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01-05-2007 | Review Article

CD83: an update on functions and prospects of the maturation marker of dendritic cells

Authors: Alexander T. Prechtel, Alexander Steinkasserer

Published in: Archives of Dermatological Research | Issue 2/2007

Abstract

CD83 is one of the most characteristic cell surface markers for fully matured dendritic cells (DCs). In their function as antigen presenting cells they induce T-cell mediated immune responses. In this review we provide an overview on well described and proposed functions of this molecule as well as on very recent insights and new hypothesis. Already the CD83 messenger RNA processing differs remarkably from the processing of other cellular mRNAs: instead of the usual TAP mRNA export pathway, the CD83 mRNA is exported by the specific CRM1-mediated pathway, utilized only by a minority of cellular mRNAs. On the protein level, two different isoforms of CD83 exist: a membrane-bound and a soluble form. The isoforms are generated by different subsets of cells, including DCs, T-cells and B-cells, and also differ in their biological function. While the membrane-bound CD83 is of immune stimulatory capacity, activates T-cells and is important for the generation of thymocytes, the soluble CD83 has the opposite effect and has an immune inhibitory capacity. Due to its immune inhibitory function, CD83 has great potential for treatment of autoimmune diseases, for organ transplantations, and for immunotherapy, just to name a few examples. Moreover, some viruses prevent recognition by the host’s immune system by specifically targeting CD83 surface expression.

Al-Alwan MM, Liwski RS, Haeryfar SM, Baldridge WH, Hoskin DW, Rowden G, West KA (2003) Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. J Immunol 171(9):4479–4483PubMed

Al-Alwan MM, Rowden G, Lee TD, West KA (2001) The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J Immunol 166(3):1452–1456PubMed

Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, Klimpel GR, Godowski P, Zychlinsky A (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285(5428):736–739PubMed

Antic D, Keene JD (1997) Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. Am J Hum Genet 61(2):273–278PubMed

Ardavin C (1997) Thymic dendritic cells. Immunol Today 18(7):350–361PubMed

Arrode G, Boccaccio C, Abastado JP, Davrinche C (2002) Cross-presentation of human cytomegalovirus pp65 (UL83) to CD8+ T cells is regulated by virus-induced, soluble-mediator-dependent maturation of dendritic cells. J Virol 76(1):142–150PubMed

Bakheet T, Williams BR, Khabar KS (2003) ARED 2.0: an update of AU-rich element mRNA database. Nucleic Acids Res 31(1):421–423PubMed

Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392(6673):245–252PubMed

Becker Y (2003) Immunological and regulatory functions of uninfected and virus infected immature and mature subtypes of dendritic cells—a review. Virus Genes 26(2):119–130PubMed

10.

Bednenko J, Cingolani G, Gerace L (2003) Nucleocytoplasmic transport: navigating the channel. Traffic 4(3):127–135PubMed

11.

Berchtold S, Jones T, Muhl-Zurbes P, Sheer D, Schuler G, Steinkasserer A (1999) The human dendritic cell marker CD83 maps to chromosome 6p23. Ann Hum Genet 63(Pt 2):181–183PubMed

12.

Berchtold S, Muhl-Zurbes P, Heufler C, Winklehner P, Schuler G, Steinkasserer A (1999) Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule which is specifically upregulated during dendritic cell maturation. FEBS Lett 461(3):211–216PubMed

13.

Berchtold S, Muhl-Zurbes P, Maczek E, Golka A, Schuler G, Steinkasserer A (2002) Cloning and characterization of the promoter region of the human CD83 gene. Immunobiology 205(3):231–246PubMed

14.

Bevec D, Hauber J (1997) Eukaryotic initiation factor 5A activity and HIV-1 Rev function. Biol Signals 6(3):124–133PubMed

15.

Brennan CM, Steitz JA (2001) HuR and mRNA stability. Cell Mol Life Sci 58(2):266–277PubMed

16.

Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285(5428):732–736PubMed

17.

Burns S, Thrasher AJ (2004) Dendritic cells: the bare bones of immunity. Curr Biol 14(22):R965–R967PubMed

18.

Cao W, Lee SH, Lu J (2005) CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. Biochem J 385(Pt 1):85–93PubMed

19.

Cella M, Salio M, Sakakibara Y, Langen H, Julkunen I, Lanzavecchia A (1999) Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J Exp Med 189(5):821–829PubMed

20.

