Top

Clinical Research in Cardiology

Published in:

01-07-2009 | Clinical Correspondence

Iatrogenic epinephrine-induced reverse Takotsubo cardiomyopathy: direct evidence supporting the role of catecholamines in the pathophysiology of the “broken heart syndrome”

Authors: Ivan V. Litvinov, Mark A. Kotowycz, Sven Wassmann

Published in: Clinical Research in Cardiology | Issue 7/2009

Excerpt

Sirs …

Available only for authorised users

Kurowski V, Kaiser A, von Hof K, Killermann DP, Mayer B, Hartmann F et al (2007) Apical and midventricular transient left ventricular dysfunction syndrome (Tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis. Chest 132:809–816CrossRefPubMed

Dote K, Sato H, Tateishi H, Uchida T, Ishihara M (1991) Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases. J Cardiol 21:203–214PubMed

Bybee KA, Kara T, Prasad A, Lerman A, Barsness GW, Wright RS et al (2004) Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med 141:858–865PubMed

Sealove BA, Tiyyagura S, Fuster V (2008) Takotsubo cardiomyopathy. J Gen Intern Med 23:1904–1908CrossRefPubMed

Fripp RR, Lee JC, Downing SE (1981) Inotropic responsiveness of the heart in catecholamine cardiomyopathy. Am Heart J 101:17–21CrossRefPubMed

Kinugawa S, Post H, Kaminski PM, Zhang X, Xu X, Huang H et al (2003) Coronary microvascular endothelial stunning after acute pressure overload in the conscious dog is caused by oxidant processes: the role of angiotensin II type 1 receptor and NAD(P)H oxidase. Circulation 108:2934–2940CrossRefPubMed

Mann DL, Kent RL, Parsons B, Cooper G (1992) Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 85:790–804PubMed

Muders F, Friedrich E, Luchner A, Pfeifer M, Ickenstein G, Hamelbeck B et al (1999) Hemodynamic changes and neurohumoral regulation during development of congestive heart failure in a model of epinephrine-induced cardiomyopathy in conscious rabbits. J Card Fail 5:109–116CrossRefPubMed

Powers FM, Pifarre R, Thomas JX Jr (1994) Ventricular dysfunction in norepinephrine-induced cardiomyopathy. Circ Shock 43:122–129PubMed

10.

Ueyama T (2004) Emotional stress-induced Tako-tsubo cardiomyopathy: animal model and molecular mechanism. Ann N Y Acad Sci 1018:437–444CrossRefPubMed

11.

Ueyama T, Hano T, Kasamatsu K, Yamamoto K, Tsuruo Y, Nishio I (2003) Estrogen attenuates the emotional stress-induced cardiac responses in the animal model of Tako-tsubo (Ampulla) cardiomyopathy. J Cardiovasc Pharmacol 42(Suppl 1):S117–S119PubMed

12.

Ueyama T, Senba E, Kasamatsu K, Hano T, Yamamoto K, Nishio I et al (2003) Molecular mechanism of emotional stress-induced and catecholamine-induced heart attack. J Cardiovasc Pharmacol 41(Suppl 1):S115–S118PubMed

13.

Movahed A, Reeves WC, Mehta PM, Gilliland MG, Mozingo SL, Jolly SR (1994) Norepinephrine-induced left ventricular dysfunction in anesthetized and conscious, sedated dogs. Int J Cardiol 45:23–33CrossRefPubMed

14.

Lee JC, Downing SE (1982) Ventricular function in norepinephrine-induced cardiomyopathic rabbits. Am J Physiol 242:H191–H196PubMed

15.

Lee JC, Downing SE (1976) Effects of insulin on cardiac muscle contraction and responsiveness to norepinephrine. Am J Physiol 230:1360–1365PubMed

16.

Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE (2008) Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med 5:22–29CrossRefPubMed

17.

Senba E, Ueyama T (1997) Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat. Neurosci Res 29:183–207CrossRefPubMed

18.

Snoeckx LH, Cornelussen RN, Van Nieuwenhoven FA, Reneman RS, Van Der Vusse GJ (2001) Heat shock proteins and cardiovascular pathophysiology. Physiol Rev 81:1461–1497PubMed

19.

Ito K, Sugihara H, Kawasaki T, Yuba T, Doue T, Tanabe T et al (2001) Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and 99mTc-tetrofosmin myocardial single photon emission computed tomography. Ann Nucl Med 15:351–355CrossRefPubMed

20.

Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG et al (2004) Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am J Cardiol 94:343–346CrossRefPubMed

21.

Chu SH, Goldspink P, Kowalski J, Beck J, Schwertz DW (2006) Effect of estrogen on calcium-handling proteins, beta-adrenergic receptors, and function in rat heart. Life Sci 79:1257–1267CrossRefPubMed

22.

Kam KW, Qi JS, Chen M, Wong TM (2004) Estrogen reduces cardiac injury and expression of beta1-adrenoceptor upon ischemic insult in the rat heart. J Pharmacol Exp Ther 309:8–15CrossRefPubMed

23.

