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Published in: European Journal of Nutrition 4/2013

01-06-2013 | Original Contribution

Neonatal overfeeding causes higher adrenal catecholamine content and basal secretion and liver dysfunction in adult rats

Authors: E. P. S. Conceição, E. G. Moura, I. H. Trevenzoli, N. Peixoto-Silva, C. R. Pinheiro, V. Younes-Rapozo, E. Oliveira, P. C. Lisboa

Published in: European Journal of Nutrition | Issue 4/2013

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Abstract

Purpose

Rats that are overfed during lactation exhibit neonatal hyperleptinemia and higher visceral adiposity, hypertension, higher liver oxidative stress and insulin resistance in the liver as adults. Previously, we demonstrated that neonatal hyperleptinemia is associated with adrenal medullary hyperfunction, hypertension and liver steatosis in adulthood. Therefore, we hypothesised that adrenal and liver functions are altered in adult obese rats that were overfed during lactation, which would underlie their hypertension and liver alterations.

Methods

The litter size was reduced from ten to three male pups on the third day of lactation until weaning (SL) to induce early overfeeding in Wistar rats. The control group had ten rats per litter (NL). Rats had free access to standard diet, and water after weaning until the rats were 180 days old.

Results

The SL group exhibited higher adrenal catecholamine content (absolute: +35% and relative: +40%), tyrosine hydroxylase (+31%) and DOPA decarboxylase (+90%) protein contents and basal catecholamine secretion in vitro (+57%). However, the hormones of the hypothalamic-pituitary-adrenal cortex axis were unchanged. β3-adrenergic receptor content in visceral adipose tissue was unchanged in SL rats, but the β2-adrenergic receptor content in the liver was lower in this group (−45%). The SL group exhibited higher glycogen and triglycerides contents in the liver (+79 and +49%, respectively), which suggested microesteatosis.

