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International Orthopaedics
Published in: International Orthopaedics 4/2010

01-04-2010 | Original Paper

The regenerative effect of platelet-rich plasma on healing in large osteochondral defects

Authors: Y. Sun, Y. Feng, C. Q. Zhang, S. B. Chen, X. G. Cheng

Published in: International Orthopaedics | Issue 4/2010

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Abstract

Platelet-rich plasma (PRP), a platelet concentrate made of autogenous blood, has been used to improve bone and soft tissue defect healing in recent years. The aim of this study was to assess the effect of PRP on articular cartilage defects in a rabbit model. Forty-eight osteochondral defects created in the femoropatellar groove were (a) left untreated, (b) treated with autogenous PRP in a poly-lactic-glycolic acid (PLGA), or (c) with PLGA alone. Platelets were enriched 5.12-fold compared to normal blood in the PRP. After four and 12 weeks, the explanted tissue specimens were assessed by macroscopic examination, micro-computed tomography, and histological evaluation. Macroscopic examination, micro-computed tomography and histology of the newly formed cartilage and bone in the defect differ significantly between the PRP-treated and the untreated groups, and stimulatory effect of PRP on osteochondral formation was observed. In conclusion, PRP in PLGA improves osteochondral healing in a rabbit model.
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Metadata
Title
The regenerative effect of platelet-rich plasma on healing in large osteochondral defects
Authors
Y. Sun
Y. Feng
C. Q. Zhang
S. B. Chen
X. G. Cheng
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 4/2010
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-009-0793-2

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