Derian W, Soundarraj D, Rosenberg MJ (2007) Stress-induced cardiomyopathy: not always apical ballooning. Rev Cardiovasc Med 8:228–233PubMed

24.

Ennezat PV, Pesenti-Rossi D, Aubert JM, Rachenne V, Bauchart JJ, Auffray JL et al (2005) Transient left ventricular basal dysfunction without coronary stenosis in acute cerebral disorders: a novel heart syndrome (inverted Takotsubo). Echocardiography 22:599–602CrossRefPubMed

25.

Lee YP, Poh KK, Lee CH, Tan HC, Razak A, Chia BL et al (2009) Diverse clinical spectrum of stress-induced cardiomyopathy. Int J Cardiol 133:272–275CrossRefPubMed

26.

Marechaux S, Goldstein P, Girardie P, Ennezat PV (2009) Contractile pattern of inverted Takotsubo cardiomyopathy: illustration by two-dimensional strain. Eur J Echocardiogr 10:332–333CrossRefPubMed

27.

Riera M, Llompart-Pou JA, Carrillo A, Blanco C (2008) Head Injury and Inverted Takotsubo Cardiomyopathy. J Trauma (Epub ahead of print)

28.

Mori H, Ishikawa S, Kojima S, Hayashi J, Watanabe Y, Hoffman JI et al (1993) Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli. Cardiovasc Res 27:192–198CrossRefPubMed

29.

Park JH, Kang SJ, Song JK, Kim HK, Lim CM, Kang DH et al (2005) Left ventricular apical ballooning due to severe physical stress in patients admitted to the medical ICU. Chest 128:296–302CrossRefPubMed

30.

Collen J, Bimson W, Devine P (2008) A variant of Takotsubo cardiomyopathy: a rare complication in the electrophysiology lab. J Invasive Cardiol 20:E310–E313PubMed

31.

Bonnemeier H, Ortak J, Burgdorf C, Bode F, Schafer U, Hartmann F et al (2007) “The artichoke heart”: the inverse counterpart of left ventricular apical ballooning. Resuscitation 72:342–343CrossRefPubMed

32.

Meaudre E, Barbou F, Sallaberry M, Cantais E, Petit D, Palmier B (2004) Rapid reversal of global left ventricular dysfunction after accidental injection of 0.75 mg epinephrine in a 20-year-old patient. Acta Anaesthesiol Scand 48:914–916CrossRefPubMed

33.

Fyfe AI, Daly PA, Dorian P, Tough J (1991) Reversible “cardiomyopathy” after accidental adrenaline overdose. Am J Cardiol 67:318–319CrossRefPubMed

34.

Budhwani N, Bonaparte KL, Cuyjet AB, Saric M (2004) Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. Rev Cardiovasc Med 5:130–133PubMed

35.

Sato Y, Tanaka M, Nishikawa T (2000) Reversible catecholamine-induced cardiomyopathy by subcutaneous injections of epinephrine solution in an anesthetized patient. Anesthesiology 92:615–619CrossRefPubMed

36.

Stewart MJ, Fraser DM, Boon N (1992) Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler. Br Heart J 68:221–222CrossRefPubMed

37.

Margey R, Diamond P, McCann H, Sugrue D (2009) Dobutamine stress echo-induced apical ballooning (Takotsubo) syndrome. Eur J Echocardiogr 10:395–399CrossRefPubMed

38.

Cherian J, Kothari S, Angelis D, Atef A, Downey B, Kirkpatrick J Jr (2008) Atypical Takotsubo cardiomyopathy: dobutamine-precipitated apical ballooning with left ventricular outflow tract obstruction. Tex Heart Inst J 35:73–75PubMed

Title: Iatrogenic epinephrine-induced reverse Takotsubo cardiomyopathy: direct evidence supporting the role of catecholamines in the pathophysiology of the “broken heart syndrome”
Authors: Ivan V. Litvinov
Mark A. Kotowycz
Sven Wassmann
Publication date: 01-07-2009
Publisher: D. Steinkopff-Verlag
Published in: Clinical Research in Cardiology / Issue 7/2009
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-009-0028-y

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Iatrogenic epinephrine-induced reverse Takotsubo cardiomyopathy: direct evidence supporting the role of catecholamines in the pathophysiology of the “broken heart syndrome”

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 7/2009

On Lauschke J, Maisch B (2009): athlete’s heart or hypertrophic cardiomyopathy?

The cardiac MRI substudy to ongoing telmisartan alone and in combination with ramipril global endpoint trial/telmisartan randomized assessment study in ACE-intolerant subjects with cardiovascular disease: analysis protocol and baseline characteristics

Hotline update of clinical trials and registries presented at the German Cardiac Society Meeting 2009

Percutaneous closure of complex atrial septum defect guided by real-time 3D transesophageal echocardiography

Interventional closure of two fistulas after aortic valve surgery

Predictors of early mortality in patients with active infective native or prosthetic aortic root endocarditis undergoing homograft aortic root replacement

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page