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Published in: Clinical Research in Cardiology 9/2021

01-09-2021 | Cardiogenic Shock | Critical Perspective

New challenges in cardiac intensive care units

Authors: Enzo Lüsebrink, Antonia Kellnar, Clemens Scherer, Kathrin Krieg, Mathias Orban, Tobias Petzold, Sven Peterss, Stefan Kääb, Stefan Brunner, Daniel Braun, Christian Hagl, Jörg Hausleiter, Steffen Massberg, Martin Orban

Published in: Clinical Research in Cardiology | Issue 9/2021

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Abstract

Critical care cardiology is a steadily and rapidly developing sub-specialization within cardiovascular medicine, since the first emergence of a coronary care unit in the early 1960s. Today, modern cardiac intensive care units (CICU) serve a complex patient population with a high burden of cardiovascular and non-cardiovascular critical illnesses. Treatment of these patients requires a multidisciplinary approach, with a combination of highly specialized knowledge and skills in cardiovascular diseases, as well as emergency, critical-care and internal medicine. The CICU has always posed special challenges to both experienced intensivists as well as fellows-in-training (FIT) and is certainly one of the most demanding training phases. In recent years, these challenges have grown significantly owing to technological innovations, with new and steadily rising numbers of complex interventional procedures and new options for temporary circulatory support for critically ill patients, such as venoarterial extracorporeal membrane oxygenation (VA-ECMO). Herein, we focus on the successful CICU management of these special patient cohorts, which must become an integral part of critical-care training.
Literature
1.
go back to reference Morrow DA, Fang JC, Fintel DJ, Granger CB, Katz JN, Kushner FG, Kuvin JT, Lopez-Sendon J, McAreavey D, Nallamothu B, Page RL 2nd, Parrillo JE, Peterson PN, Winkelman C, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Clinical Cardiology, Council on Cardiovascular Nursing, and Council on Quality of Care and Outcomes Research (2012) Evolution of critical care cardiology: transformation of the cardiovascular intensive care unit and the emerging need for new medical staffing and training models: a scientific statement from the American Heart Association. Circulation 126:1408–1428. https://doi.org/10.1161/CIR.0b013e31826890b0CrossRefPubMed Morrow DA, Fang JC, Fintel DJ, Granger CB, Katz JN, Kushner FG, Kuvin JT, Lopez-Sendon J, McAreavey D, Nallamothu B, Page RL 2nd, Parrillo JE, Peterson PN, Winkelman C, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Clinical Cardiology, Council on Cardiovascular Nursing, and Council on Quality of Care and Outcomes Research (2012) Evolution of critical care cardiology: transformation of the cardiovascular intensive care unit and the emerging need for new medical staffing and training models: a scientific statement from the American Heart Association. Circulation 126:1408–1428. https://​doi.​org/​10.​1161/​CIR.​0b013e31826890b0​CrossRefPubMed
11.
go back to reference Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Brown DL, Block PC, Guyton RA, Pichard AD, Bavaria JE, Herrmann HC, Douglas PS, Petersen JL, Akin JJ, Anderson WN, Wang D, Pocock S, PARTNER Trial Investigators (2010) Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363:1597–1607. https://doi.org/10.1056/NEJMoa1008232CrossRefPubMed Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Brown DL, Block PC, Guyton RA, Pichard AD, Bavaria JE, Herrmann HC, Douglas PS, Petersen JL, Akin JJ, Anderson WN, Wang D, Pocock S, PARTNER Trial Investigators (2010) Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363:1597–1607. https://​doi.​org/​10.​1056/​NEJMoa1008232CrossRefPubMed
13.