Conclusions

Neonatal overfeeding led to higher adrenomedullary function, but the liver β2-adrenergic receptor content was reduced. These results may contribute to the hepatic dysfunction characteristic of liver obesity complications.
Literature
1.
go back to reference Barker DJ (2004) The developmental origins of adult disease. J Am Coll Nutr 23:588S–595S Barker DJ (2004) The developmental origins of adult disease. J Am Coll Nutr 23:588S–595S
2.
go back to reference de Moura EG, Lisboa PC, Passos MC (2008) Neonatal programming of neuroimmunomodulation–role of adipocytokines and neuropeptides. NeuroImmunoModulation 15:176–188CrossRef de Moura EG, Lisboa PC, Passos MC (2008) Neonatal programming of neuroimmunomodulation–role of adipocytokines and neuropeptides. NeuroImmunoModulation 15:176–188CrossRef
3.
go back to reference Gluckman PD, Hanson MA (2007) Developmental plasticity and human disease: research directions. J Intern Med 261:461–471CrossRef Gluckman PD, Hanson MA (2007) Developmental plasticity and human disease: research directions. J Intern Med 261:461–471CrossRef
4.
go back to reference Plagemann A, Harder T, Rake A, Voits M, Fink H, Rohde W, Dörner G (1999) Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res 836:146–155CrossRef Plagemann A, Harder T, Rake A, Voits M, Fink H, Rohde W, Dörner G (1999) Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res 836:146–155CrossRef
5.
go back to reference Rodrigues AL, de Moura EG, Passos MC, Dutra SC, Lisboa PC (2009) Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic-pituitary-thyroid axis of young and adult rats. J Physiol 587:2647–2661CrossRef Rodrigues AL, de Moura EG, Passos MC, Dutra SC, Lisboa PC (2009) Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic-pituitary-thyroid axis of young and adult rats. J Physiol 587:2647–2661CrossRef
6.
go back to reference Plagemann A, Harder T, Rake A, Waas T, Melchior K, Ziska T, Rohde W, Dörner G (1999) Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats. J Neuroendocrinol 7:541–546 Plagemann A, Harder T, Rake A, Waas T, Melchior K, Ziska T, Rohde W, Dörner G (1999) Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats. J Neuroendocrinol 7:541–546
7.
go back to reference Davidowa H, Plagemann A (2000) Decreased inhibition by leptin of hypothalamic arcuate neurons in neonatally overfed young rats. NeuroReport 21:2795–2798CrossRef Davidowa H, Plagemann A (2000) Decreased inhibition by leptin of hypothalamic arcuate neurons in neonatally overfed young rats. NeuroReport 21:2795–2798CrossRef
8.
go back to reference Davidowa H, Plagemann A (2001) Inhibition by insulin of hypothalamic VMN neurons in rats overweight due to postnatal overfeeding. NeuroReport 29:3201–3204CrossRef Davidowa H, Plagemann A (2001) Inhibition by insulin of hypothalamic VMN neurons in rats overweight due to postnatal overfeeding. NeuroReport 29:3201–3204CrossRef
9.
go back to reference Rodrigues AL, de Moura EG, Passos MC, Trevenzoli IH, da Conceição EP, Bonono IT, Neto JF, Lisboa PC (2011) Postnatal early overfeeding induces hypothalamic higher SOCS3 expression and lower STAT3 activity in adult rats. J Nutr Biochem 22:109–117CrossRef Rodrigues AL, de Moura EG, Passos MC, Trevenzoli IH, da Conceição EP, Bonono IT, Neto JF, Lisboa PC (2011) Postnatal early overfeeding induces hypothalamic higher SOCS3 expression and lower STAT3 activity in adult rats. J Nutr Biochem 22:109–117CrossRef
10.
go back to reference Ferretti S, Fornari A, Pedrazzi P, Pellegrini M, Zoli M (2011) Developmental overfeeding alters hypothalamic neuropeptide mRNA levels and response to a high-fat diet in adult mice. Peptides 32:1371–1383CrossRef Ferretti S, Fornari A, Pedrazzi P, Pellegrini M, Zoli M (2011) Developmental overfeeding alters hypothalamic neuropeptide mRNA levels and response to a high-fat diet in adult mice. Peptides 32:1371–1383CrossRef
11.
go back to reference Reilly JJ, Kelly J (2011) Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes (Lond) 35:891–898CrossRef Reilly JJ, Kelly J (2011) Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes (Lond) 35:891–898CrossRef
