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Published in: Clinical Research in Cardiology 5/2015

01-05-2015 | Review

Atrial fibrillation and long-term sports practice: epidemiology and mechanisms

Authors: S. Wernhart, M. Halle

Published in: Clinical Research in Cardiology | Issue 5/2015

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Abstract

Background

Lone atrial fibrillation (AF) is the most common arrhythmia of the heart and is considered to have a higher prevalence in athletes, especially in endurance sports.

Methods

We conducted an extensive literature research in pubmed using the key words s ports and atrial fibrillation.

Results

The majority of studies have methodological limitations due to different inclusion criteria, such as age, type of sport, training level as well as statistical bias. The inconsistency of data is reflected by the considerable range of AF occurrence, spanning from 0.3 to 12.8 %.

Conclusions

We consider it reasonable to separate a study population into sedentary individuals, leisure time sportsmen/women and elite athletes. A distinction between the categories may be achieved through a combination of exercise history, capacity (e.g. MET hours/week, e.g. VO2max) and competitive results. Since there is a large span in the analyzed age groups (24–84 years), we claim that the focus should be laid upon the 45- to 65-year-olds due to a sound detection rate of true positives. Finally, we discuss ways to increase the detection rate of paroxysmal AF and comment on new therapeutic options.
Literature
1.
go back to reference Abdulla J, Nielsen JR (2009) Is the risk of atrial fibrillation higher in athletes than in the general population? A systematic review and meta-analysis. Europace 11:1156–1159CrossRefPubMed Abdulla J, Nielsen JR (2009) Is the risk of atrial fibrillation higher in athletes than in the general population? A systematic review and meta-analysis. Europace 11:1156–1159CrossRefPubMed
2.
go back to reference Aizer A, Gaziano JM, Cook NR, Manson JE, Buring JE, Albert CM (2009) Relation of vigorous exercise to risk of atrial fibrillation. Am J Cardiol 103:1572–1577CrossRefPubMedCentralPubMed Aizer A, Gaziano JM, Cook NR, Manson JE, Buring JE, Albert CM (2009) Relation of vigorous exercise to risk of atrial fibrillation. Am J Cardiol 103:1572–1577CrossRefPubMedCentralPubMed
3.
go back to reference Alessi R, Nusynowitz M, Abildskov JA, Moe GK (1958) Nonuniform distribution of vagal effects on the atrial refractory period. Am J Physiol 194:406–410PubMed Alessi R, Nusynowitz M, Abildskov JA, Moe GK (1958) Nonuniform distribution of vagal effects on the atrial refractory period. Am J Physiol 194:406–410PubMed
5.
go back to reference Bai D (2014) Atrial fibrillation-linked GJA5/connexin40 mutants impaired gap junctions via different mechanisms. FEBS Lett 588:1238–1243CrossRefPubMed Bai D (2014) Atrial fibrillation-linked GJA5/connexin40 mutants impaired gap junctions via different mechanisms. FEBS Lett 588:1238–1243CrossRefPubMed
6.
go back to reference Baldesberger S, Bauersfeld U, Candinas R, Seifert M, Zuber M, Ritter M, Jenni R, Oechslin E, Luthi P, Scharf C, Marti B, Attenhofer Jost CH (2008) Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists. Eur Heart J 29:71–78CrossRefPubMed Baldesberger S, Bauersfeld U, Candinas R, Seifert M, Zuber M, Ritter M, Jenni R, Oechslin E, Luthi P, Scharf C, Marti B, Attenhofer Jost CH (2008) Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists. Eur Heart J 29:71–78CrossRefPubMed
7.
go back to reference Benito B, Gay-Jordi G, Serrano-Mollar A, Guasch E, Shi Y, Tardif JC, Brugada J, Nattel S, Mont L (2011) Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation 123:13–22CrossRefPubMed Benito B, Gay-Jordi G, Serrano-Mollar A, Guasch E, Shi Y, Tardif JC, Brugada J, Nattel S, Mont L (2011) Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation 123:13–22CrossRefPubMed
8.
go back to reference Bramlage P, Cuneo A, Zeymer U, Hochadel M, Richard G, Silber S, Senges J, Nienaber CA, Tebbe U, Kuck KH (2013) Prognosis of patients with atrial fibrillation undergoing percutaneous coronary intervention receiving drug eluting stents. Clin Res Cardiol 102(4):289–297CrossRefPubMed Bramlage P, Cuneo A, Zeymer U, Hochadel M, Richard G, Silber S, Senges J, Nienaber CA, Tebbe U, Kuck KH (2013) Prognosis of patients with atrial fibrillation undergoing percutaneous coronary intervention receiving drug eluting stents. Clin Res Cardiol 102(4):289–297CrossRefPubMed
9.
go back to reference Brugada R, Tapscott T, Czernuszewicz GZ, Marian AJ, Iglesias A, Mont L, Brugada J, Girnona J, Domingo A, Bachinski LL, Roberts R (1997) Identification of a genetic locus for familial atrial fibrillation. N Engl J Med 336:905–911CrossRefPubMed Brugada R, Tapscott T, Czernuszewicz GZ, Marian AJ, Iglesias A, Mont L, Brugada J, Girnona J, Domingo A, Bachinski LL, Roberts R (1997) Identification of a genetic locus for familial atrial fibrillation. N Engl J Med 336:905–911CrossRefPubMed
10.
go back to reference Buiatti A, Hessling G, Semmler V, Ammar S (2014) Remote magnetic navigation for persistent atrial fibrillation ablation via a retrograde aortic access: an approach for patients after atrial septal defect device closure. Clin Res Cardiol 103(12):1028–1030CrossRefPubMed Buiatti A, Hessling G, Semmler V, Ammar S (2014) Remote magnetic navigation for persistent atrial fibrillation ablation via a retrograde aortic access: an approach for patients after atrial septal defect device closure. Clin Res Cardiol 103(12):1028–1030CrossRefPubMed
11.
