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Published in: Archives of Gynecology and Obstetrics 4/2016

01-10-2016 | General Gynecology

Risk factors for ectopic pregnancy in the Taiwanese population: a retrospective observational study

Authors: Alan Hwang, Leslie Chou, M. M. Islam, Yu-Chuan Li, Shabbir Syed-Abdul

Published in: Archives of Gynecology and Obstetrics | Issue 4/2016

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Abstract

Objective

The aim of this study is to explore the risk factors for ectopic pregnancy (EP) in the Taiwanese population and to identify any unknown risk factors for EP that could assist awareness and diagnosis.

Methods

This retrospective case–control study utilizes Taiwan’s National Health Insurance Research Database (NHIRD). Analysis was conducted with a one million sample database representative of the country’s population. The case group comprised of 6637 individuals in the database that coded for EP using the ICD-9 classification system from January 2003 to December 2011. The control group comprised of 13,270 females matched by age that were never diagnosed with EP during the study period.

Results

This study provides an analysis of the risk factors of EP utilizing NHIRD. Among the 6637 people diagnosed with EP, logistic regression with age adjustment showed that the highest risk factor was endometriosis (OR = 8.84, CI 5.13–15.23), followed by polycystic ovary (OR = 7.74, CI 3.37–17.79) and benign neoplasm of the ovary (6.01, CI 2.18–16.54). All odds ratios were determined to be statistically significant at p < 0.001.

Conclusion

This study has identified the diagnosis of endometriosis and polycystic ovaries as the two largest risk factors for EP in Taiwan, and has also newly identified benign neoplasm of ovary and uterine leiomyoma as risk factors for EP.
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Metadata
Title
Risk factors for ectopic pregnancy in the Taiwanese population: a retrospective observational study
Authors
Alan Hwang
Leslie Chou
M. M. Islam
Yu-Chuan Li
Shabbir Syed-Abdul
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-016-4117-7

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