Top

Published in:

01-05-2007 | Short Communication

Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease

Authors: Yasutoshi Hida, Yoshiaki Kubo, Kazutoshi Murao, Seiji Arase

Published in: Archives of Dermatological Research | Issue 2/2007

Abstract

The class III histone deacetylase (HDAC), SIRT1, is a mammalian homologue of the Saccharomyces cerevisiae chromatin-silencing factor Sir2 that regulates longevity. SIRT1 regulates cell survival via deacetylation of p53 and forkhead transcription factors, and overexpression of SIRT1 is reported to be essential for cell growth and survival in some kinds of cancer. To elucidate the role of SIRT1 in human skin carcinogenesis, we have examined SIRT1 protein expression in 20 cases each of squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Bowen’s disease (BD), and actinic keratosis (AK) by immunohistochemical analysis. Overexpression of SIRT1 is frequently observed in all kinds of non-melanoma skin cancers included in this study. In particular, strong expression was observed in all cases of BD. In addition, no obvious difference between AK and SCC was observed in the expression of SIRT1, suggesting that overexpression of SIRT1 may have some relevance to the early stage of skin carcinogenesis. We suppose that SIRT1 could be one of the critical targets for future therapy with the aim of inhibiting cell proliferation and promoting apoptosis in non-melanoma skin cancers.

Brasanac D, Boricic I, Todorovic V, Tomanovic N, Radojevic S (2005) Cyclin A and β-catenin expression in actinic keratosis, Bowen’s disease and invasive squamous cell carcinoma of the skin. Br J Dermatol 153:1166–1175PubMedCrossRef

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng H-L, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011–2015PubMedCrossRef

Chen WY, Wang DH, Yen RWC, Luo J, Gu W, Baylin SB (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123:437–448PubMedCrossRef

Ford J, Jiang M, Milner J (2005) Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 65:10457–10463PubMedCrossRef

Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, DePinho RA, Gu Y, Simon JA, Bedalov A (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66:4368–4377PubMedCrossRef

Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795–800PubMedCrossRef

Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A, Ouyang X, Brockdorff N, Abate-Shen C, Farnham P, Reinberg D (2005) Composition and histone substrate of polycomb repressive group complexes change during cellular differentiation. PNAS 102:1859–1864PubMedCrossRef

Lim CS (2006) SIRT1: tumor promoter or suppressor? Med Hypotheses 67:341–344PubMedCrossRef

Longo VD, Kennedy BK (2006) Sirtuins in aging and age-related disease. Cell 126:257–268PubMedCrossRef

10.

Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116:551–563PubMedCrossRef

11.

Murao K, Kubo Y, Fukuhara K, Matsumoto K, Arase S (2005) Three cases of Bowen’s disease on the lower abdomen associated with high-risk types 16, 33, and 59 of human papillomavirus. J Am Acad Dermatol 52:723–724PubMedCrossRef

12.

Murao K, Kubo Y, Takiwaki H, Arase S, Matsumoto K (2005) Bowen’s disease on the sole: p16^INK4a overexpression associated with human papillomavirus type 16. Br J Dermatol 152:170–173PubMedCrossRef

13.

Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M, Kozaki K, Akishita M, Ouchi Y, Kaneki M (2006) SIRT1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25:176–185PubMed

14.

Salama ME, Mahmood MN, Qureshi HS, Ma C, Zarbo RJ, Ormsby AH (2003) Dermatopathology p16^INK4aexpression in actinic keratosis and Bowen’s disease. Br J Dermatol 149:1006–1012PubMedCrossRef

15.

Sherr CJ, McCormick F (2002) The RB and p53 pathways in cancer. Cancer Cell 2:103–112PubMedCrossRef

16.

Vaziri H, Dessain SK, Eaton EN, Imai S-I, Frye RA, Pandita TK, Guarente L, Weinberg RA (2001) hSIR2^SIRT1 function as an NAD-dependent p53 deacetylase. Cell 107:149–159PubMedCrossRef

17.

Voelter-Mahlknecht S, Mahlknecht U (2006) Cloning, chromosomal characterization and maping of the NAD-dependent histone deacetylases gene sirtuin 1. Int J Mol Med 17:59–67PubMed

18.

Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J (2006) Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nature Cell Biol 8:1025–1031PubMedCrossRef

19.

Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (2004) Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. ENBO J 23:2369–2380

Title: Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
Authors: Yasutoshi Hida
Yoshiaki Kubo
Kazutoshi Murao
Seiji Arase
Publication date: 01-05-2007
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 2/2007
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-006-0725-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2007

Study of substance P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus

CD83: an update on functions and prospects of the maturation marker of dendritic cells

Activation of PKCδ and p38δ MAPK during okadaic acid dependent keratinocyte apoptosis

Antifungal susceptibility testing of Trichophyton rubrum by E-test

UVB activation of NF-κB in normal human keratinocytes occurs via a unique mechanism

Role of PKC-delta as a signal mediator in epidermal barrier homeostasis