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European Journal of Nutrition

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01-04-2017 | Original Contribution

Effects of vitamin D supplementation on endothelial function: a systematic review and meta-analysis of randomised clinical trials

Authors: Azizah Mat Hussin, Ammar W. Ashor, Inez Schoenmakers, Tom Hill, John C. Mathers, Mario Siervo

Published in: European Journal of Nutrition | Issue 3/2017

Abstract

Background

In addition to regulating calcium homoeostasis and bone health, vitamin D influences vascular and metabolic processes including endothelial function (EF) and insulin signalling. This systematic review and meta-analysis of randomised clinical trials (RCTs) were conducted to investigate the effect of vitamin D supplementation on EF and to examine whether the effect size was modified by health status, study duration, dose, route of vitamin D administration, vitamin D status (baseline and post-intervention), body mass index (BMI), age and type of vitamin D.

Methods

We searched the Medline, Embase, Cochrane Library and Scopus databases from inception until March 2015 for studies meeting the following criteria: (1) RCT with adult participants, (2) vitamin D administration alone, (3) studies that quantified EF using commonly applied methods including ultrasound, plethysmography, applanation tonometry and laser Doppler.

Results

Sixteen articles reporting data for 1177 participants were included. Study duration ranged from 4 to 52 weeks. The effect of vitamin D on EF was not significant (SMD: 0.08, 95 % CI −0.06, 0.22, p = 0.28). Subgroup analysis showed a significant improvement of EF in diabetic subjects (SMD: 0.31, 95 % CI 0.05, 0.57, p = 0.02). A non-significant trend was found for diastolic blood pressure (β = 0.02; p = 0.07) and BMI (β = 0.05; p = 0.06).

Conclusions

Vitamin D supplementation did not improve EF. The significant effect of vitamin D in diabetics and a tendency for an association with BMI may indicate a role of excess adiposity and insulin resistance in modulating the effects of vitamin D on vascular function. This remains to be tested in future studies.

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Title: Effects of vitamin D supplementation on endothelial function: a systematic review and meta-analysis of randomised clinical trials
Authors: Azizah Mat Hussin
Ammar W. Ashor
Inez Schoenmakers
Tom Hill
John C. Mathers
Mario Siervo
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 3/2017
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1159-3

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Effects of vitamin D supplementation on endothelial function: a systematic review and meta-analysis of randomised clinical trials

Abstract

Background

Methods

Results

Conclusions

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Abstract

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