go back to reference Burstein B, Comtois P, Michael G, Nishida K, Villeneuve L, Yeh JH, Nattel S (2009) Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. Circ Res 105:1213–1222CrossRefPubMed Burstein B, Comtois P, Michael G, Nishida K, Villeneuve L, Yeh JH, Nattel S (2009) Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. Circ Res 105:1213–1222CrossRefPubMed
12.
go back to reference Calvo N, Brugada J, Sitges M, Mont L (2012) Atrial fibrillation and atrial flutter in athletes. Br J Sports Med 46(Suppl 1):i37–i43CrossRefPubMed Calvo N, Brugada J, Sitges M, Mont L (2012) Atrial fibrillation and atrial flutter in athletes. Br J Sports Med 46(Suppl 1):i37–i43CrossRefPubMed
13.
go back to reference Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH, Hindricks G, Kirchhof P, ESC Committee for Practice Guidelines (2012) 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation—developed with the special contribution of the European Heart Rhythm Association. Europace 14:1385–1413CrossRefPubMed Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH, Hindricks G, Kirchhof P, ESC Committee for Practice Guidelines (2012) 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation—developed with the special contribution of the European Heart Rhythm Association. Europace 14:1385–1413CrossRefPubMed
14.
go back to reference Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrabano M, Dobrev D, Wehrens XH (2009) Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest 119:1940–1951PubMedCentralPubMed Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrabano M, Dobrev D, Wehrens XH (2009) Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest 119:1940–1951PubMedCentralPubMed
15.
go back to reference Chun KR, Schmidt B, Kuck KH, Andresen D, Willems S, Spitzer SG, Hoffmann E, Schumacher B, Eckardt L, Seidl K, Jünger C, Horack M, Brachmann J, Senges J (2013) Catheter ablation of atrial fibrillation in the young: insights from the German Ablation Registry. Clin Res Cardiol 102:459–468CrossRefPubMed Chun KR, Schmidt B, Kuck KH, Andresen D, Willems S, Spitzer SG, Hoffmann E, Schumacher B, Eckardt L, Seidl K, Jünger C, Horack M, Brachmann J, Senges J (2013) Catheter ablation of atrial fibrillation in the young: insights from the German Ablation Registry. Clin Res Cardiol 102:459–468CrossRefPubMed
16.
go back to reference Cifelli C, Rose RA, Zhang A, Voigtlaender-Bolz J, Bolz SS, Backx BH, Heximer SP (2008) RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res 103:527–535CrossRefPubMed Cifelli C, Rose RA, Zhang A, Voigtlaender-Bolz J, Bolz SS, Backx BH, Heximer SP (2008) RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res 103:527–535CrossRefPubMed
17.
go back to reference D’Andrea A, Riegler L, Cocchia R, Scarafile R, Salerno G, Gravino R, Golia E, Vriz O, Citro R, Limongelli G, Calabro P, Di Salvo G, Caso P, Russo MG, Bossone E, Calabro R (2010) Left atrial volume index in highly trained athletes. Am Heart J 159:1155–1161CrossRefPubMed D’Andrea A, Riegler L, Cocchia R, Scarafile R, Salerno G, Gravino R, Golia E, Vriz O, Citro R, Limongelli G, Calabro P, Di Salvo G, Caso P, Russo MG, Bossone E, Calabro R (2010) Left atrial volume index in highly trained athletes. Am Heart J 159:1155–1161CrossRefPubMed
18.
go back to reference Delise P, Sitta N, Berton G (2012) Does long-lasting sports practice increase the risk of atrial fibrillation in healthy middle-aged men? Weak suggestions, no objective evidence. J Cardiovasc Med (Hagerstown) 13:381–385CrossRef Delise P, Sitta N, Berton G (2012) Does long-lasting sports practice increase the risk of atrial fibrillation in healthy middle-aged men? Weak suggestions, no objective evidence. J Cardiovasc Med (Hagerstown) 13:381–385CrossRef
19.
go back to reference Dernellis J, Panaretou M (2005) Effect of C-reactive protein reduction on paroxysmal atrial fibrillation. Am Heart J 150:1064CrossRefPubMed Dernellis J, Panaretou M (2005) Effect of C-reactive protein reduction on paroxysmal atrial fibrillation. Am Heart J 150:1064CrossRefPubMed
20.
go back to reference Dobrev D, Carlsson L, Nattel S (2012) Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov 11:275–291CrossRefPubMed Dobrev D, Carlsson L, Nattel S (2012) Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov 11:275–291CrossRefPubMed
21.
go back to reference Drca N, Wolk A, Jensen-Urstad M, Larsson SC (2014) Atrial fibrillation is associated with different levels of physical activity levels at different ages in men. Heart 100(13):1037–1042CrossRefPubMed Drca N, Wolk A, Jensen-Urstad M, Larsson SC (2014) Atrial fibrillation is associated with different levels of physical activity levels at different ages in men. Heart 100(13):1037–1042CrossRefPubMed
22.
