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Published in: Archives of Gynecology and Obstetrics 4/2013

01-10-2013 | Reproductive Medicine

Ectopic pregnancy: a review

Authors: Poonam Rana, Imran Kazmi, Rajbala Singh, Muhammad Afzal, Fahad A. Al-Abbasi, Ali Aseeri, Rajbir Singh, Ruqaiyah Khan, Firoz Anwar

Published in: Archives of Gynecology and Obstetrics | Issue 4/2013

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Abstract

Purpose

Ectopic pregnancy (EP) presents a major health problem for women of child-bearing age. EP refers to the pregnancy occurring outside the uterine cavity that constitutes 1.2–1.4 % of all reported pregnancies. All identified risk factors are maternal: pelvic inflammatory disease, Chlamydia trachomatis infection, smoking, tubal surgery, induced conception cycle, and endometriosis. These developments have provided the atmosphere for trials using methotrexate as a non-surgical treatment for EP. The diagnosis measure of EP is serum human chorionic gonadotropin, urinary hCGRP/i-hCG, progesterone measurement, transvaginal ultrasound scan, computed tomography, vascular endothelial growth factor, CK, disintegrin and metalloprotease-12 and hysterosalpingography. The treatment option of EP involves surgical treatment by laparotomy or laparoscopy, medical treatment is usually systemic or through local route, or by expectant treatment.

Results

It was concluded that review data reflect a decrease in surgical treatment and not an actual decline in EP occurrence so that further new avenues are needed to explore early detection of the EP.
Literature
1.
go back to reference Kirk E, Bourne T (2011) Ectopic pregnancy. Obstet Gynecol Reprod Med 21:207–211 Kirk E, Bourne T (2011) Ectopic pregnancy. Obstet Gynecol Reprod Med 21:207–211
2.
go back to reference Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF (2006) WHO analysis of causes of maternal death: a systematic review. Lancet 367:1066–1074PubMedCrossRef Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF (2006) WHO analysis of causes of maternal death: a systematic review. Lancet 367:1066–1074PubMedCrossRef
4.
go back to reference Varma R, Gupta J (2009) Tubal ectopic pregnancy. Clin Evid 20:406 Varma R, Gupta J (2009) Tubal ectopic pregnancy. Clin Evid 20:406
5.
go back to reference Shaw JL, Dey SK, Critchley HO, Horne AW (2010) Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update 16:432–444PubMedCrossRef Shaw JL, Dey SK, Critchley HO, Horne AW (2010) Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update 16:432–444PubMedCrossRef
6.
go back to reference Sivalingam VN, Duncan WC, Kirk E, Shephard LA, Horne AW (2011) Diagnosis and management of ectopic pregnancy. J Fam Plann Reprod Health Care 37:231–240PubMedCrossRef Sivalingam VN, Duncan WC, Kirk E, Shephard LA, Horne AW (2011) Diagnosis and management of ectopic pregnancy. J Fam Plann Reprod Health Care 37:231–240PubMedCrossRef
7.
go back to reference Bouyer J, Coste J, Fernandez H (2002) Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod 17:3224–3230PubMedCrossRef Bouyer J, Coste J, Fernandez H (2002) Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod 17:3224–3230PubMedCrossRef
8.
go back to reference Musa J (2009) Ectopic pregnancy in Jos Northern Nigeria: prevalence and impact on subsequent fertility. Niger J Med 18:8–35 Musa J (2009) Ectopic pregnancy in Jos Northern Nigeria: prevalence and impact on subsequent fertility. Niger J Med 18:8–35
10.
go back to reference Stovall TG, Ling FW, Carson SA, Buster JE (1990) Nonsurgical diagnosis and treatment of tubal pregnancy. Fertil Steril 54:537–538PubMed Stovall TG, Ling FW, Carson SA, Buster JE (1990) Nonsurgical diagnosis and treatment of tubal pregnancy. Fertil Steril 54:537–538PubMed
11.
13.
go back to reference Dickens BM, Faundes A, Cook RJ (2003) Ectopic pregnancy and emergency care: ethical and legal issues. Int J Gynecol Obstet 82:121–126CrossRef Dickens BM, Faundes A, Cook RJ (2003) Ectopic pregnancy and emergency care: ethical and legal issues. Int J Gynecol Obstet 82:121–126CrossRef
14.
go back to reference Gamzu R, Almog B, Levin Y, Avni A, Jaffa A, Lessing J (2002) Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations. Fertil Steril 77:761–765PubMedCrossRef Gamzu R, Almog B, Levin Y, Avni A, Jaffa A, Lessing J (2002) Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations. Fertil Steril 77:761–765PubMedCrossRef
15.
go back to reference Valley VT, Mateer JR, Aiman EJ (1998) Serum progesterone endovaginal sonography by emergency physicians in the evaluation of ectopic pregnancy. Acad Emerg Med 5:309–313PubMedCrossRef Valley VT, Mateer JR, Aiman EJ (1998) Serum progesterone endovaginal sonography by emergency physicians in the evaluation of ectopic pregnancy. Acad Emerg Med 5:309–313PubMedCrossRef
16.
go back to reference Marion LL, Meeks GR (2012) Ectopic pregnancy: history, incidence, epidemiology, and risk factors. Clin Obstet Gynecol 55:376–386PubMedCrossRef Marion LL, Meeks GR (2012) Ectopic pregnancy: history, incidence, epidemiology, and risk factors. Clin Obstet Gynecol 55:376–386PubMedCrossRef
17.
go back to reference Wedderburn CJ, Warner P, Graham B, Duncan WC, Critchley HO, Horne AW (2010) Economic evaluation of diagnosing and excluding ectopic pregnancy. Hum Reprod 25:328–333PubMedCrossRef Wedderburn CJ, Warner P, Graham B, Duncan WC, Critchley HO, Horne AW (2010) Economic evaluation of diagnosing and excluding ectopic pregnancy. Hum Reprod 25:328–333PubMedCrossRef
18.
go back to reference Bakken IJ, Skjeldestad FE (2003) Incidence and treatment of extrauterine pregnancies in Norway 1990–2001. Tidsskr Nor Laegeforen 123:3016–3020PubMed Bakken IJ, Skjeldestad FE (2003) Incidence and treatment of extrauterine pregnancies in Norway 1990–2001. Tidsskr Nor Laegeforen 123:3016–3020PubMed
19.
go back to reference Boufous S, Quartararo M, Mohsin M (2001) Trends in the incidence of ectopic pregnancy in New South Wales between 1990–1998. Aust N Z J Obstet Gynaecol 41:436–438PubMedCrossRef Boufous S, Quartararo M, Mohsin M (2001) Trends in the incidence of ectopic pregnancy in New South Wales between 1990–1998. Aust N Z J Obstet Gynaecol 41:436–438PubMedCrossRef
20.
go back to reference Lewis G (2007) Saving mothers’ lives: reviewing maternal deaths to make motherhood safer 2003–2005. CEMACH, London Lewis G (2007) Saving mothers’ lives: reviewing maternal deaths to make motherhood safer 2003–2005. CEMACH, London
21.