Chen CY, Shyu AB (1995) AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci 20(11):465–470PubMed

21.

Davis DM, Dustin ML (2004) What is the importance of the immunological synapse? Trends Immunol 25(6):323–327PubMed

22.

Dilioglou S, Cruse JM, Lewis RE (2003) Function of CD80 and CD86 on monocyte- and stem cell-derived dendritic cells. Exp Mol Pathol 75(3):217–227PubMed

23.

Dudziak D, Nimmerjahn F, Bornkamm GW, Laux G (2005) Alternative splicing generates putative soluble CD83 proteins that inhibit T cell proliferation. J Immunol 174(11):6672–6676PubMed

24.

Dudziak D, Kieser A, Dirmeier U, Nimmerjahn F, Berchtold S, Steinkasserer A, Marschall G, Hammerschmidt W, Laux G, Bornkamm GW (2003) Latent membrane protein 1 of Epstein–Barr virus induces CD83 by the NF-{kappa}B signaling pathway. J Virol 77(15):8290–8298PubMed

25.

Dustin ML, Cooper JA (2000) The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol 1(1):23–29PubMed

26.

Elfgang C, Rosorius O, Hofer L, Jaksche H, Hauber J, Bevec D (1999) Evidence for specific nucleocytoplasmic transport pathways used by leucine-rich nuclear export signals. Proc Natl Acad Sci USA 96(11):6229–6234PubMed

27.

Elliott DJ, Stutz F, Lescure A, Rosbash M (1994) mRNA nuclear export. Curr Opin Genet Dev 4(2):305–309PubMed

28.

Fahrenkrog B, Aebi U (2003) The nuclear pore complex: nucleocytoplasmic transport and beyond. Nat Rev Mol Cell Biol 4(10):757–766PubMed

29.

Fan XC, Steitz JA (1998) HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc Natl Acad Sci USA 95(26):15293–15298PubMed

30.

Flores-Romo L (2001) In vivo maturation and migration of dendritic cells. Immunology 102(3):255–262PubMed

31.

Fries B, Heukeshoven J, Hauber I, Gruttner C, Stocking C, Kehlenbach RH, Hauber J, Chemnitz J (2007) Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression. J Biol Chem (in press)

32.

Fujimoto Y, Tedder TF (2006) CD83: a regulatory molecule of the immune system with great potential for therapeutic application. J Med Dent Sci 53(2):85–91PubMed

33.

Fujimoto Y, Tu L, Miller AS, Bock C, Fujimoto M, Doyle C, Steeber DA, Tedder TF (2002) CD83 expression influences CD4+ T cell development in the thymus. Cell 108(6):755–767PubMed

34.

Garcia-Martinez LF, Appleby MW, Staehling-Hampton K, Andrews DM, Chen Y, McEuen M, Tang P, Rhinehart RL, Proll S, Paeper B, Brunkow ME, Grandea AG III, Howard ED, Walker DE, Charmley P, Jonas M, Shaw S, Latham JA, Ramsdell F (2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol 173(5):2995–3001PubMed

35.

Gold R, Linington C, Lassmann H (2006) Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129(Pt 8):1953–1971PubMed

36.

Guhaniyogi J, Brewer G (2001) Regulation of mRNA stability in mammalian cells. Gene 265(1–2):11–23PubMed

37.

Gunn MD (2003) Chemokine mediated control of dendritic cell migration and function. Semin Immunol 15(5):271–276PubMed

38.

Hirano N, Butler MO, Xia Z, Ansen S, von Bergwelt-Baildon MS, Neuberg D, Freeman GJ, Nadler LM (2006) Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity. Blood 107(4):1528–1536PubMed

39.

Hock BD, O’Donnell JL, Taylor K, Steinkasserer A, McKenzie JL, Rothwell AG, Summers KL (2006) Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients. Tissue Antigens 67(1):57–60PubMed

40.

Hock BD, Haring LF, Steinkasserer A, Taylor KG, Patton WN, McKenzie JL (2004) The soluble form of CD83 is present at elevated levels in a number of hematological malignancies. Leuk Res 28(3):237–241PubMed

41.

Hock BD, Kato M, McKenzie JL, Hart DNJ (2001) A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera. Int Immunol 13(7):959–967PubMed

42.

Iking-Konert C, Wagner C, Denefleh B, Hug F, Schneider M, Andrassy K, Hansch GM (2002) Up-regulation of the dendritic cell marker CD83 on polymorphonuclear neutrophils (PMN): divergent expression in acute bacterial infections and chronic inflammatory disease. Clin Exp Immunol 130(3):501–508PubMed

43.

