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01-02-2019 | Ultrasound | Images in Obstetrics and Gynecology

Reference ranges for ultrasound measurements of fetal kidneys in a cohort of low-risk pregnant women

Authors: Ricardo M. Barbosa, Renato T. Souza, Carla Silveira, Kleber C. Andrade, Cristiane M. Almeida, Ana G. Bortoleto, Paulo F. Oliveira, Jose G. Cecatti

Published in: Archives of Gynecology and Obstetrics | Issue 2/2019

Abstract

Purpose

Alterations in renal dimensions may be an early manifestation of deviation from normality, with possible repercussions beyond intrauterine life. The objective of this study was to establish reference curves for fetal kidney dimensions and volume from 14 to 40 weeks of gestation.

Methods

This is a prospective longitudinal study of 115 Brazilian participants in the “WHO multicentre study for the development of growth standards from fetal life to childhood: the fetal component”. Pregnant women with clinical and sociodemographic characteristics allowing the full potential fetal growth were followed up from the first trimester until delivery. These women underwent serial sonographic evaluation of fetal kidneys. The longitudinal, anteroposterior and transverse diameters of both fetal kidneys were measured, in addition to calculation of kidney volume. By quantile regression analysis, reference curves of renal measurements related to gestational age were built.

Results

Standard normal sonographic values of renal biometry were defined during pregnancy. Reference values for the 10th, 50th and 90th centiles of different fetal kidney measurements (longitudinal, anteroposterior, transverse and volume) from the 14th to the 40th week of gestation were fitted.

Conclusion

The reference curves presented should be of the utmost importance for screening and diagnosis of alterations in renal development during the intrauterine period.

Policiano C, Djokovic D, Carvalho R et al (2015) Ultrasound antenatal detection of urinary tract anomalies in the last decade: outcome and prognosis. J Matern Fetal Neonatal Med 28(8):959–963. https://doi.org/10.3109/14767058.2014.939065 CrossRefPubMed

Devriendt A, Cassart M, Massez A et al (2013) Fetal kidneys: additional sonographic criteria of normal development. Prenat Diagn 33(13):1248–1252. https://doi.org/10.1002/pd.4240 CrossRefPubMed

Dias T, Sairam S, Kumarasiri S (2014) Ultrasound diagnosis of fetal renal abnormalities. Best Pract Res Clin Obstet Gynaecol 28(3):403–415CrossRef

Konje JC, Abrams KR, Bell SC et al (2002) Determination of gestational age after the 24th week of gestation from fetal kidney length measurements. Ultrasound Obstet Gynecol 19(6):592–597CrossRef

Ugur MG, Mustafa A, Ozcan HC et al (2016) Fetal kidney length as a useful adjunct parameter for better determination of gestational age. Saudi Med J 37(5):533–537CrossRef

Kaul I, Menia V, Anand AK et al (2012) Role of fetal kidney length in estimation of gestational age. JK Sci J 14(2):65–69

Seilanian Toosi F, Rezaie-Delui H (2013) Evaluation of the normal fetal kidney length and its correlation with gestational age. Acta Med Iran 51(5):303–306PubMed

Gupta DP, Gupta HP, Zaidi Z et al (2013) Accuracy in estimation of gestational age in third trimester by fetal kidney length in indian women. IJCP 24(5):459–463

Kumar K, Lalwani R, Babu R et al (2013) Ultrasonographic estimation of fetal gestational age by fetal kidney length. J Anat Soc India 62(1):33–36CrossRef

10.

Shivalingaiah N, Sowmya K, Ananya R et al (2017) Fetal kidney length as a parameter for determination of gestational age in pregnancy. Int J Reprod Contracept Obstet Gynecol 3(2):424–427

11.

Konje JC, Okaro CI, Bell SC et al (1997) A cross-sectional study of changes in fetal renal size with gestation in appropriate- and small-for-gestational-age fetuses. Ultrasound Obstet Gynecol 10(1):22–26CrossRef

12.

Konje JC, Bell SC, Morton JJ et al (1996) Human fetal kidney morphometry during gestation and the relationship between weight, kidney morphometry and plasma active renin concentration at birth. Clin Sci Lond 91(2):169–175CrossRef

13.

Chang CH, Tsai PY, Yu CH et al (2008) Predicting fetal growth restriction with renal volume using 3-D ultrasound: efficacy evaluation. Ultrasound Med Biol 34(4):533–537CrossRef

14.

Saha K, Shahida SM, Chowdhury NI et al (2014) Relationship between estimated foetal weight and renal volume in intra uterine growth retarded foetus in Bangladeshi women. Mymensingh Med J 23(4):752–757PubMed

15.

Verburg BO, Geelhoed JJ, Steegers EA et al (2007) Fetal kidney volume and its association with growth and blood flow in fetal life: the generation R study. Kidney Int 72(6):754–761CrossRef

16.

Singh RR, Denton KM (2015) Role of the kidney in the fetal programming of adult cardiovascular disease: an update. Curr Opin Pharmacol 21:53–59CrossRef

17.

Aulbert W, Kemper MJ (2016) Severe antenatally diagnosed renal disorders: background, prognosis and practical approach. Pediatr Nephrol 31(4):563–574CrossRef

18.

Spiro JE, Konrad M, Rieger-Fackeldey E et al (2015) Renal oligo- and anhydramnios: cause, course and outcome—a single-center study. Arch Gynecol Obstet 292(2):327–336CrossRef

19.

Bertagnoli L, Lalatta F, Gallicchio R et al (1983) Quantitative characterization of the growth of the fetal kidney. J Clin Ultrasound 11(7):349–356CrossRef

20.

Jeanty P, Dramaix-Wilmet M, Elkhazen N et al (1982) Measurements of fetal kidney growth on ultrasound. Radiology 144(1):159–162CrossRef

21.

Lawson TL, Foley WD, Berland LL et al (1981) Ultrasonic evaluation of fetal kidneys. Radiology 138(1):153–156CrossRef

22.

Cohen HL, Cooper J, Eisenberg P et al (1991) Normal length of fetal kidneys: sonographic study in 397 obstetric patients. AJR Am J Roentgenol 157(3):545–548CrossRef

23.

van Vuuren SH, Damen-Elias HA, Stigter RH et al (2012) Size and volume charts of fetal kidney, renal pelvis and adrenal gland. Ultrasound Obstet Gynecol 40(6):659–664CrossRef

24.

Chitty LS, Altman DG (2003) Charts of fetal size: kidney and renal pelvis measurements. Prenat Diagn 23(11):891–897CrossRef

25.

Geelhoed JJ, Taal HR, Steegers EA et al (2010) Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Pediatr Nephrol 25(2):289–298CrossRef

26.

Merialdi M, Widmer M, Gülmezoglu AM et al (2014) WHO multicentre study for the development of growth standards from fetal life to childhood: the fetal component. BMC Pregnancy Childbirth 14:157CrossRef

27.

Wei Y, Pere A, Koenker R et al (2006) Quantile regression methods for growth charts. Stat Med 25(8):1369–1382CrossRef

Title: Reference ranges for ultrasound measurements of fetal kidneys in a cohort of low-risk pregnant women
Authors: Ricardo M. Barbosa
Renato T. Souza
Carla Silveira
Kleber C. Andrade
Cristiane M. Almeida
Ana G. Bortoleto
Paulo F. Oliveira
Jose G. Cecatti
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Keywords: Ultrasound
Ultrasound
Published in: Archives of Gynecology and Obstetrics / Issue 2/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-5032-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Reference ranges for ultrasound measurements of fetal kidneys in a cohort of low-risk pregnant women

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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