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Archives of Gynecology and Obstetrics

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01-04-2011 | Materno-Fetal Medicine

A significant linear association exists between advanced maternal age and adverse perinatal outcome

Authors: Shimrit Salem Yaniv, Amalia Levy, Arnon Wiznitzer, Gershon Holcberg, Moshe Mazor, Eyal Sheiner

Published in: Archives of Gynecology and Obstetrics | Issue 4/2011

Abstract

Objective

The present study was aimed to investigate perinatal outcome of elderly nulliparous patients.

Study design

A retrospective study was performed comparing pregnancy outcomes of nulliparous patients at three age groups: less than 35 years (reference group), 35–40 years, and above 40 years. The linear-by-linear association test was used to examine linear association between advanced maternal age and adverse pregnancy outcomes. A multiple logistic regression model was used to control for confounders.

Results

Out of 45,033 nulliparous women with singleton gestations, 1,036 were of women over the age of 35, and 188 over 40. A significant linear association was documented between advanced maternal age and adverse outcomes, such as intra uterine growth restriction, low birth weight, congenital malformations, and perinatal mortality. Using a multiple logistic regression model, controlling for gestational age, IUGR and malformations, advanced maternal age was not found to be an independent risk factor for perinatal mortality (adjusted odds ratio = 1.04, 95% confidence interval 0.7–1.4).

Conclusion

A significant linear association exists between advanced maternal age and adverse maternal and perinatal outcomes. Nevertheless, in our population, advanced maternal age is not an independent risk factor for perinatal mortality.

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Title: A significant linear association exists between advanced maternal age and adverse perinatal outcome
Authors: Shimrit Salem Yaniv
Amalia Levy
Arnon Wiznitzer
Gershon Holcberg
Moshe Mazor
Eyal Sheiner
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 4/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-010-1459-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

A significant linear association exists between advanced maternal age and adverse perinatal outcome

Abstract

Objective

Study design

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Study design

Results

Conclusion

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