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Archives of Gynecology and Obstetrics

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01-02-2017 | General Gynecology

Effect of elevated estradiol levels on the hCG administration day on IVF pregnancy and birth outcomes in the long GnRH-agonist protocol: analysis of 3393 cycles

Authors: Meimei Wang, Cuifang Hao, Hongchu Bao, Xin Huang, Zhenteng Liu, Wei Zhang, Fenghua Li

Published in: Archives of Gynecology and Obstetrics | Issue 2/2017

Abstract

Introduction

This retrospective study aimed to evaluate the association between elevated serum estradiol (E ₂) levels on the human chorionic gonadotrophin (hCG) administration day and in vitro fertilization (IVF) pregnancy and birth outcomes in the long GnRH-agonist protocol.

Methods

This study analyzed the data of 3393 infertile women who underwent initial fresh IVF. The patients were categorized into high and low E ₂ groups based on their serum E ₂ levels on the hCG day. Pregnancy and birth outcomes were compared.

Results

The implantation rate, clinical pregnancy rate, and live birth rate were all significantly higher in the high E ₂ group than in the low E ₂ group (p < 0.05). The good-quality embryo rate and abortion rate did not significantly differ between the two groups. There were no significant differences in the mode of delivery, gestational age, birth weight, and fetal gender between the two groups. Furthermore, there were no differences in the risk of preterm birth, low birth weight, and fetal malformation between the two groups in 860 single live births. Subgroup analysis of singleton pregnancies in the high E ₂ (E ₂ ≥ 3757 pg/mL) group revealed a significant increase in abortion rate in the age group of ≥37 years.

Conclusions

Elevated serum E ₂ levels associated with controlled ovarian stimulation did not increase the risks of preterm birth, low birth weight, and fetal malformation. High E ₂ on the hCG day had no detrimental effect on the implantation rate, clinical pregnancy rate, and live birth rate.

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Title: Effect of elevated estradiol levels on the hCG administration day on IVF pregnancy and birth outcomes in the long GnRH-agonist protocol: analysis of 3393 cycles
Authors: Meimei Wang
Cuifang Hao
Hongchu Bao
Xin Huang
Zhenteng Liu
Wei Zhang
Fenghua Li
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4242-3

Keynote webinar | Spotlight on sleep in brain health

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Effect of elevated estradiol levels on the hCG administration day on IVF pregnancy and birth outcomes in the long GnRH-agonist protocol: analysis of 3393 cycles

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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