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European Journal of Nutrition

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Open Access 01-03-2018 | Original Contribution

l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation

Authors: Daniel Menzel, Hermann Haller, Manfred Wilhelm, Horst Robenek

Published in: European Journal of Nutrition | Issue 2/2018

Abstract

Purpose

The aim of this trial was to investigate the influence of a dietetic product consisting of a unique combination of l-arginine with the vitamins B₆, folic acid and B₁₂ (Telcor^® Arginin plus) on endothelial dysfunction.

Methods

Subjects aged 40–65 years with mild to moderate blood pressure (BP) elevation not treated with anti-hypertensive drugs were randomly assigned to either the dietetic product (n = 40) or a matching placebo (n = 41) for 3 months with open follow-up for a further 3 months. Postprandial change in endothelial function was assessed using the validated reactive hyperaemia index (RHI) at 3 months compared to the study onset (RHI post–pre, visit 3–visit 1; ΔΔRHI). Secondary parameters included BP and plasma homocysteine concentration.

Results

The primary efficacy analysis revealed superiority of the nutritional intervention over placebo (p = 0.0349) in reducing the deterioration of endothelial function. While in the active group ΔΔRHI increased (0.371 ± 0.122), almost no change could be detected in the placebo group (0.031 ± 0.100), thus demonstrating a significant improvement in vascular function in the intervention group. Moreover, the intervention reduced BP and homocysteine levels. Non-serious adverse events were equally distributed in both groups, and none of the events were assessed as possibly intervention-related by the investigators.

Conclusions

This trial confirmed the effective and safe use of dietary management with l-arginine in combination with B vitamins. The primary efficacy analysis demonstrated a statistically significant superiority of the combination of l-arginine with B vitamins over placebo in improving and restoring impaired endothelial function and lowering BP in patients with mild to moderate blood pressure elevation.

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Title: l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation
Authors: Daniel Menzel
Hermann Haller
Manfred Wilhelm
Horst Robenek
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 2/2018
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1342-6

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