go back to reference Al-Turki HA (2013) Trends in ectopic pregnancies in Eastern Saudi Arabia. ISRN Obstet Gynecol, article ID 975251 Al-Turki HA (2013) Trends in ectopic pregnancies in Eastern Saudi Arabia. ISRN Obstet Gynecol, article ID 975251
22.
go back to reference Calderon JL, Shaheen M, Pan D, Teklehaimenot S, Robinson PL, Baker RS (2005) Multi-cultural surveillance for ectopic pregnancy: California 1991–2000. Ethn Dis 15:S4–S5 Calderon JL, Shaheen M, Pan D, Teklehaimenot S, Robinson PL, Baker RS (2005) Multi-cultural surveillance for ectopic pregnancy: California 1991–2000. Ethn Dis 15:S4–S5
23.
go back to reference Sewell CA, Cundiff GW (2002) Trends for inpatient treatment of tubal pregnancy in Maryland. Am J Obstet Gynecol 186:404–408PubMedCrossRef Sewell CA, Cundiff GW (2002) Trends for inpatient treatment of tubal pregnancy in Maryland. Am J Obstet Gynecol 186:404–408PubMedCrossRef
24.
go back to reference Condous G (2004) The management of early pregnancy complications. Best Pract Res Clin Obstet Gynaecol 18:37–57PubMedCrossRef Condous G (2004) The management of early pregnancy complications. Best Pract Res Clin Obstet Gynaecol 18:37–57PubMedCrossRef
25.
go back to reference Ackerman TE, Levi CS, Dashefsky SM (1993) Interstitial line: sonographic finding in interstitial (cornual) ectopic pregnancy. Radiology 189:83–87PubMed Ackerman TE, Levi CS, Dashefsky SM (1993) Interstitial line: sonographic finding in interstitial (cornual) ectopic pregnancy. Radiology 189:83–87PubMed
26.
go back to reference Kirk E, Daemen A, Papageorghiou AT (2008) Why are some ectopic pregnancies characterized as pregnancies of unknown location at the initial transvaginal ultrasound examination? Acta Obstet Gynecol Scand 87:1150–1154PubMedCrossRef Kirk E, Daemen A, Papageorghiou AT (2008) Why are some ectopic pregnancies characterized as pregnancies of unknown location at the initial transvaginal ultrasound examination? Acta Obstet Gynecol Scand 87:1150–1154PubMedCrossRef
27.
go back to reference Webb EM, Green GE, Scoutt LM (2004) Adnexal mass with pelvic pain. Radiol Clin North Am 42:329–348PubMedCrossRef Webb EM, Green GE, Scoutt LM (2004) Adnexal mass with pelvic pain. Radiol Clin North Am 42:329–348PubMedCrossRef
28.
go back to reference Ushakov FB, Elchalal U, Aceman PJ (1996) Cervical pregnancy: past and future. Obstet Gynecol Surv 52:45–59CrossRef Ushakov FB, Elchalal U, Aceman PJ (1996) Cervical pregnancy: past and future. Obstet Gynecol Surv 52:45–59CrossRef
29.
go back to reference Leeman LM, Wendland CL (2000) Cervical ectopic pregnancy: diagnosis with endocervical ultrasound examination and successful treatment with methotrexate. Arch Fam Med 9:72–77PubMedCrossRef Leeman LM, Wendland CL (2000) Cervical ectopic pregnancy: diagnosis with endocervical ultrasound examination and successful treatment with methotrexate. Arch Fam Med 9:72–77PubMedCrossRef
30.
go back to reference Jurkovic D, Marvelos D (2007) Catch me if you can: ultrasound diagnosis of ectopic pregnancy. Ultrasound Obstet Gynecol 30:1–7PubMedCrossRef Jurkovic D, Marvelos D (2007) Catch me if you can: ultrasound diagnosis of ectopic pregnancy. Ultrasound Obstet Gynecol 30:1–7PubMedCrossRef
32.
go back to reference Odejinmi F, Rizzuto MI, MacRae R, Olowu O, Hussain M (2009) Diagnosis and laparoscopic management of 12 consecutive cases of ovarian pregnancy and review of literature. J Minim Invasive Gynecol 16:354–359PubMedCrossRef Odejinmi F, Rizzuto MI, MacRae R, Olowu O, Hussain M (2009) Diagnosis and laparoscopic management of 12 consecutive cases of ovarian pregnancy and review of literature. J Minim Invasive Gynecol 16:354–359PubMedCrossRef
33.
go back to reference Gon S (2011) Two cases of primary ectopic ovarian pregnancy. OJHAS 10(1):26 Gon S (2011) Two cases of primary ectopic ovarian pregnancy. OJHAS 10(1):26
34.
go back to reference Plotti F, Di GA, Oliva C, Battaglia FG (2008) Plotti, “Bilateral ovarian pregnancy after intrauterine insemination and controlled ovarian stimulation”. Fertil Steril 90(5):2015.e3–2015.e5CrossRef Plotti F, Di GA, Oliva C, Battaglia FG (2008) Plotti, “Bilateral ovarian pregnancy after intrauterine insemination and controlled ovarian stimulation”. Fertil Steril 90(5):2015.e3–2015.e5CrossRef
35.
go back to reference Panda S, Darlong LM, Singh S, Borah T (2009) Case report of a primary ovarian pregnancy in a primigravida. J Hum Reprod Sci 2:90–92PubMedCrossRef Panda S, Darlong LM, Singh S, Borah T (2009) Case report of a primary ovarian pregnancy in a primigravida. J Hum Reprod Sci 2:90–92PubMedCrossRef
36.
go back to reference Odejinmi F, Sangrithi M, Olowu O (2011) Operative laparoscopy as the mainstay method in management of hemodynamically unstable patients with ectopic pregnancy. J Minim Invasive Gynecol 18:179–183PubMedCrossRef Odejinmi F, Sangrithi M, Olowu O (2011) Operative laparoscopy as the mainstay method in management of hemodynamically unstable patients with ectopic pregnancy. J Minim Invasive Gynecol 18:179–183PubMedCrossRef
37.
go back to reference Seow K, Hang L, Lin Y (2004) Cesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol 23:247–253PubMedCrossRef Seow K, Hang L, Lin Y (2004) Cesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol 23:247–253PubMedCrossRef
38.
go back to reference Rotas MA, Haberman S, Levgur M (2006) Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol 107:1373–1381PubMedCrossRef Rotas MA, Haberman S, Levgur M (2006) Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol 107:1373–1381PubMedCrossRef
39.
go back to reference Jin H, Shou J, Yu Y (2004) Intramural pregnancy, a report of two cases. J Reprod Med 49:569–572PubMed Jin H, Shou J, Yu Y (2004) Intramural pregnancy, a report of two cases. J Reprod Med 49:569–572PubMed
40.
go back to reference Graesslin O, Dedecker F, Quereux C (2005) Conservative treatment of ectopic pregnancy in a cesarean scar. Obstet Gynecol 105:869–871PubMedCrossRef Graesslin O, Dedecker F, Quereux C (2005) Conservative treatment of ectopic pregnancy in a cesarean scar. Obstet Gynecol 105:869–871PubMedCrossRef
41.
go back to reference Shufaro Y, Nadjari M (2001) Implantation of a gestational sac in a cesarean section scar. Fertil Steril 75:1217PubMedCrossRef Shufaro Y, Nadjari M (2001) Implantation of a gestational sac in a cesarean section scar. Fertil Steril 75:1217PubMedCrossRef
42.