12.
go back to reference Trevenzoli IH, Valle MM, Machado FB, Garcia RM, Passos MC, Lisboa PC, Moura EG (2007) Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters. J Physiol 580:629–637CrossRef Trevenzoli IH, Valle MM, Machado FB, Garcia RM, Passos MC, Lisboa PC, Moura EG (2007) Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters. J Physiol 580:629–637CrossRef
13.
go back to reference Trevenzoli IH, Rodrigues AL, Oliveira E, Thole AA, Carvalho L, Figueiredo MS, Toste FP, Neto JF, Passos MC, Lisboa PC et al (2010) Leptin treatment during lactation programs leptin synthesis, intermediate metabolism, and liver microsteatosis in adult rats. Horm Metab Res 42:483–490CrossRef Trevenzoli IH, Rodrigues AL, Oliveira E, Thole AA, Carvalho L, Figueiredo MS, Toste FP, Neto JF, Passos MC, Lisboa PC et al (2010) Leptin treatment during lactation programs leptin synthesis, intermediate metabolism, and liver microsteatosis in adult rats. Horm Metab Res 42:483–490CrossRef
14.
go back to reference Young JB (2002) Effects of litter size on sympathetic activity in young adult rats. Am J Physiol Regul Integr Comp Physiol 282:1113–1121 Young JB (2002) Effects of litter size on sympathetic activity in young adult rats. Am J Physiol Regul Integr Comp Physiol 282:1113–1121
15.
go back to reference Plagemann A, Heidrich I, Götz F, Rohde W, Dörner G (1992) Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding. Exp Clin Endocrinol 99:154–158CrossRef Plagemann A, Heidrich I, Götz F, Rohde W, Dörner G (1992) Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding. Exp Clin Endocrinol 99:154–158CrossRef
16.
go back to reference Peng YX, Shan J, Qi XY, Zhang SJ, Ma SP, Wang N, Li JP, Xue H, Wu M (2006) The catecholamine-beta-adrenoreceptor-cAMP system and prediction of cardiovascular events in hypertension. Clin Exp Pharmacol Physiol 33:227–231CrossRef Peng YX, Shan J, Qi XY, Zhang SJ, Ma SP, Wang N, Li JP, Xue H, Wu M (2006) The catecholamine-beta-adrenoreceptor-cAMP system and prediction of cardiovascular events in hypertension. Clin Exp Pharmacol Physiol 33:227–231CrossRef
17.
go back to reference Conceição EPS, Franco JG, Oliveira E, Resende AC, Amaral TAS, Peixoto-Silva N, Passos MCF, Moura EG, Lisboa PC (2012) Oxidative stress programming in a rat model of postnatal early overnutrition—role of insulin resistance. J Nutr Biochem. doi:10.1016/j.jnutbio.2012.02.010 Conceição EPS, Franco JG, Oliveira E, Resende AC, Amaral TAS, Peixoto-Silva N, Passos MCF, Moura EG, Lisboa PC (2012) Oxidative stress programming in a rat model of postnatal early overnutrition—role of insulin resistance. J Nutr Biochem. doi:10.​1016/​j.​jnutbio.​2012.​02.​010
18.
go back to reference Nonogaki K (2000) New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 43:533–549CrossRef Nonogaki K (2000) New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 43:533–549CrossRef
19.
go back to reference Blaak EE, van Baak MA, Kempen KPG, Saris WHM (1993) Role of α- and β-adrenoceptors in sympathetically mediated thermogenesis. Am J Physiol 264:E11–E17 Blaak EE, van Baak MA, Kempen KPG, Saris WHM (1993) Role of α- and β-adrenoceptors in sympathetically mediated thermogenesis. Am J Physiol 264:E11–E17
20.
go back to reference Yorek MA, Rufo GA Jr, Ray PD (1980) Gluconeogenesis in rabbit liver. III. The influences of glucagon, epinephrine, alpha- and beta-adrenergic agents on gluconeogenesis in isolated hepatocytes. Biochim Biophys Acta 632:517–526CrossRef Yorek MA, Rufo GA Jr, Ray PD (1980) Gluconeogenesis in rabbit liver. III. The influences of glucagon, epinephrine, alpha- and beta-adrenergic agents on gluconeogenesis in isolated hepatocytes. Biochim Biophys Acta 632:517–526CrossRef
21.
go back to reference Djouder N, Tuerk RD, Suter M, Salvioni P, Thali RF, Scholz R, Vaahtomeri K, Auchli Y, Rechsteiner H, Brunisholz RA et al (2010) PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J 29:469–481CrossRef Djouder N, Tuerk RD, Suter M, Salvioni P, Thali RF, Scholz R, Vaahtomeri K, Auchli Y, Rechsteiner H, Brunisholz RA et al (2010) PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J 29:469–481CrossRef
