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Child's Nervous System
Published in: Child's Nervous System 3/2021

01-03-2021 | Medulloblastoma | Case Report

A case of medulloblastoma in a patient with fetal ventricular enlargement

Authors: Yi Li, Masahiro Nonaka, Yonehiro Kanemura, Yoshinori Kodama, Masayuki Mano, Akio Asai

Published in: Child's Nervous System | Issue 3/2021

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Abstract

Medulloblastoma is the second-most common malignant tumor in children. Medulloblastoma has been categorized into four distinct molecular subgroups: WNT, sonic hedgehog (SHH), group 3, and group 4. We report on a male child with medulloblastoma, in whom an enlarged ventricle was diagnosed in utero. Magnetic resonance imaging showed cyst formation in the cerebellar hemisphere initially, with tumor growth being indicated later. Tumor resection was performed when the boy was 12 months old. The histological findings showed extensive nodularity. Further genetic analysis revealed the tumor to be SHH type. This is the first description of a medulloblastoma observed from the fetal stage. Our findings in this case indicate that cyst formation may be the pre-neoplastic lesion of SHH-subtype medulloblastomas.
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Metadata
Title
A case of medulloblastoma in a patient with fetal ventricular enlargement
Authors
Yi Li
Masahiro Nonaka
Yonehiro Kanemura
Yoshinori Kodama
Masayuki Mano
Akio Asai
Publication date
01-03-2021
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 3/2021
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-020-04725-0

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