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Pediatric Surgery International

Published in:

01-06-2018 | Original Article

Symptom development in originally asymptomatic CPAM diagnosed prenatally: a systematic review

Authors: Navot Kantor, Carolyn Wayne, Ahmed Nasr

Published in: Pediatric Surgery International | Issue 6/2018

Abstract

Purpose

For the approximately three quarters of patients with a prenatal diagnosis of congenital pulmonary airway malformation (CPAM) who are asymptomatic at birth, the chance of eventually developing symptoms is unknown. We sought to explore the natural history of asymptomatic CPAM.

Methods

We searched EMBASE, MEDLINE, and the first 50 results from Google Scholar. Studies describing the natural history of prenatally diagnosed, initially asymptomatic CPAM were included. For asymptomatic patients initially managed non-surgically, we tabulated the proportion who went on to develop symptoms as well as the median age at symptom development.

Results

We included data from 19 retrospective studies on 353 patients. Of the 128 patients managed expectantly, 31 (24.2%) developed symptoms requiring surgical intervention. The median age at symptom development was 7.5 months (range 15 days–5 years).

Conclusion

The risk for developing respiratory symptoms exists with originally asymptomatic CPAM patients, but the exact risk is difficult to predict. Parents may be given the value of approximately 1 in 4 as an estimate of the proportion of asymptomatic CPAM patients who go on to develop symptoms, which will help them make an informed decision regarding the option of elective surgery.

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Title: Symptom development in originally asymptomatic CPAM diagnosed prenatally: a systematic review
Authors: Navot Kantor
Carolyn Wayne
Ahmed Nasr
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 6/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4264-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Symptom development in originally asymptomatic CPAM diagnosed prenatally: a systematic review

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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