.e9CrossRef

59.

Nicolaides KH (2016) Reply. Am J Obstet Gynecol 214(2):302CrossRefPubMed

60.

Liem SM, Schuit E, van Pampus MG, van Melick M, Monfrance M, Langenveld J et al (2016) Cervical pessaries to prevent preterm birth in women with a multiple pregnancy: a per-protocol analysis of a randomized clinical trial. Acta Obstet Gynecol Scand 95(4):444–451CrossRefPubMed

61.

van’t Hooft J, van der Lee JH, Opmeer BC, van Wassenaer-Leemhuis AG, van Baar AL, Bekedam DJ et al (2018) Pessary for prevention of preterm birth in twin pregnancy with short cervix: 3-year follow-up study. Ultrasound Obstet Gynecol 51(5):621–628CrossRef

62.

Papiernik-Berkhauer E (1970) Etude en double aveugle d’un medicament prevenant la survenue prematur´ee de l’accouchement chez des femmes ‘a risque eleve’ d’accouchement premature. Edition Schering IV(3):65–68

63.

Keirse MJ (1990) Progestogen administration in pregnancy may prevent preterm delivery. Br J Obstet Gynaecol 97(2):149–154CrossRefPubMed

64.

Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH et al (2003) Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 348(24):2379–2385CrossRefPubMed

65.

Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH (2007) Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 357(5):462–469CrossRefPubMed

66.

Romero R, Stanczyk FZ (2013) Progesterone is not the same as 17alpha-hydroxyprogesterone caproate: implications for obstetrical practice. Am J Obstet Gynecol 208(6):421–426CrossRefPubMed

67.

Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M et al (2011) Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 38(1):18–31CrossRefPubMedPubMedCentral

68.

FDA (2012) Background document for meeting of advisory committee for reproductive health drugs. Research Cfdea, ed White paper, confidential FDA

69.

Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S et al (2016) Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 387(10033):2106–2116CrossRefPubMedPubMedCentral

70.

Romero R, Conde-Agudelo A, Da Fonseca E, O’Brien JM, Cetingoz E, Creasy GW et al (2018) Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data. Am J Obstet Gynecol 218(2):161–180CrossRefPubMed

71.

Waters TP, Schultz BA, Mercer BM, Catalano PM (2009) Effect of 17alpha-hydroxyprogesterone caproate on glucose intolerance in pregnancy. Obstet Gynecol 114(1):45–49CrossRefPubMed

72.

Rebarber A, Istwan NB, Russo-Stieglitz K, Cleary-Goldman J, Rhea DJ, Stanziano GJ et al (2007) Increased incidence of gestational diabetes in women receiving prophylactic 17alpha-hydroxyprogesterone caproate for prevention of recurrent preterm delivery. Diabetes Care 30(9):2277–2280CrossRefPubMed

73.

Gyamfi C, Horton AL, Momirova V, Rouse DJ, Caritis SN, Peaceman AM et al (2009) The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies. Am J Obstet Gynecol 201(4):392e1-5CrossRef

74.

Prior M, Hibberd R, Asemota N, Thornton JG (2017) Inadvertent P-hacking among trials and systematic reviews of the effect of progestogens in pregnancy? A systematic review and meta-analysis. BJOG Int J Obstet Gynaecol 124(7):1008–1015CrossRef

75.

Norman JE, Mackenzie F, Owen P, Mactier H, Hanretty K, Cooper S et al (2009) Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis. Lancet 373(9680):2034–2040CrossRefPubMed

76.

Brizot ML, Hernandez W, Liao AW, Bittar RE, Francisco RPV, Krebs VLJ et al (2015) Vaginal progesterone for the prevention of preterm birth in twin gestations: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol 213(1):82e1–82e9CrossRef

77.

Rode L, Klein K, Nicolaides KH, Krampl-Bettelheim E, Tabor A, Group P (2011) Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 38(3):272–280CrossRef

78.

Serra V, Perales A, Meseguer J, Parrilla JJ, Lara C, Bellver J et al (2013) Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double-blind multicentre trial. BJOG Int J Obstet Gynaecol 120(1):50–57CrossRef

79.

Schuit E, Stock S, Rode L, Rouse DJ, Lim AC, Norman JE et al (2015) Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis. BJOG Int J Obstet Gynaecol 122(1):27–37CrossRef

80.