go back to reference Katz DL, Barrett JP, Sanfilippo JS, Badway DM (2003) Combined hysteroscopy and laparoscopy in the treatment of interstitial pregnancy. Am J Obstet Gynecol 188:1113–1114PubMedCrossRef Katz DL, Barrett JP, Sanfilippo JS, Badway DM (2003) Combined hysteroscopy and laparoscopy in the treatment of interstitial pregnancy. Am J Obstet Gynecol 188:1113–1114PubMedCrossRef
43.
go back to reference Nahum GG (2002) Rudimentary uterine horn pregnancy. The 20th century worldwide experience of 588 cases. J Reprod Med 47:151–163PubMed Nahum GG (2002) Rudimentary uterine horn pregnancy. The 20th century worldwide experience of 588 cases. J Reprod Med 47:151–163PubMed
44.
go back to reference Malinowski A, Bates SK (2006) Semantics and pitfalls in the diagnosis of cornual/interstitial pregnancy. Fertil Steril 86:e11–e14PubMedCrossRef Malinowski A, Bates SK (2006) Semantics and pitfalls in the diagnosis of cornual/interstitial pregnancy. Fertil Steril 86:e11–e14PubMedCrossRef
45.
go back to reference Kun WM, Tung WK (2001) On the look out for a rarity—interstitial/cornual pregnancy. Eur J Emerg Med 8:147–150PubMedCrossRef Kun WM, Tung WK (2001) On the look out for a rarity—interstitial/cornual pregnancy. Eur J Emerg Med 8:147–150PubMedCrossRef
46.
go back to reference Moon HS, Choi YJ, Park VH, Kim SG (2000) New simple endoscopic operations for interstitial pregnancies. Am J Obstet Gynecol 152:114–121CrossRef Moon HS, Choi YJ, Park VH, Kim SG (2000) New simple endoscopic operations for interstitial pregnancies. Am J Obstet Gynecol 152:114–121CrossRef
47.
go back to reference Sonmezer M, Taskin S, Atabekoglu C (2006) Laparoscopic management of rudimentary uterine horn pregnancy: case report and literature review. JSLS 10:396–399PubMed Sonmezer M, Taskin S, Atabekoglu C (2006) Laparoscopic management of rudimentary uterine horn pregnancy: case report and literature review. JSLS 10:396–399PubMed
48.
go back to reference Panayotidis C, Abdel FM, Leggott M (2004) Rupture of rudimentary uterine horn of a unicornuate uterus at 15 weeks’gestation. J Obstet Gynecol 24:323–324CrossRef Panayotidis C, Abdel FM, Leggott M (2004) Rupture of rudimentary uterine horn of a unicornuate uterus at 15 weeks’gestation. J Obstet Gynecol 24:323–324CrossRef
49.
go back to reference Yildizhan R, Kurdoglu M, Kolusari A, Erten R (2008) Primary omental pregnancy. Saudi Med J 29:606–609PubMed Yildizhan R, Kurdoglu M, Kolusari A, Erten R (2008) Primary omental pregnancy. Saudi Med J 29:606–609PubMed
50.
go back to reference Sarwat A, Nadia A (2011) Abdominal pregnancy: a diagnostic dilemma. Prof Med J 18:479–484 Sarwat A, Nadia A (2011) Abdominal pregnancy: a diagnostic dilemma. Prof Med J 18:479–484
51.
go back to reference Ayinde OA, Aimakhu CO, Adeyanju OA (2005) Abdominal pregnancy at the University College Hospital, Ibadan: a ten-year review. Afr J Reprod Health 9:123–127PubMedCrossRef Ayinde OA, Aimakhu CO, Adeyanju OA (2005) Abdominal pregnancy at the University College Hospital, Ibadan: a ten-year review. Afr J Reprod Health 9:123–127PubMedCrossRef
52.
go back to reference Oki T, Baba Y, Yoshinaga M (2008) Super-selective arterial embolization for uncontrolled bleeding in abdominal pregnancy. Obstet Gynecol 112:427–429PubMedCrossRef Oki T, Baba Y, Yoshinaga M (2008) Super-selective arterial embolization for uncontrolled bleeding in abdominal pregnancy. Obstet Gynecol 112:427–429PubMedCrossRef
53.
go back to reference Ludwig M (1999) Heterotopic pregnancy in a spontaneous cycle: do not forget about it. Eur J Obstet Gynecol Reprod Biol 87:91–103PubMedCrossRef Ludwig M (1999) Heterotopic pregnancy in a spontaneous cycle: do not forget about it. Eur J Obstet Gynecol Reprod Biol 87:91–103PubMedCrossRef
54.
go back to reference Rojansky N, Schenker JG (1996) Heterotopic pregnancy and assisted reproduction—an update. J Assist Reprod Genet 13:594–601PubMedCrossRef Rojansky N, Schenker JG (1996) Heterotopic pregnancy and assisted reproduction—an update. J Assist Reprod Genet 13:594–601PubMedCrossRef
55.
go back to reference Condous G, Okaro E, Bourne T (2003) The conservative management of early pregnancy complications: a review of the literature. Ultrasound Obstet Gynecol 22:420–430PubMedCrossRef Condous G, Okaro E, Bourne T (2003) The conservative management of early pregnancy complications: a review of the literature. Ultrasound Obstet Gynecol 22:420–430PubMedCrossRef
56.
go back to reference Glassner MJ, Aron E, Eskin BA (1990) Ovulation induction with clomiphene and the rise in heterotopic pregnancies: a report of two cases. J Reprod Med 35:175–178PubMed Glassner MJ, Aron E, Eskin BA (1990) Ovulation induction with clomiphene and the rise in heterotopic pregnancies: a report of two cases. J Reprod Med 35:175–178PubMed
57.
go back to reference Madhuri P (2012) Ectopic pregnancy after infertility treatment. J Hum Reprod Sci 5:154–165CrossRef Madhuri P (2012) Ectopic pregnancy after infertility treatment. J Hum Reprod Sci 5:154–165CrossRef
58.
go back to reference Onan MA, Turp AB, Saltik A, Akyurek N, Taskiran C, Himmetoglu O (2005) Primary omental pregnancy: case report. Hum Reprod 20:807–809PubMedCrossRef Onan MA, Turp AB, Saltik A, Akyurek N, Taskiran C, Himmetoglu O (2005) Primary omental pregnancy: case report. Hum Reprod 20:807–809PubMedCrossRef
59.
go back to reference Bakken IJ (2008) Chlamydia trachomatis and ectopic pregnancy: recent epidemiological findings. Curr Opin Infect Dis 21:77–82PubMedCrossRef Bakken IJ (2008) Chlamydia trachomatis and ectopic pregnancy: recent epidemiological findings. Curr Opin Infect Dis 21:77–82PubMedCrossRef
60.
go back to reference Bjartling C, Osser S, Persson K (2007) Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the fallopian tubes of patients with ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol 134:95–100PubMedCrossRef Bjartling C, Osser S, Persson K (2007) Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the fallopian tubes of patients with ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol 134:95–100PubMedCrossRef
61.
