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01-05-2007 | News and Views

Role of PKC-delta as a signal mediator in epidermal barrier homeostasis

Authors: Bong Kyun Ahn, Se Kyoo Jeong, Seung Hun Lee

Published in: Archives of Dermatological Research | Issue 2/2007

Abstract

The skin shows an important “epidermal permeability barrier homeostasis” in response to barrier disruption. Calcium ion (Ca²⁺), a major regulator in keratinocyte differentiation and proliferation, plays a crucial role in skin barrier homeostasis. Acute barrier disruption induces an immediate depletion of both extra- and intracellular calcium ions in the epidermis, especially in the upper granular layers, and results in the loss of normal epidermal calcium gradient. Currently, we hypothesize that the change in the intracellular calcium ion concentration triggers the barrier repair responses, such as lamellar body (LB) secretion and increased lipid synthesis in the epidermis. In this article, we suggest that PKC-delta is a signaling mediator for the changes in extracellular and intracellular calcium ion concentration.

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Title: Role of PKC-delta as a signal mediator in epidermal barrier homeostasis
Authors: Bong Kyun Ahn
Se Kyoo Jeong
Seung Hun Lee
Publication date: 01-05-2007
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 2/2007
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-007-0738-9

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Role of PKC-delta as a signal mediator in epidermal barrier homeostasis

Abstract

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