Dodd JM, Grivell RM, Ob CM, Dowswell T, Deussen AR (2017) Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database Syst Rev 10:CD012024PubMed

81.

Romero R, Conde-Agudelo A, El-Refaie W, Rode L, Brizot ML, Cetingoz E et al (2017) Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound Obstet Gynecol 49(3):303–314CrossRefPubMedPubMedCentral

82.

Boelig RC, Berghella V (2017) Current options for mechanical prevention of preterm birth. Semin Perinatol 41(8):452–460CrossRefPubMed

83.

Hargreave M, Jensen A, Nielsen TS, Colov EP, Andersen KK, Pinborg A et al (2015) Maternal use of fertility drugs and risk of cancer in children—a nationwide population-based cohort study in Denmark. Int J Cancer (Journal international du cancer) 136(8):1931–1939CrossRef

84.

Jorgensen AL, Alfirevic Z, Tudur Smith C, Williamson PR (2007) Cervical stitch (cerclage) for preventing pregnancy loss: individual patient data meta-analysis. BJOG Int J Obstet Gynaecol 114(12):1460–1476CrossRef

85.

Odibo AO, Berghella V, To MS, Rust OA, Althuisius SM, Nicolaides KH (2007) Shirodkar versus McDonald cerclage for the prevention of preterm birth in women with short cervical length. Am J Perinatol 24(1):55–60CrossRefPubMed

86.

Pergialiotis V, Vlachos DG, Prodromidou A, Perrea D, Gkioka E, Vlachos GD (2015) Double versus single cervical cerclage for the prevention of preterm births. J Maternal Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet 28(4):379–385

87.

Lotgering FK, Gaugler-Senden IP, Lotgering SF, Wallenburg HC (2006) Outcome after transabdominal cervicoisthmic cerclage. Obstet Gynecol 107(4):779–784CrossRefPubMed

88.

Alfirevic Z, Stampalija T, Roberts D, Jorgensen AL (2012) Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy. Cochrane Database Syst Rev 4:CD008991

89.

Rafael TJ, Berghella V, Alfirevic Z (2014) Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy. Cochrane Database Syst Rev 9:CD009166

90.

Saccone G, Rust O, Althuisius S, Roman A, Berghella V (2015) Cerclage for short cervix in twin pregnancies: systematic review and meta-analysis of randomized trials using individual patient-level data. Acta obstetricia et gynecologica Scandinavica 94(4):352–358CrossRefPubMed

91.

Gueant JL, Daval JL, Vert P, Nicolas JP (2012) Folates and fetal programming: role of epigenetics and epigenomics. Bulletin de l’Academie nationale de medecine 196(9):1829–1842CrossRefPubMed

92.

Alfirevic Z, Owen J, Carreras Moratonas E, Sharp AN, Szychowski JM, Goya M (2013) Vaginal progesterone, cerclage or cervical pessary for preventing preterm birth in asymptomatic singleton pregnant women with a history of preterm birth and a sonographic short cervix. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol 41(2):146–151CrossRef

93.

Conde-Agudelo A, Romero R, Da Fonseca E, O’Brien JM, Cetingoz E, Creasy GW et al (2018) Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis. Am J Obstet Gynecol 219(1):10–25CrossRefPubMedPubMedCentral

94.

Jarde A, Lutsiv O, Park CK, Beyene J, Dodd JM, Barrett J et al (2017) Effectiveness of progesterone, cerclage and pessary for preventing preterm birth in singleton pregnancies: a systematic review and network meta-analysis. BJOG Int J Obstet Gynaecol 124(8):1176–1189CrossRef

95.

Hezelgrave NL, Watson HA, Ridout A, Diab F, Seed PT, Chin-Smith E et al (2016) Rationale and design of SuPPoRT: a multi-centre randomised controlled trial to compare three treatments: cervical cerclage, cervical pessary and vaginal progesterone, for the prevention of preterm birth in women who develop a short cervix. BMC Pregnancy Childbirth 16(1):358CrossRefPubMedPubMedCentral

96.

Cruz-Melguizo S, San-Frutos L, Martinez-Payo C, Ruiz-Antoran B, Adiego-Burgos B, Campillos-Maza JM et al (2018) Cervical pessary compared with vaginal progesterone for preventing early preterm birth: a randomized controlled trial. Obstet Gynecol 132(4):907–915CrossRefPubMed

97.

