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01-12-2017 | Original Paper

Transcatheter aortic valve implantation in patients with a reduced left ventricular ejection fraction: a single-centre experience in 2000 patients (TAVIK Registry)

Authors: Gerhard Schymik, Panagiotis Tzamalis, Valentin Herzberger, Jens Bergmann, Peter Bramlage, Alexander Würth, Lars Oliver Conzelmann, Armin Luik, Holger Schröfel

Published in: Clinical Research in Cardiology | Issue 12/2017

Abstract

Background

Previous studies into the effect of a reduced left ventricular ejection fraction (EF) on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation (TAVI) have reported conflicting findings. We analysed data from the Karlsruhe TAVI registry with the aim of addressing this question.

Methods and results

Patients with aortic stenosis undergoing TAVI were divided into sub-groups according to EF: severely reduced (<30%; n = 109), reduced (≥30 and ≤40%; n = 201), and mid-range/preserved (>40%; n = 1690). VARC complications at 30 days for the population with severely reduced EF did not differ in comparison to the patients with mid-range/preserved EF. Patients with severely reduced EF had a significantly lower survival at 48 h (91.7 vs. 99.0%; p < 0.001), at 30 days (84.4 vs. 95.8%; p < 0.001) and at 1 year (66.1 vs. 85.0%, p < 0.001) compared to those with mid-range/preserved EF. The risk of death increased with age, peripheral arterial disease, poor self-care and chronic renal failure in patients with severely reduced EF.

Conclusions

Mortality post-TAVI was higher for patients with a reduced EF, although the excess comorbidity burden likely contributed to this. A reduced EF should not be considered a contraindication for TAVI per se, but the additional presence of comorbidity indicates increased risk for these patients.

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Title: Transcatheter aortic valve implantation in patients with a reduced left ventricular ejection fraction: a single-centre experience in 2000 patients (TAVIK Registry)
Authors: Gerhard Schymik
Panagiotis Tzamalis
Valentin Herzberger
Jens Bergmann
Peter Bramlage
Alexander Würth
Lars Oliver Conzelmann
Armin Luik
Holger Schröfel
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Research in Cardiology / Issue 12/2017
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-017-1151-9

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Transcatheter aortic valve implantation in patients with a reduced left ventricular ejection fraction: a single-centre experience in 2000 patients (TAVIK Registry)

Abstract

Background

Methods and results

Conclusions

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Abstract

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