go back to reference Drezner JA, Fischbach P, Froelicher V, Marek J, Pelliccia A, Prutkin JM, Schmied CM, Sharma S, Wilson MG, Ackerman MJ, Anderson J, Ashley E, Asplund CA, Baggish AL, Börjesson M, Cannon BC, Corrado D, DiFiori JP, Harmon KG, Heidbuchel H, Owens DS, Paul S, Salerno JC, Stein R, Vetter VL (2013) Normal electrocardiographic findings: recognizing physiological adaptations in athletes. Br J Sports Med 47:125–136CrossRefPubMed Drezner JA, Fischbach P, Froelicher V, Marek J, Pelliccia A, Prutkin JM, Schmied CM, Sharma S, Wilson MG, Ackerman MJ, Anderson J, Ashley E, Asplund CA, Baggish AL, Börjesson M, Cannon BC, Corrado D, DiFiori JP, Harmon KG, Heidbuchel H, Owens DS, Paul S, Salerno JC, Stein R, Vetter VL (2013) Normal electrocardiographic findings: recognizing physiological adaptations in athletes. Br J Sports Med 47:125–136CrossRefPubMed
23.
go back to reference Edwards JD, Wilkins RG (1987) Atrial fibrillation precipitated by acute hypovolaemia. Br Med J (Clin Res Ed) 294:283–284CrossRef Edwards JD, Wilkins RG (1987) Atrial fibrillation precipitated by acute hypovolaemia. Br Med J (Clin Res Ed) 294:283–284CrossRef
24.
go back to reference Elosua R, Arquer R, Mont L, Sambola A, Molina L, Garcia-Moran E, Brugada J, Marrugat J (2006) Sport practice and the risk of lone atrial fibrillation: a case-control study. Int J Cardiol 108:332–337CrossRefPubMed Elosua R, Arquer R, Mont L, Sambola A, Molina L, Garcia-Moran E, Brugada J, Marrugat J (2006) Sport practice and the risk of lone atrial fibrillation: a case-control study. Int J Cardiol 108:332–337CrossRefPubMed
25.
go back to reference Engelmann MD, Svendsen JH (2005) Inflammation in the genesis and perpetuation of atrial fibrillation. Eur Heart J 26:2083–2092CrossRefPubMed Engelmann MD, Svendsen JH (2005) Inflammation in the genesis and perpetuation of atrial fibrillation. Eur Heart J 26:2083–2092CrossRefPubMed
26.
go back to reference Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, Maseri A (1997) Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 96:1180–1184CrossRefPubMed Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, Maseri A (1997) Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 96:1180–1184CrossRefPubMed
27.
go back to reference Furlanello F, Bentivegna S, Cappato R, de Ambroggi L (2003) Arrhythmogenic effects of illicit drugs in athletes. Ital Heart J 4:829–837PubMed Furlanello F, Bentivegna S, Cappato R, de Ambroggi L (2003) Arrhythmogenic effects of illicit drugs in athletes. Ital Heart J 4:829–837PubMed
28.
go back to reference Furlanello F, Serdoz LV, Cappato R, de Ambroggi L (2007) Illicit drugs and cardiac arrhythmias in athletes. Eur J Cardiovasc Prev Rehabil 14:487–494CrossRefPubMed Furlanello F, Serdoz LV, Cappato R, de Ambroggi L (2007) Illicit drugs and cardiac arrhythmias in athletes. Eur J Cardiovasc Prev Rehabil 14:487–494CrossRefPubMed
29.
go back to reference Furlanello F, Lupo P, Pittalis M, Foresti S, Vitali-Serdoz L, Francia P, de Ambroggi G, Ferrero P, Nardi S, Inama G, de Ambroggi L, Cappato R (2008) Radiofrequency catheter ablation of atrial fibrillation in athletes referred for disabling symptoms preventing usual training schedule and sport competition. J Cardiovasc Electrophysiol 19:457–462CrossRefPubMed Furlanello F, Lupo P, Pittalis M, Foresti S, Vitali-Serdoz L, Francia P, de Ambroggi G, Ferrero P, Nardi S, Inama G, de Ambroggi L, Cappato R (2008) Radiofrequency catheter ablation of atrial fibrillation in athletes referred for disabling symptoms preventing usual training schedule and sport competition. J Cardiovasc Electrophysiol 19:457–462CrossRefPubMed
30.
go back to reference Gitt A, Smolka W, Michailov G, Bernhardt A, Pittrow D, Lewalter T (2013) Types and outcomes of cardioversion in patients admitted to hospital for atrial fibrillation: results of the German RHYTHM-AF Study. Clin Res Cardiol 102(10):713–723CrossRefPubMed Gitt A, Smolka W, Michailov G, Bernhardt A, Pittrow D, Lewalter T (2013) Types and outcomes of cardioversion in patients admitted to hospital for atrial fibrillation: results of the German RHYTHM-AF Study. Clin Res Cardiol 102(10):713–723CrossRefPubMed
31.
go back to reference Greif M, von Ziegler F, Wakili R, Tittus J, Becker C, Helbig S, Laubender RP, Schwarz W, D’Anastasi M, Schenzle J, Leber AW, Becker A (2013) Increased pericardial adipose tissue is correlated with atrial fibrillation and left atrial dilation. Clin Res Cardiol 102(8):555–562CrossRefPubMed Greif M, von Ziegler F, Wakili R, Tittus J, Becker C, Helbig S, Laubender RP, Schwarz W, D’Anastasi M, Schenzle J, Leber AW, Becker A (2013) Increased pericardial adipose tissue is correlated with atrial fibrillation and left atrial dilation. Clin Res Cardiol 102(8):555–562CrossRefPubMed
32.
go back to reference Grimsmo J, Grundvold I, Maehlum S et al (2010) High prevalence of atrial fibrillation in long-term endurance cross-country skiers: echocardiographic findings and possible predictors-a 28–30 years follow-up study. Eur J Cardiovasc Prev Rehabil 17:100–105CrossRefPubMed Grimsmo J, Grundvold I, Maehlum S et al (2010) High prevalence of atrial fibrillation in long-term endurance cross-country skiers: echocardiographic findings and possible predictors-a 28–30 years follow-up study. Eur J Cardiovasc Prev Rehabil 17:100–105CrossRefPubMed
33.