go back to reference Amat-Santos IJ, Messika-Zeitoun D, Eltchaninoff H, Kapadia S, Lerakis S, Cheema AN, Gutiérrez-Ibanes E, Munoz-Garcia AJ, Pan M, Webb JG, Herrmann HC, Kodali S, Nombela-Franco L, Tamburino C, Jilaihawi H, Masson JB, de Jr Brito FS, Ferreira MC, Lima VC, Mangione JA, Iung B, Vahanian A, Durand E, Tuzcu EM, Hayek SS, Angulo-Llanos R, Gómez-Doblas JJ, Castillo JC, Dvir D, Leon MB, Garcia E, Cobiella J, Vilacosta I, Barbanti M, Makkar R, Ribeiro HB, Urena M, Dumont E, Pibarot P, Lopez J, San Roman A, Rodés-Cabau J (2015) Infective endocarditis after transcatheter aortic valve implantation: results from a large multicenter registry. Circulation 131:1566–1574. https://doi.org/10.1161/CIRCULATIONAHA.114.014089CrossRefPubMed Amat-Santos IJ, Messika-Zeitoun D, Eltchaninoff H, Kapadia S, Lerakis S, Cheema AN, Gutiérrez-Ibanes E, Munoz-Garcia AJ, Pan M, Webb JG, Herrmann HC, Kodali S, Nombela-Franco L, Tamburino C, Jilaihawi H, Masson JB, de Jr Brito FS, Ferreira MC, Lima VC, Mangione JA, Iung B, Vahanian A, Durand E, Tuzcu EM, Hayek SS, Angulo-Llanos R, Gómez-Doblas JJ, Castillo JC, Dvir D, Leon MB, Garcia E, Cobiella J, Vilacosta I, Barbanti M, Makkar R, Ribeiro HB, Urena M, Dumont E, Pibarot P, Lopez J, San Roman A, Rodés-Cabau J (2015) Infective endocarditis after transcatheter aortic valve implantation: results from a large multicenter registry. Circulation 131:1566–1574. https://​doi.​org/​10.​1161/​CIRCULATIONAHA.​114.​014089CrossRefPubMed
15.
go back to reference Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL, ESC Scientific Document Group (2015) 2015 ESC Guidelines for the management of infective endocarditis: the Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 36:3075–3128. https://doi.org/10.1093/eurheartj/ehv319CrossRefPubMed Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL, ESC Scientific Document Group (2015) 2015 ESC Guidelines for the management of infective endocarditis: the Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 36:3075–3128. https://​doi.​org/​10.​1093/​eurheartj/​ehv319CrossRefPubMed
16.
go back to reference Hamm CW, Möllmann H, Holzhey D, Beckmann A, Veit C, Figulla HR, Cremer J, Kuck KH, Lange R, Zahn R, Sack S, Schuler G, Walther T, Beyersdorf F, Böhm M, Heusch G, Funkat AK, Meinertz T, Neumann T, Papoutsis K, Schneider S, Welz A, Mohr FW, GARY-Executive Board (2014) The German Aortic Valve Registry (GARY): in-hospital outcome. Eur Heart J 35:1588–1598. https://doi.org/10.1093/eurheartj/eht381CrossRefPubMed Hamm CW, Möllmann H, Holzhey D, Beckmann A, Veit C, Figulla HR, Cremer J, Kuck KH, Lange R, Zahn R, Sack S, Schuler G, Walther T, Beyersdorf F, Böhm M, Heusch G, Funkat AK, Meinertz T, Neumann T, Papoutsis K, Schneider S, Welz A, Mohr FW, GARY-Executive Board (2014) The German Aortic Valve Registry (GARY): in-hospital outcome. Eur Heart J 35:1588–1598. https://​doi.​org/​10.​1093/​eurheartj/​eht381CrossRefPubMed
18.
go back to reference Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R, American College of Critical Care Medicine (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 41:263–306. https://doi.org/10.1097/CCM.0b013e3182783b72CrossRefPubMed Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R, American College of Critical Care Medicine (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 41:263–306. https://​doi.​org/​10.​1097/​CCM.​0b013e3182783b72​CrossRefPubMed
19.