Kaye J, Hsu ML, Sauron ME, Jameson SC, Gascoigne NR, Hedrick SM (1989) Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341(6244):746–749PubMed

44.

Keene JD (1999) Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc Natl Acad Sci USA 96(1):5–7PubMed

45.

King PH, Levine TD, Fremeau RT Jr, Keene JD (1994) Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3’ UTR of mRNA encoding the Id transcriptional repressor. J Neurosci 14(4):1943–1952PubMed

46.

Klagge IM, Schneider-Schaulies S (1999) Virus interactions with dendritic cells. J Gen Virol 80(4):823–833PubMed

47.

Kotzor N, Lechmann M, Zinser E, Steinkasserer A (2004) The soluble form of CD83 dramatically changes the cytoskeleton of dendritic cells. Immunobiology 209(1–2):129–140PubMed

48.

Kozlow EJ, Wilson GL, Fox CH, Kehrl JH (1993) Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes. Blood 81(2):454–461PubMed

49.

Kruse M, Rosorius O, Kratzer F, Bevec D, Kuhnt C, Steinkasserer A, Schuler G, Hauber J (2000) Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA. J Exp Med 191(9):1581–1590PubMed

50.

Kruse M, Rosorius O, Kratzer F, Stelz G, Kuhnt C, Schuler G, Hauber J, Steinkasserer A (2000) Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity. J Virol 74(15):7127–7136PubMed

51.

Lanzavecchia A, Sallusto F (2001) Antigen decoding by T lymphocytes: from synapses to fate determination. Nat Immunol 2(6):487–492PubMed

52.

Lanzavecchia A, Sallusto F (2001) Regulation of T cell immunity by dendritic cells. Cell 106(3):263–266PubMed

53.

Lechmann M, Kotzor N, Zinser E, Prechtel AT, Sticht H, Steinkasserer A (2005) CD83 is a dimer: comparative analysis of monomeric and dimeric isoforms. Biochem Biophys Res Commun 329(1):132–139PubMed

54.

Lechmann M, Kremmer E, Sticht H, Steinkasserer A (2002) Overexpression, purification, and biochemical characterization of the extracellular human CD83 domain and generation of monoclonal antibodies. Protein Exp Purif 24(3):445–452

55.

Lechmann M, Krooshoop DJEB, Dudziak D, Kremmer E, Kuhnt C, Figdor CG, Schuler G, Steinkasserer A (2001) The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells. J Exp Med 194(12):1813–1821PubMed

56.

Lekkerkerker AN, van Kooyk Y, Geijtenbeek TB (2006) Viral piracy: HIV-1 targets dendritic cells for transmission. Curr HIV Res 4(2):169–176PubMed

57.

Lin CL, Suri RM, Rahdon RA, Austyn JM, Roake JA (1998) Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation. Eur J Immunol 28(12):4114–4122PubMed

58.

Matzinger P, Guerder S (1989) Does T-cell tolerance require a dedicated antigen-presenting cell? Nature 338(6210):74–76PubMed

59.

McKinsey TA, Chu ZL, Tedder TF, Ballard DW (2000) Transcription factor NF-[kappa]B regulates inducible CD83 gene expression in activated T lymphocytes. Mol Immunol 37(12–13):783–788PubMed

60.

Mellman I, Steinman RM (2001) Dendritic cells: specialized and regulated antigen processing machines. Cell 106(3):255–258PubMed

61.

Mitchell P, Tollervey D (2001) mRNA turnover. Curr Opin Cell Biol 13(3):320–325PubMed

62.

Muthumani K, Hwang DS, Choo AY, Mayilvahanan S, Dayes NS, Thieu KP, Weiner DB (2005) HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro. Int Immunol 17(2):103–116PubMed

63.

Oehler L, Majdic O, Pickl WF, Stockl J, Riedl E, Drach J, Rappersberger K, Geissler K, Knapp W (1998) Neutrophil granulocyte-committed cells can be driven to acquire dendritic cell characteristics. J Exp Med 187(7):1019–1028PubMed

64.

Ohta Y, Landis E, Boulay T, Phillips RB, Collet B, Secombes CJ, Flajnik MF, Hansen JD (2004) Homologs of CD83 from elasmobranch and teleost fish. J Immunol 173(7):4553–4560PubMed

65.