go back to reference Grundvold I, Skretteberg PT, Liestol K, Gjesdal K, Erikssen G, Kjeldsen SE, Arnesen H, Erikssen J, Bodegard J (2012) Importance of physical fitness on predictive effect of body mass index and weight gain on incident atrial fibrillation in healthy middle-age men. Am J Cardiol 110:425–432CrossRefPubMed Grundvold I, Skretteberg PT, Liestol K, Gjesdal K, Erikssen G, Kjeldsen SE, Arnesen H, Erikssen J, Bodegard J (2012) Importance of physical fitness on predictive effect of body mass index and weight gain on incident atrial fibrillation in healthy middle-age men. Am J Cardiol 110:425–432CrossRefPubMed
34.
go back to reference Grundvold I, Skretteberg PT, Liestol K, Erikssen G, Kjeldsen SE, Arnesen H, Erikssen J, Bodegard J (2012) Upper normal blood pressures predict incident atrial fibrillation in healthy middle-aged men: a 35-year follow-up study. Hypertension 59:198–204CrossRefPubMed Grundvold I, Skretteberg PT, Liestol K, Erikssen G, Kjeldsen SE, Arnesen H, Erikssen J, Bodegard J (2012) Upper normal blood pressures predict incident atrial fibrillation in healthy middle-aged men: a 35-year follow-up study. Hypertension 59:198–204CrossRefPubMed
35.
go back to reference Guasch E, Benito B, Qi X, Cifelli C, Naud P, Shi Y, Mighiu A, Tardif JC, Tadevosyan A, Chen Y, Gillis MA, Iwasaki YA, Dobrev D, Mont L, Heximer S, Nattel S (2013) Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. J Am Coll Cardiol 62:68–77CrossRefPubMed Guasch E, Benito B, Qi X, Cifelli C, Naud P, Shi Y, Mighiu A, Tardif JC, Tadevosyan A, Chen Y, Gillis MA, Iwasaki YA, Dobrev D, Mont L, Heximer S, Nattel S (2013) Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. J Am Coll Cardiol 62:68–77CrossRefPubMed
36.
go back to reference Haissaguerre M, Jais J, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrique S, Le Mouroux A, Le Metayer P, Clementy J (1998) Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 339:659–666CrossRefPubMed Haissaguerre M, Jais J, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrique S, Le Mouroux A, Le Metayer P, Clementy J (1998) Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 339:659–666CrossRefPubMed
37.
go back to reference Heidbüchel H, Anne W, Willems R, Adriaenssens B, van de Werf F, Ector H (2006) Endurance sports is a risk factor for atrial fibrillation after ablation for atrial flutter. Int J Cardiol 107:67–72CrossRefPubMed Heidbüchel H, Anne W, Willems R, Adriaenssens B, van de Werf F, Ector H (2006) Endurance sports is a risk factor for atrial fibrillation after ablation for atrial flutter. Int J Cardiol 107:67–72CrossRefPubMed
38.
go back to reference Hoff HE, Geddes LA (1955) Cholinergic factor in auricular fibrillation. J Appl Physiol 8:177–192PubMed Hoff HE, Geddes LA (1955) Cholinergic factor in auricular fibrillation. J Appl Physiol 8:177–192PubMed
39.
go back to reference Hoogsteen J, Schep G, Van Hemel NM, van der Wall EE (2004) Paroxysmal atrial fibrillation in male endurance athletes. A 9-year follow up. Europace 6:222–228CrossRefPubMed Hoogsteen J, Schep G, Van Hemel NM, van der Wall EE (2004) Paroxysmal atrial fibrillation in male endurance athletes. A 9-year follow up. Europace 6:222–228CrossRefPubMed
40.
go back to reference Karjalainen J, Kujala UM, Kaprio J, Sarna S, Viitasalo M (1998) Lone atrial fibrillation in vigorously exercising middle aged men: case-control study. BMJ 316:1784–1785CrossRefPubMedCentralPubMed Karjalainen J, Kujala UM, Kaprio J, Sarna S, Viitasalo M (1998) Lone atrial fibrillation in vigorously exercising middle aged men: case-control study. BMJ 316:1784–1785CrossRefPubMedCentralPubMed
41.
go back to reference Khan MN, Jais P, Cummings J, Di Biase L, Sanders P, Martin DO, Kautzner J, Hao S, Themistoclakis S, Fanelli R, Potenza D, Massaro R, Wazni O, Schweikert R, Saliba W, Wang P, Al-Ahmad A, Beheiry S, Santarelli P, Starling RC, Dello Russo A, Pelargonio G, Brachmann J, Schibgilla V, Bonso A, Casella M, Raviele A, Haissaguerre M, Natale A, PABA-CHF Investigators (2008) Pulmonary-vein isolation for atrial fibrillation in patients with heart failure. N Engl J Med 359:1778–1785CrossRefPubMed Khan MN, Jais P, Cummings J, Di Biase L, Sanders P, Martin DO, Kautzner J, Hao S, Themistoclakis S, Fanelli R, Potenza D, Massaro R, Wazni O, Schweikert R, Saliba W, Wang P, Al-Ahmad A, Beheiry S, Santarelli P, Starling RC, Dello Russo A, Pelargonio G, Brachmann J, Schibgilla V, Bonso A, Casella M, Raviele A, Haissaguerre M, Natale A, PABA-CHF Investigators (2008) Pulmonary-vein isolation for atrial fibrillation in patients with heart failure. N Engl J Med 359:1778–1785CrossRefPubMed
42.