20.
go back to reference Scherer C, Lüsebrink E, Kupka D, Stocker TJ, Stark K, Stremmel C, Orban M, Petzold T, Germayer A, Mauthe K, Kääb S, Mehilli J, Braun D, Theiss H, Brunner S, Hausleiter J, Massberg S, Orban M (2020) Long-term clinical outcome of cardiogenic shock patients undergoing Impella CP treatment vs. standard of care. J Clin Med. 9:3803. https://doi.org/10.3390/jcm9123803CrossRefPubMedCentral Scherer C, Lüsebrink E, Kupka D, Stocker TJ, Stark K, Stremmel C, Orban M, Petzold T, Germayer A, Mauthe K, Kääb S, Mehilli J, Braun D, Theiss H, Brunner S, Hausleiter J, Massberg S, Orban M (2020) Long-term clinical outcome of cardiogenic shock patients undergoing Impella CP treatment vs. standard of care. J Clin Med. 9:3803. https://​doi.​org/​10.​3390/​jcm9123803CrossRefPubMedCentral
21.
go back to reference Baran DA, Grines CL, Bailey S, Burkhoff D, Hall SA, Henry TD, Hollenberg SM, Kapur NK, O’Neill W, Ornato JP, Stelling K, Thiele H, van Diepen S, Naidu SS (2019) SCAI clinical expert consensus statement on the classification of cardiogenic shock: this document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019. Catheter Cardiovasc Interv 94:29–37. https://doi.org/10.1002/ccd.28329CrossRefPubMed Baran DA, Grines CL, Bailey S, Burkhoff D, Hall SA, Henry TD, Hollenberg SM, Kapur NK, O’Neill W, Ornato JP, Stelling K, Thiele H, van Diepen S, Naidu SS (2019) SCAI clinical expert consensus statement on the classification of cardiogenic shock: this document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019. Catheter Cardiovasc Interv 94:29–37. https://​doi.​org/​10.​1002/​ccd.​28329CrossRefPubMed
23.
go back to reference Werdan K, Boeken U, Briegel MJ, Buerke M, Geppert A, Janssens U, Kelm M, Michels G, Pilarczyk K, Schlitt A, Thiele H, Willems S, Zeymer U, Zwißler B, Delle-Karth G, Ferrari M, Figulla H, Heller A, Hindricks G, Pichler-Cetin E, Pieske BM, Prondzinsky R, Thielmann M, Bauersachs J, Kopp I, Ruß M (2021) Kurzversion der 2. Auflage der deutsch-österreichischen S3-Leitlinie “Infarkt-bedingter Kardiogener Schock—diagnose, monitoring und therapie.” Anaesthesist. 70:42–70. https://doi.org/10.1007/s00101-020-00868-6CrossRefPubMed Werdan K, Boeken U, Briegel MJ, Buerke M, Geppert A, Janssens U, Kelm M, Michels G, Pilarczyk K, Schlitt A, Thiele H, Willems S, Zeymer U, Zwißler B, Delle-Karth G, Ferrari M, Figulla H, Heller A, Hindricks G, Pichler-Cetin E, Pieske BM, Prondzinsky R, Thielmann M, Bauersachs J, Kopp I, Ruß M (2021) Kurzversion der 2. Auflage der deutsch-österreichischen S3-Leitlinie “Infarkt-bedingter Kardiogener Schock—diagnose, monitoring und therapie.” Anaesthesist. 70:42–70. https://​doi.​org/​10.​1007/​s00101-020-00868-6CrossRefPubMed
24.
go back to reference Orban M, Mayer K, Morath T, Bernlochner I, Hadamitzky M, Braun S, Schulz S, Hoppmann P, Hausleiter J, Tiroch K, Mehilli J, Schunkert H, Massberg S, Laugwitz KL, Sibbing D, Kastrati A (2014) Prasugrel vs clopidogrel in cardiogenic shock patients undergoing primary PCI for acute myocardial infarction. Results of the ISAR-SHOCK registry. Thromb Haemost 112:1190–1197. https://doi.org/10.1160/TH14-06-0489CrossRefPubMed Orban M, Mayer K, Morath T, Bernlochner I, Hadamitzky M, Braun S, Schulz S, Hoppmann P, Hausleiter J, Tiroch K, Mehilli J, Schunkert H, Massberg S, Laugwitz KL, Sibbing D, Kastrati A (2014) Prasugrel vs clopidogrel in cardiogenic shock patients undergoing primary PCI for acute myocardial infarction. Results of the ISAR-SHOCK registry. Thromb Haemost 112:1190–1197. https://​doi.​org/​10.​1160/​TH14-06-0489CrossRefPubMed
25.
