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Open Access 01-08-2019 | Glioblastoma | Correspondence

Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas

Authors: Katharina Filipski, Yannick Braun, Jenny Zinke, Bastian Roller, Peter Baumgarten, Marlies Wagner, Christian Senft, Pia S. Zeiner, Michael W. Ronellenfitsch, Joachim P. Steinbach, Karl H. Plate, Gilles Gasparoni, Michel Mittelbronn, David Capper, Patrick N. Harter

Published in: Acta Neuropathologica | Issue 2/2019

Excerpt

The current World Health Organisation (WHO) Classification of Central Nervous System Tumours defines oligodendrogliomas by IDH mutation and 1p/19q codeletion [12]. Oligodendrogliomas differ from diffuse astrocytomas regarding genetic alterations in telomere maintenance mechanisms by frequently displaying TERT promoter mutations while astrocytomas typically exhibit ATRX (a-thalassaemia/mental retardation syndrome X-linked) mutations leading to alternative lengthening of telomeres (ALT) [1, 2, 7, 10, 13]. The distinction between both glioma types is crucial since it has a considerable impact on both patient treatment and outcome. …

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Title: Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas
Authors: Katharina Filipski
Yannick Braun
Jenny Zinke
Bastian Roller
Peter Baumgarten
Marlies Wagner
Christian Senft
Pia S. Zeiner
Michael W. Ronellenfitsch
Joachim P. Steinbach
Karl H. Plate
Gilles Gasparoni
Michel Mittelbronn
David Capper
Patrick N. Harter
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Keywords: Glioblastoma
Astrocytoma
Glioma
Glioma
Astrocytoma
Glioblastoma
Astrocytoma
Glioblastoma
Oligodendroglioma
Glioma
Published in: Acta Neuropathologica / Issue 2/2019
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-019-02025-9

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