Dang VQ, Nguyen LK, He YTN, Vu KN, Phan MTN, Pham TD, Vuong LTN, Le TQ, Mol BW (2018) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix < 38 mm: a randomized controlled trial. Am J Obstet Gynecol (suppl. 1):S603

98.

Dang VQ, Nguyen LK, He YT, Vu KN, Phan MT, Pham TD, et al eds (2018) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix <38 mm: a randomized controlled trial. SMFM 2018; Dallas

99.

Dang VQ (2019) Cervical pessary versus vaginal progesterone for the prevention of preterm birth in women with a twin pregnancy and a cervix <38 mm: a randomized controlled trial. Obstet Gynecol

100.

Boelig RC, Hecht N, Berghella V (2018) 698: Cervical length < 15 mm is the most important risk factor for early preterm birth in women with short cervix treated with vaginal progesterone. Am J Obstet Gynecol 218(1):S419–S420CrossRef

101.

Enakpene CA, DiGiovanni L, Jones TN, Marshalla M, Mastrogiannis D (2018) Della Torre M (2018) Cervical cerclage for singleton pregnant patients on vaginal progesterone with progressive cervical shortening. Am J Obstet Gynecol 219(4):397e1–397e10CrossRef

102.

Wolnicki GB, Wedel F, Mouzakiti N, Al Naimi A, Herzeg A, Bahlmann F et al (2019) Combined treatment of McDonald cerclage and Arabin-pessary: a chance in the prevention of spontaneous preterm birth? J Maternal Fetal Neonatal Med 23:1–9CrossRef

103.

Mourad M, Qin S, Ananth CV, Fu A, Yoshida K, Myers K et al (2017) Human cervical smooth muscle stretch increases pro-inflammatory cytocine secretion. Am J Obstet Gynecol 2017(Suppl 1):109

104.

Piso B, Zechmeister-Koss I, Winkler R (2014) Antenatal interventions to reduce preterm birth: an overview of cochrane systematic reviews. BMC Res Notes 7:265CrossRefPubMedPubMedCentral

105.

Carr DB, Clark AL, Kernek K, Spinnato JA (1999) Maintenance oral nifedipine for preterm labor: a randomized clinical trial. Am J Obstet Gynecol 181(4):822–827CrossRefPubMed

106.

Parry E, Roos C, Stone P, Hayward L, Mol BW, McCowan L (2014) The NIFTY study: a multicentre randomised double-blind placebo-controlled trial of nifedipine maintenance tocolysis in fetal fibronectin-positive women in threatened preterm labour. Aust N Z J obstet Gynaecol 54(3):231–236CrossRefPubMed

107.

Roos C, Spaanderman ME, Schuit E, Bloemenkamp KW, Bolte AC, Cornette J et al (2013) Effect of maintenance tocolysis with nifedipine in threatened preterm labor on perinatal outcomes: a randomized controlled trial. JAMA 309(1):41–47CrossRefPubMed

108.

Rozenberg P, Chauveaud A, Deruelle P, Capelle M, Winer N, Desbriere R et al (2012) Prevention of preterm delivery after successful tocolysis in preterm labor by 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Am J Obstet Gynecol 206(3):206e1–206e9CrossRef

109.

Palacio M, Ronzoni S, Sanchez-Ramos L, Murphy KE (2016) Progestogens as maintenance treatment in arrested preterm labor: a systematic review and meta-analysis. Obstet Gynecol 128(5):989–1000CrossRefPubMed

110.

Valenzuela GJ, Sanchez-Ramos L, Romero R, Silver HM, Koltun WD, Millar L et al (2000) Maintenance treatment of preterm labor with the oxytocin antagonist atosiban. The Atosiban PTL-098 Study Group. Am J Obstet Gynecol 182(5):1184–1190CrossRefPubMed

111.

Andrews WW, Goldenberg RL, Mercer B, Iams J, Meis P, Moawad A et al (2000) The preterm prediction study: association of second-trimester genitourinary chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 183(3):662–668CrossRefPubMed

112.