go back to reference Low N, Egger M, Sterne JA, Harbord RM, Ibrahim F, Lindblom B, Herrmann B (2006) Incidence of severe reproductive tract complications associated with diagnosed genital chlamydial infection: the Uppsala Women’s Cohort Study. Sex Transm Infect 82:212–218PubMedCrossRef Low N, Egger M, Sterne JA, Harbord RM, Ibrahim F, Lindblom B, Herrmann B (2006) Incidence of severe reproductive tract complications associated with diagnosed genital chlamydial infection: the Uppsala Women’s Cohort Study. Sex Transm Infect 82:212–218PubMedCrossRef
62.
go back to reference Van Valkengoed IG, Morré SA, van den Brule AJ, Meijer CJ, Bouter LM, Boeke AJ (2004) Overestimation of complication rates in evaluations of Chlamydia trachomatis screening programmes—implications for cost-effectiveness analyses. Int J Epidemiol 33:416–425PubMedCrossRef Van Valkengoed IG, Morré SA, van den Brule AJ, Meijer CJ, Bouter LM, Boeke AJ (2004) Overestimation of complication rates in evaluations of Chlamydia trachomatis screening programmes—implications for cost-effectiveness analyses. Int J Epidemiol 33:416–425PubMedCrossRef
63.
go back to reference Ault KA, Statland BD, King MM, Dozier DI, Joachims ML, Gunter J (1998) Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility. Infect Dis Obstet Gynecol 6:163–167PubMed Ault KA, Statland BD, King MM, Dozier DI, Joachims ML, Gunter J (1998) Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility. Infect Dis Obstet Gynecol 6:163–167PubMed
64.
go back to reference Rank RG, Dascher C, Bowlin AK, Bavoil PM (1995) Systemic immunization with Hsp60 alters the development of chlamydial ocular disease. Invest Ophthalmol Vis Sci 36:1344–1351PubMed Rank RG, Dascher C, Bowlin AK, Bavoil PM (1995) Systemic immunization with Hsp60 alters the development of chlamydial ocular disease. Invest Ophthalmol Vis Sci 36:1344–1351PubMed
65.
go back to reference Shaw JL, Oliver E, Lee KF (2010) Cotinine exposure increases fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. Am J Pathol 177:2509–2515PubMedCrossRef Shaw JL, Oliver E, Lee KF (2010) Cotinine exposure increases fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. Am J Pathol 177:2509–2515PubMedCrossRef
66.
go back to reference Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M (2000) Maternal age and fetal loss: population based register linkage study. BMJ 320(7251):1708–1712PubMedCrossRef Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M (2000) Maternal age and fetal loss: population based register linkage study. BMJ 320(7251):1708–1712PubMedCrossRef
67.
go back to reference Goddijn M, van der Veen F, Schuring Blom GH, Ankum WM, Leschot NJ (1996) Cytogenetic characteristics of ectopic pregnancy. Hum Reprod 11:2769–2771PubMedCrossRef Goddijn M, van der Veen F, Schuring Blom GH, Ankum WM, Leschot NJ (1996) Cytogenetic characteristics of ectopic pregnancy. Hum Reprod 11:2769–2771PubMedCrossRef
68.
go back to reference Bouyer J, Coste J, Shojaei T (2003) Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population-based study in France. Am J Epidemiol 157:185–194PubMedCrossRef Bouyer J, Coste J, Shojaei T (2003) Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population-based study in France. Am J Epidemiol 157:185–194PubMedCrossRef
69.
go back to reference Knoll M, Shaoulian R, Magers T, Talbot P (1995) Ciliary beat frequency of hamster oviducts is decreased in vitro by exposure to solutions of mainstream and sidestream cigarette smoke. Biol Reprod 53:29–37PubMedCrossRef Knoll M, Shaoulian R, Magers T, Talbot P (1995) Ciliary beat frequency of hamster oviducts is decreased in vitro by exposure to solutions of mainstream and sidestream cigarette smoke. Biol Reprod 53:29–37PubMedCrossRef
70.
go back to reference Riveles K, Roza R, Arey J, Talbot P (2004) Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning. Reprod Biol Endocrinol 2:23PubMedCrossRef Riveles K, Roza R, Arey J, Talbot P (2004) Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning. Reprod Biol Endocrinol 2:23PubMedCrossRef
71.
go back to reference Talbot P, Riveles K (2005) Smoking and reproduction: the oviduct as a target of cigarette smoke. Reprod Biol Endocrinol 3:52PubMedCrossRef Talbot P, Riveles K (2005) Smoking and reproduction: the oviduct as a target of cigarette smoke. Reprod Biol Endocrinol 3:52PubMedCrossRef
72.
go back to reference Li YY, Li L, Hwang IS, Tang F, O WS (2008) Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary. Biol Reprod 79:200–208PubMedCrossRef Li YY, Li L, Hwang IS, Tang F, O WS (2008) Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary. Biol Reprod 79:200–208PubMedCrossRef
73.
go back to reference Evans J, Catalano RD, Morgan K, Critchley HO, Millar RP, Jabbour HN (2008) Prokineticin 1 signaling and gene regulation in early human pregnancy. Endocrinology 149:2877–2887PubMedCrossRef Evans J, Catalano RD, Morgan K, Critchley HO, Millar RP, Jabbour HN (2008) Prokineticin 1 signaling and gene regulation in early human pregnancy. Endocrinology 149:2877–2887PubMedCrossRef
74.
go back to reference Clayton HB, Schieve LA, Peterson HB, Jamieson DJ, Reynolds MA, Wright VC (2006) Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol 107:595–604PubMedCrossRef Clayton HB, Schieve LA, Peterson HB, Jamieson DJ, Reynolds MA, Wright VC (2006) Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol 107:595–604PubMedCrossRef
75.
go back to reference Strandell A, Thorburn J, Hamberger L (1999) Risk factors for ectopic pregnancy in assisted reproduction. Fertil Steril 71:282–286PubMedCrossRef Strandell A, Thorburn J, Hamberger L (1999) Risk factors for ectopic pregnancy in assisted reproduction. Fertil Steril 71:282–286PubMedCrossRef
76.
go back to reference Weigert M, Gruber D, Pernicka E, Bauer P, Feichtinger W (2009) Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in in vitro fertilization-embryo transfer patients. J Assist Reprod Genet 26:13–17PubMedCrossRef Weigert M, Gruber D, Pernicka E, Bauer P, Feichtinger W (2009) Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in in vitro fertilization-embryo transfer patients. J Assist Reprod Genet 26:13–17PubMedCrossRef
77.
go back to reference Furlong LA (2002) Ectopic pregnancy risk when contraception fails. A review. J Reprod Med 47:881–885PubMed Furlong LA (2002) Ectopic pregnancy risk when contraception fails. A review. J Reprod Med 47:881–885PubMed
78.
go back to reference McCord ML, Muram D, Buster JE, Arheart KL, Stovall TG, Carson SA (1996) Single serum progesterone as a screen for ectopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance. Fertil Steril 66:513–516PubMed McCord ML, Muram D, Buster JE, Arheart KL, Stovall TG, Carson SA (1996) Single serum progesterone as a screen for ectopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance. Fertil Steril 66:513–516PubMed
79.