go back to reference Kochhäuser S, Lohmann HH, Ritter MA, Leitz P, Güner F, Zellerhoff S, Korsukewitz C, Dechering DG, Banken J, Peters NM, Eckardt L, Mönnig G (2014) Neuropsychological impact of cerebral microemboli in ablation of atrial fibrillation. Clin Res Cardiol. doi:10.1007/s00392-014-0777-0 Kochhäuser S, Lohmann HH, Ritter MA, Leitz P, Güner F, Zellerhoff S, Korsukewitz C, Dechering DG, Banken J, Peters NM, Eckardt L, Mönnig G (2014) Neuropsychological impact of cerebral microemboli in ablation of atrial fibrillation. Clin Res Cardiol. doi:10.​1007/​s00392-014-0777-0
43.
go back to reference Lampert R (2012) Evaluation and management of arrhythmia in the athletic patient. Prog Cardiovasc Dis 54:423–431CrossRefPubMed Lampert R (2012) Evaluation and management of arrhythmia in the athletic patient. Prog Cardiovasc Dis 54:423–431CrossRefPubMed
44.
go back to reference Lau DH, Stiles MK, John B, Shashidhar, Young GD, Sanders P (2007) Atrial fibrillation and anabolic steroid abuse. Int J Cardiol 117:e86–e87CrossRefPubMed Lau DH, Stiles MK, John B, Shashidhar, Young GD, Sanders P (2007) Atrial fibrillation and anabolic steroid abuse. Int J Cardiol 117:e86–e87CrossRefPubMed
45.
go back to reference Leong-Sit P, Zado E, Callans DJ, Garcia F, Lin D, Dixit S, Bala R, Riley MP, Hutchinson MD, Cooper J, Gerstenfeld EP, Marchlinski FE (2010) Efficacy and risk of atrial fibrillation ablation before 45 years of age. Circ Arrhythm Electrophysiol 3:452–457CrossRefPubMed Leong-Sit P, Zado E, Callans DJ, Garcia F, Lin D, Dixit S, Bala R, Riley MP, Hutchinson MD, Cooper J, Gerstenfeld EP, Marchlinski FE (2010) Efficacy and risk of atrial fibrillation ablation before 45 years of age. Circ Arrhythm Electrophysiol 3:452–457CrossRefPubMed
47.
48.
go back to reference Linz D, van Hunnik A, Ukena C, Ewen S, Mahfoud F, Schirmer SH, Lenski M, Neuberger HR, Schotten U, Böhm M (2014) Renal denervation: effects on atrial electrophysiology and arrhythmias. Clin Res Cardiol 103(10):765–774CrossRefPubMed Linz D, van Hunnik A, Ukena C, Ewen S, Mahfoud F, Schirmer SH, Lenski M, Neuberger HR, Schotten U, Böhm M (2014) Renal denervation: effects on atrial electrophysiology and arrhythmias. Clin Res Cardiol 103(10):765–774CrossRefPubMed
49.
go back to reference Liu L, Nattel S (1997) Differing sympathetic and vagal effects on atrial fibrillation in dogs: role of refractoriness heterogeneity. Am J Physiol 273:H805–H816PubMed Liu L, Nattel S (1997) Differing sympathetic and vagal effects on atrial fibrillation in dogs: role of refractoriness heterogeneity. Am J Physiol 273:H805–H816PubMed
50.
go back to reference Liu W, Deng J, Wang G, Zhang C, Luo X, Yan D, Su Q, Liu J (2014) KCNE2 modulates cardiac L-type Ca2+ channel. J Mol Cell Cardiol 72:208–218CrossRefPubMed Liu W, Deng J, Wang G, Zhang C, Luo X, Yan D, Su Q, Liu J (2014) KCNE2 modulates cardiac L-type Ca2+ channel. J Mol Cell Cardiol 72:208–218CrossRefPubMed
51.
go back to reference Malouf JF, Kanagala R, Al Atawi FO, Rosales AG, Davison DE, Murali NS, Tsang TS, Chandrasekaran K, Ammash NM, Friedmann PA, Somers VK (2005) High sensitivity C-reactive protein: a novel predictor for recurrence of atrial fibrillation after successful cardioversion. J Am Coll Cardiol 46:1284–1287CrossRefPubMed Malouf JF, Kanagala R, Al Atawi FO, Rosales AG, Davison DE, Murali NS, Tsang TS, Chandrasekaran K, Ammash NM, Friedmann PA, Somers VK (2005) High sensitivity C-reactive protein: a novel predictor for recurrence of atrial fibrillation after successful cardioversion. J Am Coll Cardiol 46:1284–1287CrossRefPubMed
52.
go back to reference Mascia G, Perrotta L, Galanti G, Padeletti L (2013) Atrial fibrillation in athletes. Int J Sports Med 34:379–384PubMed Mascia G, Perrotta L, Galanti G, Padeletti L (2013) Atrial fibrillation in athletes. Int J Sports Med 34:379–384PubMed
53.
go back to reference Moe GK, Abildskov JA (1959) Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge. Am Heart J 58:59–70CrossRefPubMed Moe GK, Abildskov JA (1959) Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge. Am Heart J 58:59–70CrossRefPubMed
54.
go back to reference Molina L, Mont L, Marrugat J, Berruezo A, Brugada J, Brugada J, Rebato C, Elosua R (2008) Long-term endurance sport practice increases the incidence of lone atrial fibrillation in men: a follow-up study. Europace 10:618–623CrossRefPubMed Molina L, Mont L, Marrugat J, Berruezo A, Brugada J, Brugada J, Rebato C, Elosua R (2008) Long-term endurance sport practice increases the incidence of lone atrial fibrillation in men: a follow-up study. Europace 10:618–623CrossRefPubMed
55.
