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Open Access 01-01-2021 | Optic Neuritis | Correspondence

MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis

Authors: Brigitte Wildemann, Sven Jarius, Jonas Franz, Klemens Ruprecht, Markus Reindl, Christine Stadelmann

Published in: Acta Neuropathologica | Issue 1/2021

Excerpt

A paraneoplastic etiology has been reported in few patients with aquaporin-4 (AQP4)-IgG-seropositive neuromyelitis optica spectrum disorders (NMOSD), with lung and breast cancer being the most frequent associated malignancies [12]. Whether MOG encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease [MOGAD]), a rare autoimmune disease characterized by serum immunoglobulin G antibodies (IgG) against myelin oligodendrocyte glycoprotein (MOG) and overlapping clinical and radiological features with both NMOSD and multiple sclerosis (MS) [4‐7, 11], may occur in a paraneoplastic context is less well known. We report on a patient with oligosymptomatic MOG-EM emerging several months after detection and resection of an ovarian teratoma. Histopathology revealed neural tissue expressing MOG protein and accompanying immune cell infiltration within the teratoma, suggesting a possible paraneoplastic origin of MOG-EM in this case. …

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Title: MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis
Authors: Brigitte Wildemann
Sven Jarius
Jonas Franz
Klemens Ruprecht
Markus Reindl
Christine Stadelmann
Publication date: 01-01-2021
Publisher: Springer Berlin Heidelberg
Keywords: Optic Neuritis
Neuromyelitis Optica Spectrum Disease
Published in: Acta Neuropathologica / Issue 1/2021
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-020-02236-5

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MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis

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