22.
go back to reference Campbell JE, Peckett AJ, D’souza AM, Hawke TJ, Riddell MC (2011) Adipogenic and lipolytic effects of chronic glucocorticoid exposure. Am J Physiol 300:198–209CrossRef Campbell JE, Peckett AJ, D’souza AM, Hawke TJ, Riddell MC (2011) Adipogenic and lipolytic effects of chronic glucocorticoid exposure. Am J Physiol 300:198–209CrossRef
23.
go back to reference Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM (1990) Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary cultures. J Neurosci 10:520–530 Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM (1990) Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary cultures. J Neurosci 10:520–530
24.
go back to reference Cornett LE, Hiller FC, Jacobi SE, Cao W, McGraw DW (1998) Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene. Mol Pharmacol 54:1016–1023 Cornett LE, Hiller FC, Jacobi SE, Cao W, McGraw DW (1998) Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene. Mol Pharmacol 54:1016–1023
25.
go back to reference Pasquali R, Cantobelli S, Casimirri F, Capelli M, Bortoluzzi L, Flamia R, Labate AMM, Barabara L (1993) The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77:341–346CrossRef Pasquali R, Cantobelli S, Casimirri F, Capelli M, Bortoluzzi L, Flamia R, Labate AMM, Barabara L (1993) The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77:341–346CrossRef
26.
go back to reference Mastorakos G, Zapanti E (2004) The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin releasing hormone. Nutr Neurosci 7:271–280CrossRef Mastorakos G, Zapanti E (2004) The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin releasing hormone. Nutr Neurosci 7:271–280CrossRef
27.
go back to reference Boullu-Ciocca S, Dutour A, Guillaume V, Achard V, Oliver C, Grino M (2005) Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome. Diabetes 54:197–203CrossRef Boullu-Ciocca S, Dutour A, Guillaume V, Achard V, Oliver C, Grino M (2005) Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome. Diabetes 54:197–203CrossRef
28.
go back to reference Spencer SJ, Tilbrook A (2009) Neonatal overfeeding alters adult anxiety and stress responsiveness. Psychoneuroendocrinology 34:1133–1143CrossRef Spencer SJ, Tilbrook A (2009) Neonatal overfeeding alters adult anxiety and stress responsiveness. Psychoneuroendocrinology 34:1133–1143CrossRef
29.
go back to reference Kahan E, Rosen M (1984) The influence of litter size and favourable conditions on mortality and weaning weights in rats. Lab Anim 18:247–251CrossRef Kahan E, Rosen M (1984) The influence of litter size and favourable conditions on mortality and weaning weights in rats. Lab Anim 18:247–251CrossRef
30.
go back to reference Scherle W (1970) A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26:57–60 Scherle W (1970) A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26:57–60
31.
go back to reference Yin FCP, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG (1982) Use of tibial length to quantify cardiac hypertrophy: application in the ageing rat. Am J Physiol 243:H941–H947 Yin FCP, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG (1982) Use of tibial length to quantify cardiac hypertrophy: application in the ageing rat. Am J Physiol 243:H941–H947
32.
go back to reference Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, New York Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, New York
33.
go back to reference Trevenzoli IH, Pinheiro CR, Conceição EPS, Oliveira E, Passos MCF, Lisboa PC, Moura EG (2010) Programming of rat adrenal medulla by neonatal hyperleptinemia: adrenal morphology, catecholamine secretion, and leptin signaling pathway. Am J Physiol Endocrinol Metab 298:941–949CrossRef Trevenzoli IH, Pinheiro CR, Conceição EPS, Oliveira E, Passos MCF, Lisboa PC, Moura EG (2010) Programming of rat adrenal medulla by neonatal hyperleptinemia: adrenal morphology, catecholamine secretion, and leptin signaling pathway. Am J Physiol Endocrinol Metab 298:941–949CrossRef
34.
