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01-12-2015 | Review

Advanced physiological roles of guanidinoacetic acid

Author: Sergej M. Ostojic

Published in: European Journal of Nutrition | Issue 8/2015

Abstract

Dietary guanidinoacetic acid (GAA) seems to improve cellular bioenergetics by stimulating creatine biosynthesis. However, GAA could have other biological functions that might affect its possible use as a food ingredient in human nutrition. In this paper, we identified several alternative physiological roles of supplemental GAA, including the stimulation of hormonal release and neuromodulation, an alteration of metabolic utilization of arginine, and an adjustment of oxidant–antioxidant status. A better knowledge of how GAA affects human physiology may facilitate its use as an experimental nutritional intervention for novel purposes and conditions.

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Title: Advanced physiological roles of guanidinoacetic acid
Author: Sergej M. Ostojic
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 8/2015
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-015-1050-7

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