Pardoll DM (2002) Spinning molecular immunology into successful immunotherapy. Nat Rev Immunol 2(4):227–238PubMed

66.

Park MH, Lee YB, Joe YA (1997) Hypusine is essential for eukaryotic cell proliferation. Biol Signals 6(3):115–123PubMed

67.

Park MH, Wolff EC, Folk JE (1993) Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation. Biofactors 4(2):95–104PubMed

68.

Prechtel AT, Chemnitz J, Schirmer S, Ehlers C, Langbein-Detsch I, Stulke J, Dabauvalle MC, Kehlenbach RH, Hauber J (2006) Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element. J Biol Chem 281(16):10912–10925PubMed

69.

Prechtel AT, Turza NM, Kobelt DJ, Eisemann JI, Coffin RS, McGrath Y, Hacker C, Ju X, Zenke M, Steinkasserer A (2005) Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration. J Gen Virol 86(Pt 6):1645–1657PubMed

70.

Prechtel AT, Turza NM, Theodoridis AA, Kummer M, Steinkasserer A (2006) Small interfering RNA (siRNA) delivery into monocyte-derived dendritic cells by electroporation. J Immunol Methods 311(1–2):139–152PubMed

71.

Raftery MJ, Schwab M, Eibert SM, Samstag Y, Walczak H, Schonrich G (2001) Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy. Immunity 15(6):997–1009PubMed

72.

Randolph GJ (2001) Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators. Semin Immunol 13(5):267–274PubMed

73.

Randolph GJ, Sanchez-Schmitz G, Angeli V (2005) Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. Springer Semin Immunopathol 26(3):273–287PubMed

74.

Reed R, Cheng H (2005) TREX, SR proteins and export of mRNA. Curr Opin Cell Biol 17(3):269–273PubMed

75.

Reed R, Magni K (2001) A new view of mRNA export: separating the wheat from the chaff. Nat Cell Biol 3(9):E201–E204PubMed

76.

Ridge JP, Di Rosa F, Matzinger P (1998) A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393(6684):474–478PubMed

77.

Rinaldo CR Jr, Piazza P (2004) Virus infection of dendritic cells: portal for host invasion and host defense. Trends Microbiol 12(7):337–345PubMed

78.

Rodriguez MS, Dargemont C, Stutz F (2004) Nuclear export of RNA. Biol Cell 96(8):639–655PubMed

79.

Rosorius O, Reichart B, Kratzer F, Heger P, Dabauvalle MC, Hauber J (1999) Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1. J Cell Sci 112(Pt 14):2369–2380PubMed

80.

Salio M, Cella M, Suter M, Lanzavecchia A (1999) Inhibition of dendritic cell maturation by herpes simplex virus. Eur J Immunol 29(10):3245–3253PubMed

81.

Sallusto F, Schaerli P, Loetscher P, Schaniel C, Lenig D, Mackay CR, Qin S, Lanzavecchia A (1998) Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 28(9):2760–2769PubMed

82.

Sallusto F, Lanzavecchia A (2002) The instructive role of dendritic cells on T-cell responses. Arthritis Res 4(Suppl 3):S127–S132PubMed

83.

Scholler N, Hayden-Ledbetter M, Hellstrom KE, Hellstrom I, Ledbetter JA (2001) CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells. J Immunol 166(6):3865–3872PubMed

84.

Scholler N, Hayden-Ledbetter M, Dahlin A, Hellstrom I, Hellstrom KE, Ledbetter JA (2002) Cutting edge: CD83 regulates the development of cellular immunity. J Immunol 168(6):2599–2602PubMed

85.

Senechal B, Boruchov AM, Reagan JL, Hart DN, Young JW (2004) Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83. Blood 103(11):4207–4215PubMed

86.

Shutt DC, Daniels KJ, Carolan EJ, Hill AC, Soll DR (2000) Changes in the motility, morphology, and F-actin architecture of human dendritic cells in an in vitro model of dendritic cell development. Cell Motil Cytoskeleton 46(3):200–221PubMed

87.

Sorg UR, Morse TM, Patton WN, Hock BD, Angus HB, Robinson BA, Colls BM, Hart DN (1997) Hodgkin’s cells express CD83, a dendritic cell lineage associated antigen. Pathology 29(3):294–299PubMed

88.

Sozzani S, Allavena P, D’Amico G, Luini W, Bianchi G, Kataura M, Imai T, Yoshie O, Bonecchi R, Mantovani A (1998) Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. J Immunol 161(3):1083–1086PubMed

89.

