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Archives of Gynecology and Obstetrics

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01-02-2019 | General Gynecology

Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility

Authors: Mohsen Rokni, Saeedeh Salimi, Tayebeh Sohrabi, Somaye Asghari, Batool Teimoori, Mohsen Saravani

Published in: Archives of Gynecology and Obstetrics | Issue 2/2019

Abstract

Background

Preeclampsia (PE) is one of the main causes of death among the pregnant women as well as newborns. Although the etiological cause of preeclampsia is not yet clear, a range of risk factors has been suggested. MicroRNAs (like miRNA-152) are small non-coding molecules that play a role in a wide spectrum of biological processes, such as cell proliferation and angiogenesis. This study aimed to investigate the possible relationship of miRNA-152 rs12940701 polymorphism and the risk of preeclampsia among the pregnant women as compared with the control group.

Methods

Genotyping of miRNA-152 rs12940701 polymorphism was performed using blood and placenta samples of 223 preeclampsia women and 229 normotensive pregnant women by a polymerase chain reaction-restriction fragment length polymorphism method.

Results

The results obtained from maternal blood showed an increase in T alleles for PE women, that there was no significant difference between the PE and control group (OR = 1.7, P = 0.19). In addition, no significant difference was found in the TT genotype between the two groups (11.6% vs. 7%, OR = 1.4, P = 0.3). Similarly, the results obtained from placental samples were identical.

Conclusions

A lack of relationship between the polymorphism of miRNA-152 rs12940701 gene and preeclampsia development has been shown.

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Title: Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility
Authors: Mohsen Rokni
Saeedeh Salimi
Tayebeh Sohrabi
Somaye Asghari
Batool Teimoori
Mohsen Saravani
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4979-y

At a glance: The STEP trials

Springer Medicine

Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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