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01-01-2021 | Glioblastoma | Correspondence

Malignant transformation of a polymorphous low grade neuroepithelial tumor of the young (PLNTY)

Authors: Tejus A. Bale, Sameer F. Sait, Jamal Benhamida, Ryan Ptashkin, Sofia Haque, Liliana Villafania, Martin Sill, Justyna Sadowska, Razia B. Akhtar, Benjamin Liechty, Rupa Juthani, Marc Ladanyi, Mary Fowkes, Matthias A. Karajannis, Marc K. Rosenblum

Published in: Acta Neuropathologica | Issue 1/2021

Excerpt

PLNTY comprise an indolent group of tumors in children and young adults harboring MAPK pathway alterations [2, 5, 6] including FGFR3-TACC3 fusions, which also characterize a subset of glioblastomas [1]. To date, there have been no reports of aggressive behavior and malignant transformation in tumors meeting diagnostic criteria for PLNTY. Here, we present a pediatric patient diagnosed with PLNTY with FGFR3-TACC3 fusion, who experienced recurrent glioblastoma-like disease within < 18 months. …

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Title: Malignant transformation of a polymorphous low grade neuroepithelial tumor of the young (PLNTY)
Authors: Tejus A. Bale
Sameer F. Sait
Jamal Benhamida
Ryan Ptashkin
Sofia Haque
Liliana Villafania
Martin Sill
Justyna Sadowska
Razia B. Akhtar
Benjamin Liechty
Rupa Juthani
Marc Ladanyi
Mary Fowkes
Matthias A. Karajannis
Marc K. Rosenblum
Publication date: 01-01-2021
Publisher: Springer Berlin Heidelberg
Keywords: Glioblastoma
Glioma
Glioma
Glioblastoma
Glioblastoma
Glioma
Published in: Acta Neuropathologica / Issue 1/2021
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-020-02245-4

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Malignant transformation of a polymorphous low grade neuroepithelial tumor of the young (PLNTY)

Excerpt

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Excerpt

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