go back to reference Thiele H, Akin I, Sandri M, Fuernau G, de Waha S, Meyer-Saraei R, Nordbeck P, Geisler T, Landmesser U, Skurk C, Fach A, Lapp H, Piek JJ, Noc M, Goslar T, Felix SB, Maier LS, Stepinska J, Oldroyd K, Serpytis P, Montalescot G, Barthelemy O, Huber K, Windecker S, Savonitto S, Torremante P, Vrints C, Schneider S, Desch S, Zeymer U, CULPRIT-SHOCK Investigators (2017) PCI strategies in patients with acute myocardial infarction and cardiogenic shock. N Engl J Med 377:2419–2432. https://doi.org/10.1056/NEJMoa1710261CrossRefPubMed Thiele H, Akin I, Sandri M, Fuernau G, de Waha S, Meyer-Saraei R, Nordbeck P, Geisler T, Landmesser U, Skurk C, Fach A, Lapp H, Piek JJ, Noc M, Goslar T, Felix SB, Maier LS, Stepinska J, Oldroyd K, Serpytis P, Montalescot G, Barthelemy O, Huber K, Windecker S, Savonitto S, Torremante P, Vrints C, Schneider S, Desch S, Zeymer U, CULPRIT-SHOCK Investigators (2017) PCI strategies in patients with acute myocardial infarction and cardiogenic shock. N Engl J Med 377:2419–2432. https://​doi.​org/​10.​1056/​NEJMoa1710261CrossRefPubMed
26.
go back to reference Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J, CRICS-TRIGGERSEP Group (2019) Targeted temperature management for cardiac arrest with nonshockable rhythm. N Engl J Med. 381:2327–2337. https://doi.org/10.1056/NEJMoa1906661CrossRefPubMed Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J, CRICS-TRIGGERSEP Group (2019) Targeted temperature management for cardiac arrest with nonshockable rhythm. N Engl J Med. 381:2327–2337. https://​doi.​org/​10.​1056/​NEJMoa1906661CrossRefPubMed
27.
28.
go back to reference Rihal CS, Naidu SS, Givertz MM, Szeto WY, Burke JA, Kapur NK, Kern M, Garratt KN, Goldstein JA, Dimas V, Tu T (2015) 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus statement on the use of percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care: endorsed by the American Heart Association, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencion; Affirmation of Value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie d’intervention. J Am Coll Cardiol. 65:e7–e26. https://doi.org/10.1016/j.jacc.2015.03.036CrossRefPubMed Rihal CS, Naidu SS, Givertz MM, Szeto WY, Burke JA, Kapur NK, Kern M, Garratt KN, Goldstein JA, Dimas V, Tu T (2015) 2015 SCAI/ACC/HFSA/STS Clinical Expert Consensus statement on the use of percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care: endorsed by the American Heart Association, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencion; Affirmation of Value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie d’intervention. J Am Coll Cardiol. 65:e7–e26. https://​doi.​org/​10.​1016/​j.​jacc.​2015.​03.​036CrossRefPubMed
31.
36.
37.
go back to reference Schäfer A, Werner N, Westenfeld R, Møller JE, Schulze PC, Karatolios K, Pappalardo F, Maly J, Staudacher D, Lebreton G, Delmas C, Hunziker P, Fritzenwanger M, Napp LC, Ferrari M, Tarantini G (2019) Clinical scenarios for use of transvalvular microaxial pumps in acute heart failure and cardiogenic shock—a European experienced users working group opinion. Int J Cardiol 291:96–104. https://doi.org/10.1016/j.ijcard.2019.05.044CrossRefPubMed Schäfer A, Werner N, Westenfeld R, Møller JE, Schulze PC, Karatolios K, Pappalardo F, Maly J, Staudacher D, Lebreton G, Delmas C, Hunziker P, Fritzenwanger M, Napp LC, Ferrari M, Tarantini G (2019) Clinical scenarios for use of transvalvular microaxial pumps in acute heart failure and cardiogenic shock—a European experienced users working group opinion. Int J Cardiol 291:96–104. https://​doi.​org/​10.​1016/​j.​ijcard.​2019.​05.​044CrossRefPubMed
40.