go back to reference Daponte A, Pournaras S, Zintzaras E, Kallitsaris A, Lialios G, Maniatis AN (2005) The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy. Hum Reprod 20:3163–3166PubMedCrossRef Daponte A, Pournaras S, Zintzaras E, Kallitsaris A, Lialios G, Maniatis AN (2005) The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy. Hum Reprod 20:3163–3166PubMedCrossRef
80.
go back to reference Miller WC, Ford CA, Morris M, Handcock MS, Schmitz JL, Hobbs MM, Cohen MS, Harris KM, Udry JR (2004) Prevalence of chlamydial and gonococcal infections among young adults in the United States. JAMA 291:2229–2236PubMedCrossRef Miller WC, Ford CA, Morris M, Handcock MS, Schmitz JL, Hobbs MM, Cohen MS, Harris KM, Udry JR (2004) Prevalence of chlamydial and gonococcal infections among young adults in the United States. JAMA 291:2229–2236PubMedCrossRef
81.
go back to reference Kucera-Sliutz E, Schiebel I, Konig F, Leodolter S, Sliutz G, Koelbl H (2002) Vascular endothelial growth factor (VEGF) and discrimination between abnormal intrauterine and ectopic pregnancy. Hum Reprod 17:3231–3234PubMedCrossRef Kucera-Sliutz E, Schiebel I, Konig F, Leodolter S, Sliutz G, Koelbl H (2002) Vascular endothelial growth factor (VEGF) and discrimination between abnormal intrauterine and ectopic pregnancy. Hum Reprod 17:3231–3234PubMedCrossRef
82.
go back to reference Felemban A, Sammour A, Tulandi T (2002) Serum vascular endothelial growth factor as a possible marker for early ectopic pregnancy. Hum Reprod 17:490–492PubMedCrossRef Felemban A, Sammour A, Tulandi T (2002) Serum vascular endothelial growth factor as a possible marker for early ectopic pregnancy. Hum Reprod 17:490–492PubMedCrossRef
83.
go back to reference Jae KL, Min JOh, Joong SS, Kyung JL, Jung HN, Jung HC, Jin DC, Dong HC, In-Soo K, Paul IL (2005) Clinical effectiveness of urinary human chorionic gonadotropin related protein (hCGRP) quantification for diagnosis of ectopic pregnancy. J Korean Med Sci 20:461–467CrossRef Jae KL, Min JOh, Joong SS, Kyung JL, Jung HN, Jung HC, Jin DC, Dong HC, In-Soo K, Paul IL (2005) Clinical effectiveness of urinary human chorionic gonadotropin related protein (hCGRP) quantification for diagnosis of ectopic pregnancy. J Korean Med Sci 20:461–467CrossRef
84.
go back to reference Kaplan BC, Dart RG, Moskos M, Kuligowska E, Chun B, Adel HM (1996) Ectopic pregnancy: prospective study with improved diagnostic accuracy. Ann Emerg Med 28:10–17PubMedCrossRef Kaplan BC, Dart RG, Moskos M, Kuligowska E, Chun B, Adel HM (1996) Ectopic pregnancy: prospective study with improved diagnostic accuracy. Ann Emerg Med 28:10–17PubMedCrossRef
85.
go back to reference Kohn MA, Kerr K, Malkevich D, ONeil N, Kerr MJ, Kaplan BC (2003) Beta-human chorionic gonadotropin levels and the likelihood of ectopic pregnancy in emergency department patients with abdominal pain or vaginal bleeding. Acad Emerg Med 10:119–126PubMedCrossRef Kohn MA, Kerr K, Malkevich D, ONeil N, Kerr MJ, Kaplan BC (2003) Beta-human chorionic gonadotropin levels and the likelihood of ectopic pregnancy in emergency department patients with abdominal pain or vaginal bleeding. Acad Emerg Med 10:119–126PubMedCrossRef
86.
go back to reference Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W (2004) Symptomatic patients with an early viable intrauterine pregnancy: hCG curves redefined. Obstet Gynecol 104:50–55PubMedCrossRef Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W (2004) Symptomatic patients with an early viable intrauterine pregnancy: hCG curves redefined. Obstet Gynecol 104:50–55PubMedCrossRef
87.
go back to reference Heather M, Hanadi B, Trevor B, Togas T (2005) Diagnosis and treatment of ectopic pregnancy progesterone measurement. CMAJ 173(8):905–912CrossRef Heather M, Hanadi B, Trevor B, Togas T (2005) Diagnosis and treatment of ectopic pregnancy progesterone measurement. CMAJ 173(8):905–912CrossRef
88.
go back to reference Stovall TG, Ling FW, Gray LA, Carson SA, Buster JE (1991) Methotrexate treatment of unruptured ectopic pregnancy: a report of 100 cases. Obstet Gynecol 77(5):749–753PubMed Stovall TG, Ling FW, Gray LA, Carson SA, Buster JE (1991) Methotrexate treatment of unruptured ectopic pregnancy: a report of 100 cases. Obstet Gynecol 77(5):749–753PubMed
89.
go back to reference Mol BW, Hajenius PJ, Engelsbel S, Ankum WM, van der Veen F, Hemrika DJ (1999) Can noninvasive diagnostic tools predict tubal rupture or active bleeding in patients with tubal pregnancy? Fertil Steril 71:167–173PubMedCrossRef Mol BW, Hajenius PJ, Engelsbel S, Ankum WM, van der Veen F, Hemrika DJ (1999) Can noninvasive diagnostic tools predict tubal rupture or active bleeding in patients with tubal pregnancy? Fertil Steril 71:167–173PubMedCrossRef
90.
go back to reference Dart R, Ramanujam P, Dart L (2002) Progesterone as a predictor of ectopic pregnancy when the ultrasound is indeterminate. Am J Emerg Med 20:575–579PubMedCrossRef Dart R, Ramanujam P, Dart L (2002) Progesterone as a predictor of ectopic pregnancy when the ultrasound is indeterminate. Am J Emerg Med 20:575–579PubMedCrossRef
91.
go back to reference Buckley RG, King KJ, Disney JD, Riffenburgh RH, Gorman JD, Klausen JH (2000) Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients. Ann Emerg Med 36:95–100PubMedCrossRef Buckley RG, King KJ, Disney JD, Riffenburgh RH, Gorman JD, Klausen JH (2000) Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients. Ann Emerg Med 36:95–100PubMedCrossRef
92.
go back to reference Elson J, Tailor A, Banerjee S, Salim R, Hillaby K, Jurkovic D (2004) Expectant management of tubal ectopic pregnancy: prediction of successful outcome using decision tree analysis. Ultrasound Obstet Gynecol 23:552–556PubMedCrossRef Elson J, Tailor A, Banerjee S, Salim R, Hillaby K, Jurkovic D (2004) Expectant management of tubal ectopic pregnancy: prediction of successful outcome using decision tree analysis. Ultrasound Obstet Gynecol 23:552–556PubMedCrossRef
93.
go back to reference Condous G (2006) Ectopic pregnancy—risk factors and diagnosis. Aust Fam Physician 35:854–857PubMed Condous G (2006) Ectopic pregnancy—risk factors and diagnosis. Aust Fam Physician 35:854–857PubMed
94.