go back to reference Mont L, Sambola L, Brugada J, Vacca M, Marrugat J, Elosua R, Pare C, Azqueta M, Sanz G (2002) Long-lasting sport practice and lone atrial fibrillation. Eur Heart J 23:477–482CrossRefPubMed Mont L, Sambola L, Brugada J, Vacca M, Marrugat J, Elosua R, Pare C, Azqueta M, Sanz G (2002) Long-lasting sport practice and lone atrial fibrillation. Eur Heart J 23:477–482CrossRefPubMed
56.
go back to reference Mont L, Tamborero D, Elosua R, Molina I, Coll-Vinent B, Sitges M, Vidal B, Scalise A, Tejeira A, Berruezo A, Brugada J, GIRAFA Investigators (2008) Physical activity, height, and left atrial size are independent risk factors for lone atrial fibrillation in middle-aged healthy individuals. Europace 10:15–20CrossRefPubMed Mont L, Tamborero D, Elosua R, Molina I, Coll-Vinent B, Sitges M, Vidal B, Scalise A, Tejeira A, Berruezo A, Brugada J, GIRAFA Investigators (2008) Physical activity, height, and left atrial size are independent risk factors for lone atrial fibrillation in middle-aged healthy individuals. Europace 10:15–20CrossRefPubMed
57.
58.
go back to reference Mozaffarian D, Furberg CD, Psaty BM, Siscovick D (2008) Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study. Circulation 118:800–807CrossRefPubMedCentralPubMed Mozaffarian D, Furberg CD, Psaty BM, Siscovick D (2008) Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study. Circulation 118:800–807CrossRefPubMedCentralPubMed
59.
go back to reference Parvez B, Darbar D (2010) Lone AF—etiologic factors and genetic insights into pathophysiolgy. J Atr Fibrillation 1:675–684PubMedCentralPubMed Parvez B, Darbar D (2010) Lone AF—etiologic factors and genetic insights into pathophysiolgy. J Atr Fibrillation 1:675–684PubMedCentralPubMed
60.
go back to reference Pelliccia A, Maron BJ, Di Paolo FM, Biffi A, Quattrini FM, Pisicchio C, Roselli A, Caselli S, Culasso F (2005) Prevalence and clinical significance of left atrial remodeling in competitive athletes. J Am Coll Cardiol 46:690–696CrossRefPubMed Pelliccia A, Maron BJ, Di Paolo FM, Biffi A, Quattrini FM, Pisicchio C, Roselli A, Caselli S, Culasso F (2005) Prevalence and clinical significance of left atrial remodeling in competitive athletes. J Am Coll Cardiol 46:690–696CrossRefPubMed
61.
go back to reference Potpara TS, Lip GY (2011) Lone atrial fibrillation: what is known and what is to come. Int J Clin Pract 65:446–457CrossRefPubMed Potpara TS, Lip GY (2011) Lone atrial fibrillation: what is known and what is to come. Int J Clin Pract 65:446–457CrossRefPubMed
62.
go back to reference Providencia R, Barra S, Paiva L (2013) Atrial fibrillation, elevated troponin, ischemic stroke and adverse outcomes: understanding the connection. Clin Res Cardiol 102(10):701–711CrossRefPubMed Providencia R, Barra S, Paiva L (2013) Atrial fibrillation, elevated troponin, ischemic stroke and adverse outcomes: understanding the connection. Clin Res Cardiol 102(10):701–711CrossRefPubMed
63.
go back to reference Prystowsky EN, Naccarelli GV, Jackman WM, Rinkenberger RL, Heger JJ, Zipes DP (1983) Enhanced parasympathetic tone shortens atrial refractoriness in man. Am J Cardiol 51:96–100CrossRefPubMed Prystowsky EN, Naccarelli GV, Jackman WM, Rinkenberger RL, Heger JJ, Zipes DP (1983) Enhanced parasympathetic tone shortens atrial refractoriness in man. Am J Cardiol 51:96–100CrossRefPubMed
64.
go back to reference Ravelli F, Allessie M (1997) Effects of atrial dilatation on refractory period and vulnerability to atrial fibrillation in the isolated Langendorff-perfused rabbit heart. Circulation 96:1686–1695CrossRefPubMed Ravelli F, Allessie M (1997) Effects of atrial dilatation on refractory period and vulnerability to atrial fibrillation in the isolated Langendorff-perfused rabbit heart. Circulation 96:1686–1695CrossRefPubMed
65.
go back to reference Richter B, Gwechtenberger M, Socas A, Zorn G, Albinni S, Marx M, Bergler-Klein J, Binder T, Wojta J, Gössinger HD (2012) Markers of oxidative stress after ablation of atrial fibrillation are associated with inflammation, delivered radiofrequency energy and early recurrence of atrial fibrillation. Clin Res Cardiol 101(3):217–225CrossRefPubMed Richter B, Gwechtenberger M, Socas A, Zorn G, Albinni S, Marx M, Bergler-Klein J, Binder T, Wojta J, Gössinger HD (2012) Markers of oxidative stress after ablation of atrial fibrillation are associated with inflammation, delivered radiofrequency energy and early recurrence of atrial fibrillation. Clin Res Cardiol 101(3):217–225CrossRefPubMed
66.
go back to reference Rillig A, Schmidt B, Feige B, Wissner E, Metzner A, Arya A, Mathew S, Makimoto H, Wohlmuth P, Ouyang F, Kuck KH, Tilz RR (2013) Left atrial isthmus line ablation using a remote robotic navigation system: feasibility, efficacy and long-term outcome. Clin Res Cardiol 102(12):885–893CrossRefPubMed Rillig A, Schmidt B, Feige B, Wissner E, Metzner A, Arya A, Mathew S, Makimoto H, Wohlmuth P, Ouyang F, Kuck KH, Tilz RR (2013) Left atrial isthmus line ablation using a remote robotic navigation system: feasibility, efficacy and long-term outcome. Clin Res Cardiol 102(12):885–893CrossRefPubMed
67.