go back to reference ELSO Guidelines for Cardiopulmonary Extracorporeal Life Support Extracorporeal Life Support Organization, Version 1.4 August 2017 Ann Arbor, www.elso.org ELSO Guidelines for Cardiopulmonary Extracorporeal Life Support Extracorporeal Life Support Organization, Version 1.4 August 2017 Ann Arbor, www.​elso.​org
44.
go back to reference Schrage B, Becher PM, Bernhardt A, Bezerra H, Blankenberg S, Brunner S, Colson P, Cudemus Deseda G, Dabboura S, Eckner D, Eden M, Eitel I, Frank D, Frey N, Funamoto M, Goßling A, Graf T, Hagl C, Kirchhof P, Kupka D, Landmesser U, Lipinski J, Lopes M, Majunke N, Maniuc O, McGrath D, Möbius-Winkler S, Morrow DA, Mourad M, Noel C, Nordbeck P, Orban M, Pappalardo F, Patel SM, Pauschinger M, Pazzanese V, Reichenspurner H, Sandri M, Schulze PC, Schwinger RHG, Sinning JM, Aksoy A, Skurk C, Szczanowicz L, Thiele H, Tietz F, Varshney A, Wechsler L, Westermann D (2020) Left ventricular unloading is associated with lower mortality in patients with cardiogenic shock treated with venoarterial extracorporeal membrane oxygenation: results from an international, multicenter cohort study. Circulation 142:2095–2106. https://doi.org/10.1161/CIRCULATIONAHA.120.048792CrossRefPubMedPubMedCentral Schrage B, Becher PM, Bernhardt A, Bezerra H, Blankenberg S, Brunner S, Colson P, Cudemus Deseda G, Dabboura S, Eckner D, Eden M, Eitel I, Frank D, Frey N, Funamoto M, Goßling A, Graf T, Hagl C, Kirchhof P, Kupka D, Landmesser U, Lipinski J, Lopes M, Majunke N, Maniuc O, McGrath D, Möbius-Winkler S, Morrow DA, Mourad M, Noel C, Nordbeck P, Orban M, Pappalardo F, Patel SM, Pauschinger M, Pazzanese V, Reichenspurner H, Sandri M, Schulze PC, Schwinger RHG, Sinning JM, Aksoy A, Skurk C, Szczanowicz L, Thiele H, Tietz F, Varshney A, Wechsler L, Westermann D (2020) Left ventricular unloading is associated with lower mortality in patients with cardiogenic shock treated with venoarterial extracorporeal membrane oxygenation: results from an international, multicenter cohort study. Circulation 142:2095–2106. https://​doi.​org/​10.​1161/​CIRCULATIONAHA.​120.​048792CrossRefPubMedPubMedCentral
45.
47.
go back to reference Banning AS, Adriaenssens T, Berry C, Bogaerts K, Erglis A, Distelmaier K, Guagliumi G, Haine S, Kastrati A, Massberg S, Orban M, Myrmel T, Vuylsteke A, Alfonso F, Van de Werf F, Verheugt F, Flather M, Sabaté M, Vrints C, Gershlick AH, Collaborators (2021) (2020) Veno-arterial extracorporeal membrane oxygenation (ECMO) in patients with cardiogenic shock: rationale and design of the randomised, multicentre, open-label EURO SHOCK trial. EuroIntervention 16:e1227–e1236. https://doi.org/10.4244/EIJ-D-20-01076CrossRef Banning AS, Adriaenssens T, Berry C, Bogaerts K, Erglis A, Distelmaier K, Guagliumi G, Haine S, Kastrati A, Massberg S, Orban M, Myrmel T, Vuylsteke A, Alfonso F, Van de Werf F, Verheugt F, Flather M, Sabaté M, Vrints C, Gershlick AH, Collaborators (2021) (2020) Veno-arterial extracorporeal membrane oxygenation (ECMO) in patients with cardiogenic shock: rationale and design of the randomised, multicentre, open-label EURO SHOCK trial. EuroIntervention 16:e1227–e1236. https://​doi.​org/​10.​4244/​EIJ-D-20-01076CrossRef
48.