go back to reference Mehta TS, Levine D, Beckwith B (1997) Treatment of ectopic pregnancy: is a human chorionic gonadotropin level of 2,000 mIU/mL a reasonable threshold. Radiology 205:569–573PubMed Mehta TS, Levine D, Beckwith B (1997) Treatment of ectopic pregnancy: is a human chorionic gonadotropin level of 2,000 mIU/mL a reasonable threshold. Radiology 205:569–573PubMed
95.
go back to reference Murray H, Baakdah H, Bardell T, Tulandi T (2005) Diagnosis and treatment of ectopic pregnancy. CMAJ 173:905–912PubMedCrossRef Murray H, Baakdah H, Bardell T, Tulandi T (2005) Diagnosis and treatment of ectopic pregnancy. CMAJ 173:905–912PubMedCrossRef
96.
go back to reference Kirsch JD, Scoutt LM (2010) Imaging of ectopic pregnancy. Appl Radiol 39:10–25 Kirsch JD, Scoutt LM (2010) Imaging of ectopic pregnancy. Appl Radiol 39:10–25
97.
go back to reference Cano AR, Borruel NS, Díez MP (2009) Role of multidetector CT in the management of acute female pelvic disease. Emerg Radiol 16:453–472CrossRef Cano AR, Borruel NS, Díez MP (2009) Role of multidetector CT in the management of acute female pelvic disease. Emerg Radiol 16:453–472CrossRef
98.
go back to reference Pham H, Lin EC (2007) Adnexal ring of ectopic pregnancy detected by contrast-enhanced CT. Abdom Imaging 32(1):56–58PubMedCrossRef Pham H, Lin EC (2007) Adnexal ring of ectopic pregnancy detected by contrast-enhanced CT. Abdom Imaging 32(1):56–58PubMedCrossRef
99.
go back to reference Shin BS, Park MH (2010) Incidental detection of interstitial pregnancy on CT imaging. Korean J Radiol 11(1):123–125PubMedCrossRef Shin BS, Park MH (2010) Incidental detection of interstitial pregnancy on CT imaging. Korean J Radiol 11(1):123–125PubMedCrossRef
100.
go back to reference Tamai K, Koyama T, Togashi K (2007) MR features of ectopic pregnancy. Eur Radiol 17(12):3236–3246PubMedCrossRef Tamai K, Koyama T, Togashi K (2007) MR features of ectopic pregnancy. Eur Radiol 17(12):3236–3246PubMedCrossRef
101.
go back to reference Yoshigi J, Yashiro N, Kinoshita T (2006) Diagnosis of ectopic pregnancy with MRI: efficacy of T2 weighted imaging. Magn Reson Med Sci 5(1):25–32PubMedCrossRef Yoshigi J, Yashiro N, Kinoshita T (2006) Diagnosis of ectopic pregnancy with MRI: efficacy of T2 weighted imaging. Magn Reson Med Sci 5(1):25–32PubMedCrossRef
102.
go back to reference Torry DS, Torry RJ (1997) Angiogenesis and the expression of vascular endothelial growth factor in endometrium and placenta. Am J Reprod Immunol 37:21–29PubMedCrossRef Torry DS, Torry RJ (1997) Angiogenesis and the expression of vascular endothelial growth factor in endometrium and placenta. Am J Reprod Immunol 37:21–29PubMedCrossRef
103.
go back to reference Ugurlu EN, Ozaksit G, Karaer A, Zulfikaroglu E, Atalay A, Ugur M (2008) The value of vascular endothelial growth factor, pregnancy-associated plasma protein-A, and progesterone for early differentiation of ectopic pregnancies, normal intrauterine pregnancies, and spontaneous miscarriages. Fertil Steril 91(5):1657–1661PubMedCrossRef Ugurlu EN, Ozaksit G, Karaer A, Zulfikaroglu E, Atalay A, Ugur M (2008) The value of vascular endothelial growth factor, pregnancy-associated plasma protein-A, and progesterone for early differentiation of ectopic pregnancies, normal intrauterine pregnancies, and spontaneous miscarriages. Fertil Steril 91(5):1657–1661PubMedCrossRef
104.
go back to reference Chandra L, Jain A (1995) Maternal serum creatine kinase as a biochemical marker of tubal pregnancy. Int J Gynaecol Obstet 49:21–23PubMedCrossRef Chandra L, Jain A (1995) Maternal serum creatine kinase as a biochemical marker of tubal pregnancy. Int J Gynaecol Obstet 49:21–23PubMedCrossRef
105.
go back to reference Saha PK, Gupta I, Ganguly NK (1999) Evaluation of serum creatine kinase as a diagnostic marker for tubal pregnancy. Aust N Z J Obstet Gynaecol 39:366–367PubMedCrossRef Saha PK, Gupta I, Ganguly NK (1999) Evaluation of serum creatine kinase as a diagnostic marker for tubal pregnancy. Aust N Z J Obstet Gynaecol 39:366–367PubMedCrossRef
106.
go back to reference Katsikis I, Rousso D, Farmakiotis D, Kourtis A, Diamanti KE, Zournatzi KV (2006) Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. Am J Obstet Gynecol 194:86–91PubMedCrossRef Katsikis I, Rousso D, Farmakiotis D, Kourtis A, Diamanti KE, Zournatzi KV (2006) Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. Am J Obstet Gynecol 194:86–91PubMedCrossRef
107.
go back to reference Yagami HT, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawa SA (1995) A metalloprotease-disintegrin participating in myoblast fusion. Nature 377:652–656CrossRef Yagami HT, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawa SA (1995) A metalloprotease-disintegrin participating in myoblast fusion. Nature 377:652–656CrossRef
108.
go back to reference Abe E, Mocharla H, Yamate T, Taguchi Y, Manolagas SC (1999) Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation. Calcif Tissue Int 64:508–515PubMedCrossRef Abe E, Mocharla H, Yamate T, Taguchi Y, Manolagas SC (1999) Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation. Calcif Tissue Int 64:508–515PubMedCrossRef
109.
go back to reference Huppertz B, Bartz C, Kokozidou M (2006) Trophoblast fusion: fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion. Micron 37:509–517PubMedCrossRef Huppertz B, Bartz C, Kokozidou M (2006) Trophoblast fusion: fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion. Micron 37:509–517PubMedCrossRef
110.
go back to reference Poon LC, Chelemen T, Granvillano O, Pandeva I, Nicolaides KH (2008) First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome. Obstet Gynecol 112:1082–1090PubMedCrossRef Poon LC, Chelemen T, Granvillano O, Pandeva I, Nicolaides KH (2008) First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome. Obstet Gynecol 112:1082–1090PubMedCrossRef
111.
go back to reference Laigaard J, Cuckle H, Wewer UM, Christiansen M (2006) Maternal serum ADAM12 levels in Down and Edwards’ syndrome pregnancies at 9–12 weeks’ gestation. Prenat Diagn 26:689–691PubMedCrossRef Laigaard J, Cuckle H, Wewer UM, Christiansen M (2006) Maternal serum ADAM12 levels in Down and Edwards’ syndrome pregnancies at 9–12 weeks’ gestation. Prenat Diagn 26:689–691PubMedCrossRef
112.