go back to reference Sabouret P, Depret-Bixio L, Cotte FE, Marie P, Bedira N, Blin P (2014) Sex differences in stroke prevention in atrial fibrillation in French primary care. Results of the AFIGP (Atrial Fibrillation in General Practice) Database. Clin Res Cardiol 103(11):887–893CrossRefPubMed Sabouret P, Depret-Bixio L, Cotte FE, Marie P, Bedira N, Blin P (2014) Sex differences in stroke prevention in atrial fibrillation in French primary care. Results of the AFIGP (Atrial Fibrillation in General Practice) Database. Clin Res Cardiol 103(11):887–893CrossRefPubMed
68.
go back to reference Schroeter MR, Danner BC, Hünlich M, Schillinger W (2014) Uncommon delayed and late complications after percutaneous left atrial appendage closure with Amplatzer Cardiac Plug. Clin Res Cardiol 103(4):285–290CrossRefPubMed Schroeter MR, Danner BC, Hünlich M, Schillinger W (2014) Uncommon delayed and late complications after percutaneous left atrial appendage closure with Amplatzer Cardiac Plug. Clin Res Cardiol 103(4):285–290CrossRefPubMed
69.
go back to reference Sharifov OF, Fedorov VV, Beloshapko GG, Glukhov AV, Yushmanova AV, Rosenshtraukh LV (2004) Roles of adrenergic and cholinergic stimulation in spontaneous atrial fibrillation in dogs. J Am Coll Cardiol 43:483–490CrossRefPubMed Sharifov OF, Fedorov VV, Beloshapko GG, Glukhov AV, Yushmanova AV, Rosenshtraukh LV (2004) Roles of adrenergic and cholinergic stimulation in spontaneous atrial fibrillation in dogs. J Am Coll Cardiol 43:483–490CrossRefPubMed
70.
go back to reference Sorokin AV, Araujo CG, Zweibel S, Thompson PD (2011) Atrial fibrillation in endurance-trained athletes. Br J Sports Med 45:185–188CrossRefPubMed Sorokin AV, Araujo CG, Zweibel S, Thompson PD (2011) Atrial fibrillation in endurance-trained athletes. Br J Sports Med 45:185–188CrossRefPubMed
71.
go back to reference Sullivan ML, Martinez CM, Gallagher EJ (1999) Atrial fibrillation and anabolic steroids. J Emerg Med 17:851–857CrossRefPubMed Sullivan ML, Martinez CM, Gallagher EJ (1999) Atrial fibrillation and anabolic steroids. J Emerg Med 17:851–857CrossRefPubMed
72.
go back to reference Sun Y, Tong X, Chen H, Huang T, Shao Q, Huang W, Laird DW, Bai D (2014) An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels. Dis Model Mech 7:561–569CrossRefPubMedCentralPubMed Sun Y, Tong X, Chen H, Huang T, Shao Q, Huang W, Laird DW, Bai D (2014) An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels. Dis Model Mech 7:561–569CrossRefPubMedCentralPubMed
73.
go back to reference Swanson DR (2008) Running, esophageal acid reflux, and atrial fibrillation: a chain of events linked by evidence from separate medical literatures. Med Hypotheses 71:178–185CrossRefPubMedCentralPubMed Swanson DR (2008) Running, esophageal acid reflux, and atrial fibrillation: a chain of events linked by evidence from separate medical literatures. Med Hypotheses 71:178–185CrossRefPubMedCentralPubMed
74.
go back to reference Tang RB, Yan XL, Dong JZ, Kalifa J, Long DY, Yu RH, Bai R, Kang JP, Wu JH, Sang CH, Ning M, Jiang CX, Salim M, Ma CS (2014) Predictors of recurrence after a repeat ablation procedure for paroxysmal atrial fibrillation: role of left atrial enlargement. Europace. doi:10.1093/europace/euu013 [published Online First: 1 April 2014] Tang RB, Yan XL, Dong JZ, Kalifa J, Long DY, Yu RH, Bai R, Kang JP, Wu JH, Sang CH, Ning M, Jiang CX, Salim M, Ma CS (2014) Predictors of recurrence after a repeat ablation procedure for paroxysmal atrial fibrillation: role of left atrial enlargement. Europace. doi:10.​1093/​europace/​euu013 [published Online First: 1 April 2014]
75.
go back to reference Thelle DS, Selmer R, Gjesdal K, Sakshaug S, Jugessur A, Graff-Iversen S, Tverdal A, Nystad W (2013) Resting heart rate and physical activity as risk factors for lone atrial fibrillation: a prospective study of 309,540 men and women. Heart 99:1755–1760CrossRefPubMed Thelle DS, Selmer R, Gjesdal K, Sakshaug S, Jugessur A, Graff-Iversen S, Tverdal A, Nystad W (2013) Resting heart rate and physical activity as risk factors for lone atrial fibrillation: a prospective study of 309,540 men and women. Heart 99:1755–1760CrossRefPubMed
76.
go back to reference Turagam MK, Velagapudi P, Kocheril AG (2012) Atrial fibrillation in athletes. Am J Cardiol 109:296–302CrossRefPubMed Turagam MK, Velagapudi P, Kocheril AG (2012) Atrial fibrillation in athletes. Am J Cardiol 109:296–302CrossRefPubMed
77.