go back to reference Thiele H, Freund A, Gimenez MR, de Waha-Thiele S, Akin I, Pöss J, Feistritzer HJ, Fuernau G, Graf T, Nef H, Hamm C, Böhm M, Lauten A, Schulze PC, Voigt I, Nordbeck P, Felix SB, Abel P, Baldus S, Laufs U, Lenk K, Landmesser U, Skurk C, Pieske B, Tschöpe C, Hennersdorf M, Wengenmayer T, Preusch M, Maier LS, Jung C, Kelm M, Clemmensen P, Westermann D, Seidler T, Schieffer B, Rassaf T, Mahabadi AA, Vasa-Nicotera M, Meincke F, Seyfarth M, Kersten A, Rottbauer W, Boekstegers P, Muellenbach R, Dengler T, Kadel C, Schempf B, Karagiannidis C, Hopf HB, Lehmann R, Bufe A, Baumanns S, Öner A, Linke A, Sedding D, Ferrari M, Bruch L, Goldmann B, John S, Möllmann H, Franz J, Lapp H, Lauten P, Noc M, Goslar T, Oerlecke I, Ouarrak T, Schneider S, Desch S, Zeymer U, ECLS-SHOCK Investigators (2021) Extracorporeal life support in patients with acute myocardial infarction complicated by cardiogenic shock—design and rationale of the ECLS-SHOCK trial. Am Heart J 234:1–11. https://doi.org/10.1016/j.ahj.2021.01.002CrossRefPubMed Thiele H, Freund A, Gimenez MR, de Waha-Thiele S, Akin I, Pöss J, Feistritzer HJ, Fuernau G, Graf T, Nef H, Hamm C, Böhm M, Lauten A, Schulze PC, Voigt I, Nordbeck P, Felix SB, Abel P, Baldus S, Laufs U, Lenk K, Landmesser U, Skurk C, Pieske B, Tschöpe C, Hennersdorf M, Wengenmayer T, Preusch M, Maier LS, Jung C, Kelm M, Clemmensen P, Westermann D, Seidler T, Schieffer B, Rassaf T, Mahabadi AA, Vasa-Nicotera M, Meincke F, Seyfarth M, Kersten A, Rottbauer W, Boekstegers P, Muellenbach R, Dengler T, Kadel C, Schempf B, Karagiannidis C, Hopf HB, Lehmann R, Bufe A, Baumanns S, Öner A, Linke A, Sedding D, Ferrari M, Bruch L, Goldmann B, John S, Möllmann H, Franz J, Lapp H, Lauten P, Noc M, Goslar T, Oerlecke I, Ouarrak T, Schneider S, Desch S, Zeymer U, ECLS-SHOCK Investigators (2021) Extracorporeal life support in patients with acute myocardial infarction complicated by cardiogenic shock—design and rationale of the ECLS-SHOCK trial. Am Heart J 234:1–11. https://​doi.​org/​10.​1016/​j.​ahj.​2021.​01.​002CrossRefPubMed
51.
go back to reference Kim F, Nichol G, Maynard C, Hallstrom A, Kudenchuk PJ, Rea T, Copass MK, Carlbom D, Deem S, Longstreth WT Jr, Olsufka M, Cobb LA (2014) Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial. JAMA 311:45–52. https://doi.org/10.1001/jama.2013.282173CrossRefPubMed Kim F, Nichol G, Maynard C, Hallstrom A, Kudenchuk PJ, Rea T, Copass MK, Carlbom D, Deem S, Longstreth WT Jr, Olsufka M, Cobb LA (2014) Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial. JAMA 311:45–52. https://​doi.​org/​10.​1001/​jama.​2013.​282173CrossRefPubMed
52.
