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01-06-2017 | Gynecologic Endocrinology and Reproductive Medicine

Gestational diabetes mellitus is a significant risk factor for long-term ophthalmic morbidity

Authors: Ofer Beharier, Ruslan Sergienko, Roy Kessous, Irit Szaingurten-Solodkin, Asnat Walfisch, Eden Shusterman, Erez Tsumi, Eyal Sheiner

Published in: Archives of Gynecology and Obstetrics | Issue 6/2017

Abstract

Purpose

To investigate whether patients with a history of gestational diabetes mellitus (GDM) have an increased risk for long-term ophthalmic morbidity.

Methods

Design a population-based study compared the incidence of long-term maternal ophthalmic morbidity in a cohort of women with and without a history of GDM. Setting Soroka University Medical Center. Participants: All singleton pregnancies of women who delivered between 1988 and 2013. Main outcome measure(s) Diagnosis of ophthalmic morbidity. Analyses A Kaplan–Meier survival curve was used to estimate cumulative incidence of ophthalmic morbidity. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HR) for ophthalmic morbidity.

Results

During the study period, 104,751 deliveries met the inclusion criteria; 9.4% (n = 9888) of which occurred in patients with a diagnosis of GDM during at least one of their pregnancies. Patients with GDM had a significantly higher incidence of ophthalmic morbidity such as glaucoma, diabetic retinopathy, and retinal detachment compared with controls (0.1 vs. 0.02%, p < 0.001; 0.2 vs. 0.04%, p < 0.001; 0.2 vs. 0.1%, p < 0.001, respectively). Patients with concurrent GDM and preeclampsia had a significantly higher incidence of total ophthalmic complications compared to patients with GDM only (1 vs. 0.6%, respectively, p < 0.001). Using Kaplan–Meier survival curve, patients with a previous diagnosis of GDM had significantly higher cumulative incidence of ophthalmic morbidity (p < 0.001, log-rank test). In the Cox proportional hazards model, a history of GDM remained independently associated with ophthalmic morbidity (adjusted HR 2.0; 95% CI 1.5–2.8; p < 0.001).

Conclusions

GDM is an independent risk factor for long-term maternal ophthalmic morbidity.

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Title: Gestational diabetes mellitus is a significant risk factor for long-term ophthalmic morbidity
Authors: Ofer Beharier
Ruslan Sergienko
Roy Kessous
Irit Szaingurten-Solodkin
Asnat Walfisch
Eden Shusterman
Erez Tsumi
Eyal Sheiner
Publication date: 01-06-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 6/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4362-4

At a glance: The STEP trials

Springer Medicine

Gestational diabetes mellitus is a significant risk factor for long-term ophthalmic morbidity

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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