go back to reference Oliveira E, Pinheiro CR, Santos-Silva AP, Trevenzoli IH, Abreu-Villaça Y, Nogueira Neto JF, Reis AM, Passos MC, Moura EG, Lisboa PC (2010) Nicotine exposure affects mother’s and pup’s nutritional, biochemical, and hormonal profiles during lactation in rats. J Endocrinol 205:159–170CrossRef Oliveira E, Pinheiro CR, Santos-Silva AP, Trevenzoli IH, Abreu-Villaça Y, Nogueira Neto JF, Reis AM, Passos MC, Moura EG, Lisboa PC (2010) Nicotine exposure affects mother’s and pup’s nutritional, biochemical, and hormonal profiles during lactation in rats. J Endocrinol 205:159–170CrossRef
35.
go back to reference Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497–509 Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497–509
36.
go back to reference Catta-Preta M, Mendonca LS, Fraulob-Aquino J, Aguila MB, Mandarim-de-Lacerda CA (2011) A critical analysis of three quantitative methods of assessment of hepatic steatosis in liver biopsies. Virchows Arch 459:477–485CrossRef Catta-Preta M, Mendonca LS, Fraulob-Aquino J, Aguila MB, Mandarim-de-Lacerda CA (2011) A critical analysis of three quantitative methods of assessment of hepatic steatosis in liver biopsies. Virchows Arch 459:477–485CrossRef
37.
go back to reference Bancroft JD, Stevens A (1990) Theory and practice of histological techniques. Churchill Livingstone, Edinburgh Bancroft JD, Stevens A (1990) Theory and practice of histological techniques. Churchill Livingstone, Edinburgh
38.
go back to reference Conceição EPS, Trevenzoli IH, Oliveira E, Franco JG, Carlos AS, Nascimento-Saba CC, Moura EG, Lisboa PC (2011) Higher white adipocyte area and lower leptin production in adult rats overfed during lactation. Horm Metab Res 43:513–516CrossRef Conceição EPS, Trevenzoli IH, Oliveira E, Franco JG, Carlos AS, Nascimento-Saba CC, Moura EG, Lisboa PC (2011) Higher white adipocyte area and lower leptin production in adult rats overfed during lactation. Horm Metab Res 43:513–516CrossRef
39.
go back to reference Plagemann A, Roepke K, Harder T, Brunn M, Harder A, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K, Dudenhausen JW (2010) Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding. J Perinat Med 38:393–400 Plagemann A, Roepke K, Harder T, Brunn M, Harder A, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K, Dudenhausen JW (2010) Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding. J Perinat Med 38:393–400
40.
go back to reference Shah NS, Lila A (2011) Childhood cushing disease: a challenge in diagnosis and management. Horm Res Paediatr 76:65–70CrossRef Shah NS, Lila A (2011) Childhood cushing disease: a challenge in diagnosis and management. Horm Res Paediatr 76:65–70CrossRef
41.
go back to reference Rosmond R, Dallman MF, Björntorp P (1998) Stress-related cortisol secretion in men: relationship with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 83:1853–1859CrossRef Rosmond R, Dallman MF, Björntorp P (1998) Stress-related cortisol secretion in men: relationship with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 83:1853–1859CrossRef
42.
go back to reference Salehi M, Ferenczi A, Zumoff B (2005) Obesity and cortisol status. Horm Metab Res 37:193–197CrossRef Salehi M, Ferenczi A, Zumoff B (2005) Obesity and cortisol status. Horm Metab Res 37:193–197CrossRef
43.
go back to reference Velkoska E, Cole TJ, Morris MJ (2005) Early dietary intervention: long-term effects on blood pressure, brain neuropeptide Y, and adiposity markers. Am J Physiol Endocrinol Metab 288:1236–1243CrossRef Velkoska E, Cole TJ, Morris MJ (2005) Early dietary intervention: long-term effects on blood pressure, brain neuropeptide Y, and adiposity markers. Am J Physiol Endocrinol Metab 288:1236–1243CrossRef
44.
go back to reference Edgerton DS, Basu R, Ramnanan CJ, Farmer TD, Neal D, Scott M, Jacobson P, Rizza RA, Cherrington AD (2010) Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab 298:1019–1026CrossRef Edgerton DS, Basu R, Ramnanan CJ, Farmer TD, Neal D, Scott M, Jacobson P, Rizza RA, Cherrington AD (2010) Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab 298:1019–1026CrossRef
