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01-06-2020 | Insulins | Review

Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials

Authors: Ana F. Raimundo, Filipa Félix, Rita Andrade, María-Teresa García-Conesa, Antonio González-Sarrías, João Gilsa-Lopes, Dulce do Ó, Ana Raimundo, Rogério Ribeiro, Ana Rodriguez-Mateos, Cláudia N. Santos, Manuel Schär, Ana Silva, Inês Cruz, Brian Wang, Paula Pinto, Regina Menezes

Published in: European Journal of Nutrition | Issue 4/2020

Abstract

Purpose

(Poly)phenols have been reported to confer protective effects against type 2 diabetes but the precise association remains elusive. This meta-analysis aimed to assess the effects of (poly)phenol intake on well-established biomarkers in people with type 2 diabetes or at risk of developing diabetes.

Methods

A systematic search was conducted using the following selection criteria: (1) human randomized controlled trials involving individuals with prediabetes and type 2 diabetes; (2) one or more of the following biomarkers: glucose, glycated haemoglobin (HbA1c), insulin, pro-insulin, homeostatic model assessment of insulin resistance (HOMA-IR), islet amyloid polypeptide (IAPP)/amylin, pro-IAPP/pro-amylin, glucagon, C-peptide; (3) chronic intervention with pure or enriched mixtures of (poly)phenols. From 488 references, 88 were assessed for eligibility; data were extracted from 27 studies and 20 were used for meta-analysis. The groups included in the meta-analysis were: (poly)phenol mixtures, isoflavones, flavanols, anthocyanins and resveratrol.

Results

Estimated intervention/control mean differences evidenced that, overall, the consumption of (poly)phenols contributed to reduced fasting glucose levels (− 3.32 mg/dL; 95% CI − 5.86, − 0.77; P = 0.011). Hb1Ac was only slightly reduced (− 0.24%; 95% CI − 0.43, − 0.044; P = 0.016) whereas the levels of insulin and HOMA-IR were not altered. Subgroup comparative analyses indicated a stronger effect on blood glucose in individuals with diabetes (− 5.86 mg/dL, 95% CI − 11.34, − 0.39; P = 0.036) and this effect was even stronger in individuals taking anti-diabetic medication (− 10.17 mg/dL, 95% CI − 16.59, − 3.75; P = 0.002).

Conclusions

Our results support that the consumption of (poly)phenols may contribute to lower glucose levels in individuals with type 2 diabetes or at risk of diabetes and that these compounds may also act in combination with anti-diabetic drugs.

The total number of studies is equal to 21 because one of the studies depicts results from 2 interventions (a (poly)phenol mixture and resveratrol).

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Title: Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials
Authors: Ana F. Raimundo
Filipa Félix
Rita Andrade
María-Teresa García-Conesa
Antonio González-Sarrías
João Gilsa-Lopes
Dulce do Ó
Ana Raimundo
Rogério Ribeiro
Ana Rodriguez-Mateos
Cláudia N. Santos
Manuel Schär
Ana Silva
Inês Cruz
Brian Wang
Paula Pinto
Regina Menezes
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Insulins
Insulins
Type 2 Diabetes
Published in: European Journal of Nutrition / Issue 4/2020
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-020-02189-1

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Abstract

Purpose

Methods

Results

Conclusions

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