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Open Access 01-03-2022 | Insulins | Original Contribution

A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study

Authors: Alejandro Villasanta-Gonzalez, Juan Francisco Alcala-Diaz, Cristina Vals-Delgado, Antonio Pablo Arenas, Magdalena P. Cardelo, Juan Luis Romero-Cabrera, Fernando Rodriguez-Cantalejo, Javier Delgado-Lista, Maria M. Malagon, Pablo Perez-Martinez, Matthias B. Schulze, Antonio Camargo, Jose Lopez-Miranda

Published in: European Journal of Nutrition | Issue 2/2022

Abstract

Purpose

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We aimed to identify a plasma fatty acid (FA) profile associated with T2DM development.

Methods

We included 462 coronary heart disease patients from the CORDIOPREV study without T2DM at baseline. Of these, 107 patients developed T2DM according to the American Diabetes Association (ADA) diagnosis criteria after a median follow-up of 60 months. We performed a random classification of patients in a training set, used to build a FA Score, and a Validation set, in which we tested the FA Score.

Results

FA selection with the highest prediction power was performed by random survival forest in the Training set, which yielded 4 out of the 24 FA: myristic, petroselinic, α-linolenic and arachidonic acids. We built a FA Score with the selected FA and observed that patients with a higher score presented a greater risk of T2DM development, with an HR of 3.15 (95% CI 2.04–3.37) in the Training set, and an HR of 2.14 (95% CI 1.50–2.84) in the Validation set, per standard deviation (SD) increase. Moreover, patients with a higher FA Score presented lower insulin sensitivity and higher hepatic insulin resistance (p < 0.05).

Conclusion

Our results suggest that a detrimental FA plasma profile precedes the development of T2DM in patients with coronary heart disease, and that this FA profile can, therefore, be used as a predictive biomarker.

Clinical Trials.gov.Identifier

NCT00924937.

Available only for authorised users

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Title: A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study
Authors: Alejandro Villasanta-Gonzalez
Juan Francisco Alcala-Diaz
Cristina Vals-Delgado
Antonio Pablo Arenas
Magdalena P. Cardelo
Juan Luis Romero-Cabrera
Fernando Rodriguez-Cantalejo
Javier Delgado-Lista
Maria M. Malagon
Pablo Perez-Martinez
Matthias B. Schulze
Antonio Camargo
Jose Lopez-Miranda
Publication date: 01-03-2022
Publisher: Springer Berlin Heidelberg
Keywords: Insulins
Insulins
Type 2 Diabetes
Published in: European Journal of Nutrition / Issue 2/2022
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-021-02676-z

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