Sozzani S, Allavena P, Vecchi A, Mantovani A (2000) Chemokines and dendritic cell traffic. J Clin Immunol 20(3):151–160PubMed

90.

Steinman RM (2000) DC-SIGN: a guide to some mysteries of dendritic cells. Cell 100(5):491–494PubMed

91.

Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271–296PubMed

92.

Suntharalingam M, Wente SR (2003) Peering through the pore: nuclear pore complex structure, assembly, and function. Dev Cell 4(6):775–789PubMed

93.

Thurner B, Roder C, Dieckmann D, Heuer M, Kruse M, Glaser A, Keikavoussi P, Kampgen E, Bender A, Schuler G (1999) Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods 223(1):1–15PubMed

94.

Toka FN, Suvas S, Rouse BT (2004) CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against Herpes simplex virus type 1. J Virol 78(23):13082–13089PubMed

95.

Twist CJ, Beier DR, Disteche CM, Edelhoff S, Tedder TF (1998) The mouse Cd83 gene: structure, domain organization, and chromosome localization. Immunogenetics 48(6):383–393PubMed

96.

Vicente-Manzanares M, Sancho D, Yanez-Mo M, Sanchez-Madrid F (2002) The leukocyte cytoskeleton in cell migration and immune interactions. Int Rev Cytol 216:233–289PubMedCrossRef

97.

Vinciguerra P, Stutz F (2004) mRNA export: an assembly line from genes to nuclear pores. Curr Opin Cell Biol 16(3):285–292PubMed

98.

Weissman D, Li Y, Ananworanich J, Zhou LJ, Adelsberger J, Tedder TF, Baseler M, Fauci AS (1995) Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. Proc Natl Acad Sci USA 92(3):826–830PubMed

99.

Wilflingseder D, Mullauer B, Schramek H, Banki Z, Pruenster M, Dierich MP, Stoiber H (2004) HIV-1-induced migration of monocyte-derived dendritic cells is associated with differential activation of MAPK pathways. J Immunol 173(12):7497–7505PubMed

100.

Wilson GM, Brewer G (1999) Identification and characterization of proteins binding A + U-rich elements. Methods 17(1):74–83PubMed

101.

Wilusz CJ, Wormington M, Peltz SW (2001) The cap-to-tail guide to mRNA turnover. Nat Rev Mol Cell Biol 2(4):237–246PubMed

102.

Wolenski M, Cramer SO, Ehrlich S, Steeg C, Fleischer B, von Bonin A (2003) Enhanced activation of CD83-positive T cells. Scand J Immunol 58(3):306–311PubMed

103.

Yang S, Yang Y, Raycraft J, Zhang H, Kanan S, Guo Y, Ronai Z, Hellstrom I, Hellstrom KE (2004) Melanoma cells transfected to express CD83 induce antitumor immunity that can be increased by also engaging CD137. Proc Natl Acad Sci 101(14):4990–4995PubMed

104.

Zhou LJ, Schwarting R, Smith HM, Tedder TF (1992) A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J Immunol 149(2):735–742PubMed

105.

Zhou LJ, Tedder TF (1996) CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci USA 93(6):2588–2592PubMed

106.

Zhou LJ, Tedder TF (1995) Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol 154(8):3821–3835PubMed

107.

Zhou LJ, Tedder TF (1995) A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. Blood 86(9):3295–3301PubMed

108.

Zinser E, Lechmann M, Golka A, Hock B, Steinkasserer A (2006) Determination of the inhibitory activity and biological half-live of soluble CD83: comparison of wild type and mutant isoforms. Immunobiology 211(6–8):449–453PubMed

109.

Zinser E, Lechmann M, Golka A, Lutz MB, Steinkasserer A (2004) Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83. J Exp Med 200(3):345–351PubMed

110.

Zinser E, Turza N, Steinkasserer A (2004) CNI-1493 mediated suppression of dendritic cell activation in vitro and in vivo. Immunobiology 209(1–2):89–97PubMed

Title: CD83: an update on functions and prospects of the maturation marker of dendritic cells
Authors: Alexander T. Prechtel
Alexander Steinkasserer
Publication date: 01-05-2007
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 2/2007
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-007-0743-z

At a glance: The STEP trials

Springer Medicine

CD83: an update on functions and prospects of the maturation marker of dendritic cells

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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