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01-10-2018 | Original Contribution

Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain?

Authors: Susanna E. Hanvold, Kathrine J. Vinknes, Nasser E. Bastani, Cheryl Turner, Elin B. Løken, Tom Mala, Helga Refsum, Anne-Marie Aas

Published in: European Journal of Nutrition | Issue 7/2018

Abstract

Purpose

Plasma concentrations of several amino acids (AAs) are positively correlated with obesity. The aim of this study was to examine if selected plasma AAs are associated with weight regain from 2 to 4 years after Roux-en-Y gastric bypass (RYGB).

Methods

In a prospective study with 165 patients, we examined the relationship between plasma aromatic AAs (AAAs), branched chain AAs (BCAAs), and total cysteine (tCys) 2 years after RYGB, with BMI at 2 years and with weight change from 2 to 4 years after surgery. Analyses were adjusted for relevant covariates.

Result

The investigated AAs at 2 years correlated positively with BMI at 2 years (P ≤ 0.003 for all). BCAAs and AAAs at 2 years correlated inversely with % weight loss from 0 to 2 years (P = 0.002 and P = 0.001, respectively), while the association was not significant for tCys (r = −0.14, P = 0.08). Plasma tCys at 2 years correlated positively with BMI at 4 years (P = 0.010) and with weight regain from 2 to 4 years (P = 0.015).

Conclusion

Plasma AAAs, BCAAs, and tCys at 2 years were associated with BMI at 2 years. In addition, plasma AAAs and BCAAs at 2 years were associated with weight loss from 0 to 2 years, while tCys at 2 years was associated with weight regain from 2 to 4 years after RYGB. These results suggest that high tCys at 2 years may be used as a prognostic marker for future weight regain. The study was registered in ClinicalTrials.gov (NCT0 1270451).

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Title: Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain?
Authors: Susanna E. Hanvold
Kathrine J. Vinknes
Nasser E. Bastani
Cheryl Turner
Elin B. Løken
Tom Mala
Helga Refsum
Anne-Marie Aas
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 7/2018
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-017-1533-9

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Conclusion

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