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Archives of Gynecology and Obstetrics

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01-01-2012 | Materno-Fetal Medicine

Placental α-microglobulin-1 to detect uncertain rupture of membranes in a European cohort of pregnancies

Authors: Ariane Birkenmaier, Jean-Jacques Ries, Jens Kuhle, Nicole Bürki, Olav Lapaire, Irene Hösli

Published in: Archives of Gynecology and Obstetrics | Issue 1/2012

Abstract

Purpose

We evaluated the performance of the placental alpha-microglobulin-1 immunoassay (AmniSure^®, AT) in cervicovaginal secretions in patients with uncertain rupture of membranes (ROM) and investigated the influence of the examiners experience.

Methods

This prospective cohort study was performed in pregnant women (17–42 weeks of gestation) with signs of possible ROM. Evaluation included clinical assessment, examination for cervical leakage, Nitrazine test and measurement of the amniotic fluid index by ultrasound and AT. ROM occurrence was based on review of the medical records after delivery.

Results

199 women were included. AT had a sensitivity of 94.4%; specificity of 98.6%; positive predictive value, 96.2%; negative predictive value, 98.0%. Clinical assessment showed a sensitivity of 72.2%; specificity of 97.8%; positive predictive value, 92.9%; negative predictive value, 90.6%. AT was more sensitive for diagnosing ROM (p = 0.00596) compared to clinical assessment, independent of the examiners experience. Furthermore, the sole use of AT reduced costs by 58.4% compared to clinical assessment.

Conclusions

AT was more sensitive compared to clinical assessment, independent of the examiners experience and gestational age. Our data extend its use in patients with uncertain ROM. Moreover, AT seems to be a cost-effective approach in the assessment of these patients.

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Title: Placental α-microglobulin-1 to detect uncertain rupture of membranes in a European cohort of pregnancies
Authors: Ariane Birkenmaier
Jean-Jacques Ries
Jens Kuhle
Nicole Bürki
Olav Lapaire
Irene Hösli
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 1/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-1895-9

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Placental α-microglobulin-1 to detect uncertain rupture of membranes in a European cohort of pregnancies

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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