Goldenberg RL, Andrews WW, Goepfert AR, Faye-Petersen O, Cliver SP, Carlo WA et al (2008) The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants. American journal of obstetrics and gynecology. 198(1):43e1–43e5CrossRef

113.

Lamont RF, Sobel JD, Akins RA, Hassan SS, Chaiworapongsa T, Kusanovic JP et al (2011) The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG Int J Obstet Gynaecol 118(5):533–549CrossRef

114.

Sierra LJ, Brown AG, Barila GO, Anton L, Barnum CE, Shetye SS et al (2018) Colonization of the cervicovaginal space with Gardnerella vaginalis leads to local inflammation and cervical remodeling in pregnant mice. PLoS One 13(1):e0191524CrossRefPubMedPubMedCentral

115.

Leitich H, Brunbauer M, Bodner-Adler B, Kaider A, Egarter C, Husslein P (2003) Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. Am J Obstet Gynecol 188(3):752–758CrossRefPubMed

116.

Simcox R, Sin WT, Seed PT, Briley A, Shennan AH (2007) Prophylactic antibiotics for the prevention of preterm birth in women at risk: a meta-analysis. Aust N Z J Obstet Gynaecol 47(5):368–377CrossRefPubMed

117.

Kenyon S, Pike K, Jones DR, Brocklehurst P, Marlow N, Salt A et al (2008) Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 372(9646):1319–1327CrossRefPubMed

118.

Boggess KA (2010) Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the periodontal Infections and Prematurity Study (PIPS). Am J Obstet Gynecol 202(2):101–102CrossRefPubMed

119.

Jeffcoat M, Parry S, Gerlach RW, Doyle MJ (2011) Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population. Am J Obstet Gynecol 205(4):382e1–382e6CrossRef

120.

Jiang H, Xiong X, Buekens P, Su Y, Qian X (2015) Use of mouth rinse during pregnancy to improve birth and neonatal outcomes: a randomized controlled trial. BMC Pregnancy Childbirth 15:311CrossRefPubMedPubMedCentral

121.

Sosa CG, Althabe F, Belizan JM, Bergel E (2015) Bed rest in singleton pregnancies for preventing preterm birth. Cochrane Database Syst Rev 3:CD003581

122.

Satterfield N, Newton ER, May LE (2016) Activity in pregnancy for patients with a history of preterm birth. Clin Med Insights Womens Health 9(Suppl 1):17–21PubMedPubMedCentral

123.

Saccone G, Berghella V, Venturella R, D’Alessandro P, Arduino B, Raffone A et al (2018) Effects of exercise during pregnancy in women with short cervix: secondary analysis from the Italian pessary trial in singletons. Eur J Obstet Gynecol Reprod Biol 229:132–136CrossRefPubMed

124.

Rasanathan K, Bennett S, Atkins V, Beschel R, Carrasquilla G, Charles J et al (2017) Governing multisectoral action for health in low- and middle-income countries. PLoS Med 14(4):e1002285CrossRefPubMedPubMedCentral

125.

Ruckert A, Labonte R (2014) The global financial crisis and health equity: early experiences from Canada. Glob Health 10:2CrossRef

126.

Manasyan A, Saleem S, Koso-Thomas M, Althabe F, Pasha O, Chomba E et al (2013) Assessment of obstetric and neonatal health services in developing country health facilities. Am J Perinatol 30(9):787–794CrossRefPubMedPubMedCentral

127.

Althabe F, Belizan JM, McClure E, Goldenberg RL, Buekens PM (2015) Antenatal corticosteroids for preterm births in resource-limited settings—authors’ reply. Lancet 385(9981):1945CrossRefPubMed

128.

Berrueta M, Hemingway-Foday J, Thorsten VR, Goldenberg RL, Carlo WA, Garces A et al (2016) Use of antenatal corticosteroids at health facilities and communities in low-and-middle income countries. Reprod Health 13(1):66CrossRefPubMedPubMedCentral

Title: Prevention of spontaneous preterm birth
Authors: George Daskalakis
Maria Goya
Vasilios Pergialiotis
Luis Cabero
Ioannis Kyvernitakis
Aris Antsaklis
Birgit Arabin
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Premature Birth
Progesterone
Published in: Archives of Gynecology and Obstetrics / Issue 5/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05095-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prevention of spontaneous preterm birth

Abstract

Background

Findings

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Findings

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