go back to reference Spencer K, Cowans NJ, Stamatopoulou A (2008) ADAM12s in maternal serum as a potential marker of pre-eclampsia. Prenat Diagn 28:212–216PubMedCrossRef Spencer K, Cowans NJ, Stamatopoulou A (2008) ADAM12s in maternal serum as a potential marker of pre-eclampsia. Prenat Diagn 28:212–216PubMedCrossRef
113.
go back to reference Swart P, Mol BWJ, Vander VF, Van BM, Redekop WK, Bossuyt PMM (1995) The accuracy of hysterosalpingography in the diagnosis of tubal pathology: a meta-analysis. Fertil Steril 64:486–491PubMed Swart P, Mol BWJ, Vander VF, Van BM, Redekop WK, Bossuyt PMM (1995) The accuracy of hysterosalpingography in the diagnosis of tubal pathology: a meta-analysis. Fertil Steril 64:486–491PubMed
114.
go back to reference Elito J Jr, Han KK, Camano L (2005) Tubal patency after clinical treatment of unruptured ectopic pregnancy. Int J Gynecol Obstet 88:309–313CrossRef Elito J Jr, Han KK, Camano L (2005) Tubal patency after clinical treatment of unruptured ectopic pregnancy. Int J Gynecol Obstet 88:309–313CrossRef
115.
go back to reference Mol BWJ, Swart P, Bossuyt PMM, Van BM, Vander VF (1996) Reproducibility of the interpretation of hysterosalpingography in the diagnosis of tubal pathology. Hum Reprod 11:1204–1208PubMedCrossRef Mol BWJ, Swart P, Bossuyt PMM, Van BM, Vander VF (1996) Reproducibility of the interpretation of hysterosalpingography in the diagnosis of tubal pathology. Hum Reprod 11:1204–1208PubMedCrossRef
116.
go back to reference Papaioannou S, Afnan M, Jafettas J (2007) Tubal assessment tests: still have not found what we are looking for. Reprod Bio Med Online 15:376–382CrossRef Papaioannou S, Afnan M, Jafettas J (2007) Tubal assessment tests: still have not found what we are looking for. Reprod Bio Med Online 15:376–382CrossRef
117.
go back to reference Fertility Assessment and Treatment for People with Fertility Problems (2004) Clinical Guideline. RCOG Press, London Fertility Assessment and Treatment for People with Fertility Problems (2004) Clinical Guideline. RCOG Press, London
118.
go back to reference Sowter M, Farquhar C, Petrie K, Gudex G (2001) A randomized trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy. Brit J Obstet Gynaecol 108:192–203CrossRef Sowter M, Farquhar C, Petrie K, Gudex G (2001) A randomized trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy. Brit J Obstet Gynaecol 108:192–203CrossRef
119.
go back to reference Seror V, Gelfucci F, Gerbaud L, Pouly JL, Fernandez H, Job Spira N, Bouyer J, Coste J (2007) Care pathways for ectopic pregnancy: a population-based cost-effectiveness analysis. Fertil Steril 87:737–748PubMedCrossRef Seror V, Gelfucci F, Gerbaud L, Pouly JL, Fernandez H, Job Spira N, Bouyer J, Coste J (2007) Care pathways for ectopic pregnancy: a population-based cost-effectiveness analysis. Fertil Steril 87:737–748PubMedCrossRef
120.
go back to reference Carson SA, Stovall TG, Ling FW, Buster JE (1991) Low human chorionic somatomammotropin fails to predict spontaneous resolution of unruptured ectopic pregnancies. Fertil Steril 55:629–630PubMed Carson SA, Stovall TG, Ling FW, Buster JE (1991) Low human chorionic somatomammotropin fails to predict spontaneous resolution of unruptured ectopic pregnancies. Fertil Steril 55:629–630PubMed
121.
go back to reference Quasim SM, Trias A, Sachdev R, Kenmann E (1996) Evaluation of serum creatinine kinase levels in ectopic pregnancy. Fertil Steril 65:443–445 Quasim SM, Trias A, Sachdev R, Kenmann E (1996) Evaluation of serum creatinine kinase levels in ectopic pregnancy. Fertil Steril 65:443–445
122.
go back to reference Rajesh V, Lawrence M (2002) Evidence-based management of ectopic pregnancy. Curr Obstet Gynaecol 12:191–199CrossRef Rajesh V, Lawrence M (2002) Evidence-based management of ectopic pregnancy. Curr Obstet Gynaecol 12:191–199CrossRef
123.
go back to reference Barnhart KT, Fay CA, Suescum M, Sammel MD, Appleby D, Shaunik A, Dean AJ (2011) Clinical factors affecting the accuracy of ultrasonography in symptomatic first-trimester pregnancy. Obstet Gynecol 117:299–306PubMedCrossRef Barnhart KT, Fay CA, Suescum M, Sammel MD, Appleby D, Shaunik A, Dean AJ (2011) Clinical factors affecting the accuracy of ultrasonography in symptomatic first-trimester pregnancy. Obstet Gynecol 117:299–306PubMedCrossRef
124.
go back to reference American College of Obstetricians and Gynecologists (1998) Medical management of tubal pregnancy. ACOG Practice Bulletin No. 3. Obstet Gynecol 92:1–7CrossRef American College of Obstetricians and Gynecologists (1998) Medical management of tubal pregnancy. ACOG Practice Bulletin No. 3. Obstet Gynecol 92:1–7CrossRef
125.
go back to reference Rodrigues SP, de Burlet KJ, Hiemstra E, Twijnstra AR, van Zwet EW, Trimbos-Kemper TC, Jansen FW (2012) Ectopic pregnancy: when is expectant management safe? Gynecol Surg 9:421–426PubMedCrossRef Rodrigues SP, de Burlet KJ, Hiemstra E, Twijnstra AR, van Zwet EW, Trimbos-Kemper TC, Jansen FW (2012) Ectopic pregnancy: when is expectant management safe? Gynecol Surg 9:421–426PubMedCrossRef
126.
go back to reference Raughley MJ, Frishman GN (2007) Local treatment of ectopic pregnancy. Semin Reprod Med 25(2):99–115PubMedCrossRef Raughley MJ, Frishman GN (2007) Local treatment of ectopic pregnancy. Semin Reprod Med 25(2):99–115PubMedCrossRef
127.
go back to reference van Mello NM, Mol F, Mol BW, Hajenius PJ (2009) Conservative management of tubal ectopic pregnancy. Best Pract Res 23:509–518CrossRef van Mello NM, Mol F, Mol BW, Hajenius PJ (2009) Conservative management of tubal ectopic pregnancy. Best Pract Res 23:509–518CrossRef
128.
go back to reference Hajenius PJ, Mol BWJ, Ankum WM, Van der Veen F (2003) Systemic and local medical therapy of tubal pregnancy. In: Timmerman D, Deprest J, Bourne T (eds) Ultrasound and endoscopic surgery in obstetrics and gynaecology. A combined approach to diagnosis and treatment. Springer, London. ISBN 3540762124 Hajenius PJ, Mol BWJ, Ankum WM, Van der Veen F (2003) Systemic and local medical therapy of tubal pregnancy. In: Timmerman D, Deprest J, Bourne T (eds) Ultrasound and endoscopic surgery in obstetrics and gynaecology. A combined approach to diagnosis and treatment. Springer, London. ISBN 3540762124
129.
go back to reference Condous G, Okaro E, Khalid A, Lu C, Van HS, Timmerman D (2005) A prospective valuation of a single-visit strategy to manage pregnancies of unknown location. Hum Reprod 20:1398–1403PubMedCrossRef Condous G, Okaro E, Khalid A, Lu C, Van HS, Timmerman D (2005) A prospective valuation of a single-visit strategy to manage pregnancies of unknown location. Hum Reprod 20:1398–1403PubMedCrossRef
130.