45.
go back to reference Perelló M, Moreno G, Gaillard RC, Spinedi E (2004) Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. Neuro Endocrinol Lett 25(1–2):119–126 Perelló M, Moreno G, Gaillard RC, Spinedi E (2004) Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. Neuro Endocrinol Lett 25(1–2):119–126
46.
go back to reference Tokuyama K, Himms-Hagen J (1989) Adrenalectomy prevents obesity in glutamate-treated mice. Am J Physiol 257(2 Pt 1):E139–E144 Tokuyama K, Himms-Hagen J (1989) Adrenalectomy prevents obesity in glutamate-treated mice. Am J Physiol 257(2 Pt 1):E139–E144
47.
go back to reference Auvinen HE, Romijn JA, Biermasz NR, Havekes LM, Smit JW, Rensen PC, Pereira AM (2011) Effects of high fat diet on the Basal activity of the hypothalamus-pituitary-adrenal axis in mice: a systematic review. Horm Metab Res 43(13):899–906CrossRef Auvinen HE, Romijn JA, Biermasz NR, Havekes LM, Smit JW, Rensen PC, Pereira AM (2011) Effects of high fat diet on the Basal activity of the hypothalamus-pituitary-adrenal axis in mice: a systematic review. Horm Metab Res 43(13):899–906CrossRef
48.
go back to reference Auvinen HE, Romijn JA, Biermasz NR, Pijl H, Havekes LM, Smit JW, Rensen PC, Pereira AM (2012) The effects of high fat diet on the basal activity of the hypothalamus-pituitary-adrenal axis in mice. J Endocrinol 214(2):191–197CrossRef Auvinen HE, Romijn JA, Biermasz NR, Pijl H, Havekes LM, Smit JW, Rensen PC, Pereira AM (2012) The effects of high fat diet on the basal activity of the hypothalamus-pituitary-adrenal axis in mice. J Endocrinol 214(2):191–197CrossRef
49.
go back to reference Martins AC, Souza KL, Shio MT, Mathias PC, Lelkes PI, Garcia RM (2004) Adrenal medullary function and expression of catecholamine-synthesising enzymes in mice with hypothalamic obesity. Life Sci 74(26):3211–3222CrossRef Martins AC, Souza KL, Shio MT, Mathias PC, Lelkes PI, Garcia RM (2004) Adrenal medullary function and expression of catecholamine-synthesising enzymes in mice with hypothalamic obesity. Life Sci 74(26):3211–3222CrossRef
50.
go back to reference Collins S, Daniel KW, Rohlfs EM (1999) Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. Int J Obes Relat Metab Disord 23:669–677CrossRef Collins S, Daniel KW, Rohlfs EM (1999) Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. Int J Obes Relat Metab Disord 23:669–677CrossRef
51.
go back to reference Xu XF, Björntorp P (1990) Effects of dexamethasone on multiplication and differentiation of rat adipose precursor cells. Exp Cell Res 189:247–252CrossRef Xu XF, Björntorp P (1990) Effects of dexamethasone on multiplication and differentiation of rat adipose precursor cells. Exp Cell Res 189:247–252CrossRef
52.
go back to reference Fried SK, Russell CD, Grauso NL, Brolin RE (1993) Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissue of obese women and men. J Clin Invest 92:2191–2198CrossRef Fried SK, Russell CD, Grauso NL, Brolin RE (1993) Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissue of obese women and men. J Clin Invest 92:2191–2198CrossRef
53.
go back to reference Raddatz D, Ramadori G (2007) Carbohydrate metabolism and the liver: actual aspects from physiology and disease. Z Gastroenterol 45:51–62CrossRef Raddatz D, Ramadori G (2007) Carbohydrate metabolism and the liver: actual aspects from physiology and disease. Z Gastroenterol 45:51–62CrossRef
54.
go back to reference Li J, Huang J, Li JS, Chen H, Huang K, Zheng L (2011) Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. J Hepatol PMID: 22173165 Li J, Huang J, Li JS, Chen H, Huang K, Zheng L (2011) Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. J Hepatol PMID: 22173165
55.
go back to reference Dudley KJ, Sloboda DM, Connor KL, Beltrand J, Vickers MH (2011) Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation. PLoS ONE 6:e21662CrossRef Dudley KJ, Sloboda DM, Connor KL, Beltrand J, Vickers MH (2011) Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation. PLoS ONE 6:e21662CrossRef
56.