go back to reference Nordberg P, Taccone FS, Truhlar A, Forsberg S, Hollenberg J, Jonsson M, Cuny J, Goldstein P, Vermeersch N, Higuet A, Jiménes FC, Ortiz FR, Williams J, Desruelles D, Creteur J, Dillenbeck E, Busche C, Busch HJ, Ringh M, Konrad D, Peterson J, Vincent JL, Svensson L (2019) Effect of trans-nasal evaporative intra-arrest cooling on functional neurologic outcome in out-of-hospital cardiac arrest: the PRINCESS randomized clinical trial. JAMA 321:1677–1685. https://doi.org/10.1001/jama.2019.4149CrossRefPubMedPubMedCentral Nordberg P, Taccone FS, Truhlar A, Forsberg S, Hollenberg J, Jonsson M, Cuny J, Goldstein P, Vermeersch N, Higuet A, Jiménes FC, Ortiz FR, Williams J, Desruelles D, Creteur J, Dillenbeck E, Busche C, Busch HJ, Ringh M, Konrad D, Peterson J, Vincent JL, Svensson L (2019) Effect of trans-nasal evaporative intra-arrest cooling on functional neurologic outcome in out-of-hospital cardiac arrest: the PRINCESS randomized clinical trial. JAMA 321:1677–1685. https://​doi.​org/​10.​1001/​jama.​2019.​4149CrossRefPubMedPubMedCentral
53.
go back to reference Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, TTM Trial Investigators (2013) Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 369:2197–2206. https://doi.org/10.1056/NEJMoa1310519CrossRefPubMed Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, TTM Trial Investigators (2013) Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 369:2197–2206. https://​doi.​org/​10.​1056/​NEJMoa1310519CrossRefPubMed
54.
go back to reference Lopez-de-Sa E, Juarez M, Armada E, Sanchez-Salado JC, Sanchez PL, Loma-Osorio P, Sionis A, Monedero MC, Martinez-Sellés M, Martín-Benitez JC, Ariza A, Uribarri A, Garcia-Acuña JM, Villa P, Perez PJ, Storm C, Dee A, Lopez-Sendon JL (2018) A multicentre randomized pilot trial on the effectiveness of different levels of cooling in comatose survivors of out-of-hospital cardiac arrest: the FROST-I trial. Intensive Care Med 44:1807–1815. https://doi.org/10.1007/s00134-018-5256-zCrossRefPubMed Lopez-de-Sa E, Juarez M, Armada E, Sanchez-Salado JC, Sanchez PL, Loma-Osorio P, Sionis A, Monedero MC, Martinez-Sellés M, Martín-Benitez JC, Ariza A, Uribarri A, Garcia-Acuña JM, Villa P, Perez PJ, Storm C, Dee A, Lopez-Sendon JL (2018) A multicentre randomized pilot trial on the effectiveness of different levels of cooling in comatose survivors of out-of-hospital cardiac arrest: the FROST-I trial. Intensive Care Med 44:1807–1815. https://​doi.​org/​10.​1007/​s00134-018-5256-zCrossRefPubMed
55.
go back to reference Kirkegaard H, Søreide E, de Haas I, Pettilä V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sørensen CA, Ilkjær S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hästbacka J, Laitio T, Skrifvars MB (2017) Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 318:341–350. https://doi.org/10.1001/jama.2017.8978CrossRefPubMedPubMedCentral Kirkegaard H, Søreide E, de Haas I, Pettilä V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sørensen CA, Ilkjær S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hästbacka J, Laitio T, Skrifvars MB (2017) Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 318:341–350. https://​doi.​org/​10.​1001/​jama.​2017.​8978CrossRefPubMedPubMedCentral
Metadata
Title
New challenges in cardiac intensive care units
Authors
Enzo Lüsebrink
Antonia Kellnar
Clemens Scherer
Kathrin Krieg
Mathias Orban
Tobias Petzold
Sven Peterss
Stefan Kääb
Stefan Brunner
Daniel Braun
Christian Hagl
Jörg Hausleiter
Steffen Massberg
Martin Orban
Publication date
01-09-2021
Publisher
Springer Berlin Heidelberg
Published in
Clinical Research in Cardiology / Issue 9/2021
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-021-01869-0

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