131.
go back to reference Jeng CJ, Ko ML, Shen J (2007) Transvaginal ultrasound-guided treatment of cervical pregnancy. Obstet Gynecol 109:1076–1082PubMedCrossRef Jeng CJ, Ko ML, Shen J (2007) Transvaginal ultrasound-guided treatment of cervical pregnancy. Obstet Gynecol 109:1076–1082PubMedCrossRef
132.
go back to reference Lin CY, Chang CY, Chang HM, Tsai EM (2008) Cervical pregnancy treated with systemic methotrexate administration and resectoscopy. Taiwan J Obstet Gynecol 47:4 Lin CY, Chang CY, Chang HM, Tsai EM (2008) Cervical pregnancy treated with systemic methotrexate administration and resectoscopy. Taiwan J Obstet Gynecol 47:4
133.
go back to reference Sijanovic S, Vidosavljevic D, Sijanovic I (2011) Methotrexate in local treatment of cervical heterotopic pregnancy with successful perinatal outcome: case report. J Obstet Gynaecol Res 37:1241–1245PubMedCrossRef Sijanovic S, Vidosavljevic D, Sijanovic I (2011) Methotrexate in local treatment of cervical heterotopic pregnancy with successful perinatal outcome: case report. J Obstet Gynaecol Res 37:1241–1245PubMedCrossRef
134.
go back to reference Gabbur N, Sherer DM, Hellmann M (2006) Do serum beta-human chorionic gonadotropin levels on day 4 following methotrexate treatment of patients with ectopic pregnancy predict successful single-dose therapy? Am J Perinatol 23:193–196PubMedCrossRef Gabbur N, Sherer DM, Hellmann M (2006) Do serum beta-human chorionic gonadotropin levels on day 4 following methotrexate treatment of patients with ectopic pregnancy predict successful single-dose therapy? Am J Perinatol 23:193–196PubMedCrossRef
135.
go back to reference Barnhart KT, Gosman G, Ashby R, Sammel M (2003) The medical management of ectopic pregnancy: a meta-analysis comparing “single dose” and “multidose” regimens. Obstet Gynecol 101:778–784PubMedCrossRef Barnhart KT, Gosman G, Ashby R, Sammel M (2003) The medical management of ectopic pregnancy: a meta-analysis comparing “single dose” and “multidose” regimens. Obstet Gynecol 101:778–784PubMedCrossRef
136.
go back to reference Kirk E, Condous G, Van Calster B (2007) A validation of the most commonly used protocol to predict the success of single-dose methotrexate in the treatment of ectopic pregnancy. Hum Reprod 22:858–863PubMedCrossRef Kirk E, Condous G, Van Calster B (2007) A validation of the most commonly used protocol to predict the success of single-dose methotrexate in the treatment of ectopic pregnancy. Hum Reprod 22:858–863PubMedCrossRef
137.
go back to reference Barnhart K, Hummel AC, Sammel MD, Menon S, Jain J, Chakhtoura N (2007) Use of “2-dose” regimen of methotrexate to treat ectopic pregnancy. Fertil Steril 87:250–256PubMedCrossRef Barnhart K, Hummel AC, Sammel MD, Menon S, Jain J, Chakhtoura N (2007) Use of “2-dose” regimen of methotrexate to treat ectopic pregnancy. Fertil Steril 87:250–256PubMedCrossRef
138.
go back to reference Hossam O, Hamed A, Salah R, Ahmed A, Abdullah A (2012) Comparison of double- and single-dose methotrexate protocols for treatment of ectopic pregnancy. Alghasham Int J Gynecol Obstet 116:67–71CrossRef Hossam O, Hamed A, Salah R, Ahmed A, Abdullah A (2012) Comparison of double- and single-dose methotrexate protocols for treatment of ectopic pregnancy. Alghasham Int J Gynecol Obstet 116:67–71CrossRef
139.
go back to reference Buster JE, Carson SA (1995) Ectopic pregnancy; new advances in diagnosis and treatment. Curr Opinion Obstet Gynecol 7:168–176CrossRef Buster JE, Carson SA (1995) Ectopic pregnancy; new advances in diagnosis and treatment. Curr Opinion Obstet Gynecol 7:168–176CrossRef
140.
go back to reference Fritz MA, Speroff L (2011) Clinical gynecologic endocrinology and infertility, 8th edn. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia Fritz MA, Speroff L (2011) Clinical gynecologic endocrinology and infertility, 8th edn. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia
141.
go back to reference Lozeau AM, Potter B (2005) Diagnosis and management of ectopic pregnancy. Am Fam Physician 1707–14(19):20 Lozeau AM, Potter B (2005) Diagnosis and management of ectopic pregnancy. Am Fam Physician 1707–14(19):20
142.
go back to reference Hajenius PJ, Mol BW, Bossuyt PM, Ankum WM, Vander VF (2000) Interventions for tubal ectopic pregnancy. Cochrane Database Syst Rev (2):CD000324 Hajenius PJ, Mol BW, Bossuyt PM, Ankum WM, Vander VF (2000) Interventions for tubal ectopic pregnancy. Cochrane Database Syst Rev (2):CD000324
143.
go back to reference Hoppe DE, Bekkar BE, Nager CW (1994) Single-dose systemic methotrexate for the treatment of persistent ectopic pregnancy after conservative surgery. Obstet Gynecol 83:51–54PubMed Hoppe DE, Bekkar BE, Nager CW (1994) Single-dose systemic methotrexate for the treatment of persistent ectopic pregnancy after conservative surgery. Obstet Gynecol 83:51–54PubMed
144.
go back to reference Graczykowski JW, Mishell DR (1997) Methotrexate prophylaxis for persistent ectopic pregnancy after conservative treatment by salpingostomy. Obstet Gynecol 89:118–122PubMedCrossRef Graczykowski JW, Mishell DR (1997) Methotrexate prophylaxis for persistent ectopic pregnancy after conservative treatment by salpingostomy. Obstet Gynecol 89:118–122PubMedCrossRef
145.
go back to reference Seifer DB (1997) Persistent ectopic pregnancy: an argument for heightened vigilance and patient compliance. Fertil Steril 68:402–404PubMedCrossRef Seifer DB (1997) Persistent ectopic pregnancy: an argument for heightened vigilance and patient compliance. Fertil Steril 68:402–404PubMedCrossRef
Metadata
Title
Ectopic pregnancy: a review
Authors
Poonam Rana
Imran Kazmi
Rajbala Singh
Muhammad Afzal
Fahad A. Al-Abbasi
Ali Aseeri
Rajbir Singh
Ruqaiyah Khan
Firoz Anwar
Publication date
01-10-2013
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-013-2929-2

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