go back to reference Hodis J, Kutinová-Canová N, Potmesil P, Kameníková L, Kmonícková E, Zídek Z, Farghali H (2007) The role of adrenergic agonists on glycogenolysis in rat hepatocyte cultures and possible involvement of NO. Phys Res 56:419–425 Hodis J, Kutinová-Canová N, Potmesil P, Kameníková L, Kmonícková E, Zídek Z, Farghali H (2007) The role of adrenergic agonists on glycogenolysis in rat hepatocyte cultures and possible involvement of NO. Phys Res 56:419–425
57.
go back to reference Chakrabarti S, Guria S, Samanta I, Das M (2007) Thyroid dysfunction modulates glucoregulatory mechanism in rat. Indian J Exp Biol 45:549–553 Chakrabarti S, Guria S, Samanta I, Das M (2007) Thyroid dysfunction modulates glucoregulatory mechanism in rat. Indian J Exp Biol 45:549–553
58.
go back to reference Hou M, Liu Y, Zhu L, Sun B, Guo M, Burén J, Li X (2011) Neonatal overfeeding induced by small litter rearing causes altered glucocorticoid metabolism in rats. PLoS ONE 6:e25726CrossRef Hou M, Liu Y, Zhu L, Sun B, Guo M, Burén J, Li X (2011) Neonatal overfeeding induced by small litter rearing causes altered glucocorticoid metabolism in rats. PLoS ONE 6:e25726CrossRef
59.
go back to reference Baudrand R, Domínguez JM, Carvajal CA, Riquelme A, Campino C, Macchiavello S, Bozinovic M, Morales M, Pizarro M, Solis N et al (2011) Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients. Metabolism 60:1775–1780CrossRef Baudrand R, Domínguez JM, Carvajal CA, Riquelme A, Campino C, Macchiavello S, Bozinovic M, Morales M, Pizarro M, Solis N et al (2011) Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients. Metabolism 60:1775–1780CrossRef
60.
go back to reference Duff DA, Snell K (1982) Effect of altered neonatal nutrition on the development of enzymes of lipid and carbohydrate metabolism in the rat. J Nutr 112:1057–1066 Duff DA, Snell K (1982) Effect of altered neonatal nutrition on the development of enzymes of lipid and carbohydrate metabolism in the rat. J Nutr 112:1057–1066
61.
go back to reference Jakobsen MU, Berentzen T, Sørensen TI, Overvad K (2007) Abdominal obesity and fatty liver. Epidemiol Rev 29:77–87CrossRef Jakobsen MU, Berentzen T, Sørensen TI, Overvad K (2007) Abdominal obesity and fatty liver. Epidemiol Rev 29:77–87CrossRef
62.
go back to reference Pietiläinen KH, Rissanen A, Kaprio J, Mäkimattila S, Häkkinen AM, Westerbacka J, Sutinen J, Vehkavaara S, Yki-Järvinen H (2005) Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. Am J Phys Metab 288:768–774 Pietiläinen KH, Rissanen A, Kaprio J, Mäkimattila S, Häkkinen AM, Westerbacka J, Sutinen J, Vehkavaara S, Yki-Järvinen H (2005) Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. Am J Phys Metab 288:768–774
63.
go back to reference Oben JA, Mouralidarane A, Samuelsson AM, Matthews PJ, Morgan ML, McKee C, Soeda J, Fernandez-Twinn DS, Martin-Gronert MS, Ozanne SE et al (2010) Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol 52:913–920CrossRef Oben JA, Mouralidarane A, Samuelsson AM, Matthews PJ, Morgan ML, McKee C, Soeda J, Fernandez-Twinn DS, Martin-Gronert MS, Ozanne SE et al (2010) Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol 52:913–920CrossRef
64.
go back to reference Bouanane S, Merzouk H, Benkalfat NB, Soulimane N, Merzouk SA, Gresti J, Tessier C, Narce M (2010) Hepatic and very low-density lipoprotein fatty acids in obese offspring of overfed dams. Metabolism 59:1701–1709CrossRef Bouanane S, Merzouk H, Benkalfat NB, Soulimane N, Merzouk SA, Gresti J, Tessier C, Narce M (2010) Hepatic and very low-density lipoprotein fatty acids in obese offspring of overfed dams. Metabolism 59:1701–1709CrossRef
Metadata
Title
Neonatal overfeeding causes higher adrenal catecholamine content and basal secretion and liver dysfunction in adult rats
Authors
E. P. S. Conceição
E. G. Moura
I. H. Trevenzoli
N. Peixoto-Silva
C. R. Pinheiro
V. Younes-Rapozo
E. Oliveira
P. C. Lisboa
Publication date
01-06-2013
Publisher
Springer-Verlag
Published in
European Journal of Nutrition / Issue 4/2013
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-012-0448-8

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