go back to reference Verheule S, Sato T, Everett T, Engle SK, Otten D, der Rubart-von Lohe M, Nakajima HO, Nakajima H, Field LJ, Olgin JE (2004) Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1. Circ Res 94:1458–1465CrossRefPubMedCentralPubMed Verheule S, Sato T, Everett T, Engle SK, Otten D, der Rubart-von Lohe M, Nakajima HO, Nakajima H, Field LJ, Olgin JE (2004) Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1. Circ Res 94:1458–1465CrossRefPubMedCentralPubMed
78.
go back to reference Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D (2012) Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+–Ca2+ exchanger function underlie delayed after depolarizations in patients with chronic atrial fibrillation. Circulation 125:2059–2070CrossRefPubMed Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D (2012) Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+–Ca2+ exchanger function underlie delayed after depolarizations in patients with chronic atrial fibrillation. Circulation 125:2059–2070CrossRefPubMed
79.
go back to reference Wakili R, Clauss S, Schmidt V, Ulbricht M, Hahnefeld A, Schüssler F, Siebermair J, Kääb S, Estner HL (2014) Impact of real-time contact force and impedance measurement in pulmonary vein isolation procedures for treatment of atrial fibrillation. Clin Res Cardiol 103(2):97–106CrossRefPubMed Wakili R, Clauss S, Schmidt V, Ulbricht M, Hahnefeld A, Schüssler F, Siebermair J, Kääb S, Estner HL (2014) Impact of real-time contact force and impedance measurement in pulmonary vein isolation procedures for treatment of atrial fibrillation. Clin Res Cardiol 103(2):97–106CrossRefPubMed
80.
go back to reference Wang TJ, Parise H, Levy D, D’Agostino RB Sr, Wolf PA, Vasan RS, Benjamin EJ (2004) Obesity and the risk of new-onset atrial fibrillation. JAMA 292:2471–2477CrossRefPubMed Wang TJ, Parise H, Levy D, D’Agostino RB Sr, Wolf PA, Vasan RS, Benjamin EJ (2004) Obesity and the risk of new-onset atrial fibrillation. JAMA 292:2471–2477CrossRefPubMed
81.
go back to reference Wang J, Yang YM, Zhu J, Zhang H, Shao XH, Tian L, Huang B, Yu LT, Gao X, Wang M (2014) Overweight is associated with improved survival and outcomes in patients with atrial fibrillation. Clin Res Cardiol 103(7):533–542CrossRefPubMed Wang J, Yang YM, Zhu J, Zhang H, Shao XH, Tian L, Huang B, Yu LT, Gao X, Wang M (2014) Overweight is associated with improved survival and outcomes in patients with atrial fibrillation. Clin Res Cardiol 103(7):533–542CrossRefPubMed
82.
go back to reference Wolf PA, Benjamin EJ, Belanger AJ, Kannel WB, Levy D, D’Agostino RB (1996) Secular trends in the prevalence of atrial fibrillation: The Framingham Study. Am Heart J 131:790–795CrossRefPubMed Wolf PA, Benjamin EJ, Belanger AJ, Kannel WB, Levy D, D’Agostino RB (1996) Secular trends in the prevalence of atrial fibrillation: The Framingham Study. Am Heart J 131:790–795CrossRefPubMed
83.
go back to reference Yalcin MU, Gurses KM, Kocyigit D, Kesikli SA, Ates AH, Evranos B, Yorgun H, Sahiner ML, Kaya EB, Oto MA, Guc D, Ozer N, Aytemir K (2014) Elevated M2-muscarinic and beta-1 adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation. Clin Res Cardiol. doi:10.1007/s00392-014-0776-1 Yalcin MU, Gurses KM, Kocyigit D, Kesikli SA, Ates AH, Evranos B, Yorgun H, Sahiner ML, Kaya EB, Oto MA, Guc D, Ozer N, Aytemir K (2014) Elevated M2-muscarinic and beta-1 adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation. Clin Res Cardiol. doi:10.​1007/​s00392-014-0776-1
84.
go back to reference Yue L, Xie J, Nattel S (2011) Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res 89:744–753CrossRefPubMedCentralPubMed Yue L, Xie J, Nattel S (2011) Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res 89:744–753CrossRefPubMedCentralPubMed
85.
go back to reference Zhang XD, Gu J, Jiang WF, Zhao L, Wang YL, Liu YG, Zhou L, Gu JN, Wu SH, Xu K, Liu X (2013) The impact of age on the efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation. Int J Cardiol 168:2693–2698CrossRefPubMed Zhang XD, Gu J, Jiang WF, Zhao L, Wang YL, Liu YG, Zhou L, Gu JN, Wu SH, Xu K, Liu X (2013) The impact of age on the efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation. Int J Cardiol 168:2693–2698CrossRefPubMed
86.
go back to reference Zhang M, Tao H, Shi KH (2014) Renal denervation as a friend of catheter ablation in patients with atrial fibrillation and hypertension. Clin Res Cardiol. doi:10.1007/s00392-014-0752-9 Zhang M, Tao H, Shi KH (2014) Renal denervation as a friend of catheter ablation in patients with atrial fibrillation and hypertension. Clin Res Cardiol. doi:10.​1007/​s00392-014-0752-9
87.
go back to reference Zusman O, Amit G, Gilutz H, Zagher D (2012) The significance of new onset atrial fibrillation complicating acute myocardial infarction. Clin Res Cardiol 101(1):17–22CrossRefPubMed Zusman O, Amit G, Gilutz H, Zagher D (2012) The significance of new onset atrial fibrillation complicating acute myocardial infarction. Clin Res Cardiol 101(1):17–22CrossRefPubMed
Metadata
Title
Atrial fibrillation and long-term sports practice: epidemiology and mechanisms
Authors
S. Wernhart
M. Halle
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical Research in Cardiology / Issue 5/2015
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-014-0805-0

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